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Screening for Myositis Antibodies in Interstitial Lung Disease

  • A. M. O’MahonyEmail author
  • G. M. Murphy
  • M. T. Henry
Letter to the Editor

To the editor,

We read with interest the recent article from Fidler et al. [1] published online in LUNG (March 2019) and the previous article from De Sadeleer et al. [2] (March 2018) examining the role of myositis antibodies (MA), which characterize idiopathic inflammatory myositis (IIM), in the evaluation of idiopathic interstitial pneumonia (IIP). In IIM, the lung is the most frequent extra-muscular organ involved. [3] Interstitial lung disease (ILD) occurs in 50% of patients and often presents before connective tissue disease (CTD) features are evident, so the identification of autoantibodies can aid diagnosis in otherwise complex cases [3].

Fidler et al. examined 165 patients with idiopathic ILD and excluded patients with known CTD. 26.7% were identified as having myositis-specific antibodies (MSA) or myositis-associated antibodies (MAA). Fourteen patients (8.5%) had a change in diagnosis as a result of screening. The presence of MA was associated with current smoking (p = 0.008)...


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  1. 1.
    Fidler L, Doubelt I, Kandel S, Fisher JH, Mittoo S, Shapera S (2019) Screening for myositis antibodies in idiopathic interstitial lung disease. Lung. Google Scholar
  2. 2.
    De Sadeleer LJ, De Langhe E, Bodart N, Vigneron A, Bossuyt X, Wuyts WA (2018) Prevalence of myositis-specific antibodies in idiopathic interstitial pneumonias. Lung 196:329–333CrossRefGoogle Scholar
  3. 3.
    Morisset J, Johnson C, Rich E, Collard HR, Lee JS (2016) Management of myositis-related interstitial lung disease. Chest 150(5):1118–1128CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. M. O’Mahony
    • 1
    Email author
  • G. M. Murphy
    • 1
  • M. T. Henry
    • 1
  1. 1.Cork University HospitalCorkIreland

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