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The Effects of Aging on Exhaled Nitric Oxide (FeNO) in a North African Population

  • Sonia RouatbiEmail author
  • Ines Ghannouchi
  • Helmi Bensaad



To determine and explain the effect of age on exhaled nitric oxide values in North African healthy subjects aged from 5 to 83 years.


Prospective cross-sectional study.


Volunteer children adults and elderly healthy subjects were included. A medical questionnaire was used to assess several subject characteristics. The levels of exhaled fraction of nitric oxide (FeNO) were measured by Medisoft HypAir FeNO method. Spirometry function test was done after the FeNO measurement. The following parameters were measured: forced vital capacity (FVC, L); 1st second forced expiratory volume (FEV1, L); FEV1/FVC ratio (absolute value); maximal mid expiratory flow (MMEF, L/s); Mid expiratory flow from 25 to 75% (MEF25%, MEF50%, and MEF75%). Statistical analyses were carried out using Statistica software with a significance set at the 0.05 level.


A significant increase in FeNO is noted between groups with respective age ranges of (5, 17) and (17, 25) years with a breakpoint at 1,397,034 years. A significant decrease of FeNO is noted between groups with respective age ranges of (45, 55) and (55, 65) years with a breakpoint at 6,366,052 years. No statistical significant difference was found between females’ and males’ means FeNO data. Finally, SEL, obesity status, and hypertension contribute significantly in the variations of FeNO values.


The development and aging of the lung touched non-respiratory functions and so modified FeNO values in healthy North African subjects.


Lung aging Exhaled nitric oxide North Africa Lung development 



The authors thank Ines Sfaxi, Ashraf Alquodwa, Mohamed Ali Chouchene, and all the subjects who participated in the present study.

Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflicts of interest concerning this article.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Physiology and Functional ExplorationsFarhat HACHED HospitalSousseTunisia
  2. 2.Laboratory of Physiology, Faculty of Medicine of SousseUniversity of SousseSousseTunisia
  3. 3.Heart Failure (LR12SP09) Research LaboratoryFarhat HACHED HospitalSousseTunisia

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