, Volume 197, Issue 1, pp 113–114 | Cite as

Role of Antigen Type in Survival in Chronic Hypersensitivity Pneumonitis

  • Traci N. AdamsEmail author
  • Chad A. Newton
  • Craig S. Glazer

Hypersensitivity pneumonitis (HP) is a group of granulomatous, interstitial, bronchiolar, and alveolar-filling pulmonary diseases caused by repeated exposure and sensitization to a variety of antigens, the most common of which are avian and mold exposure [1]. Prior studies report conflicting results with regard to the effect of antigen type on survival in HP [2, 3, 4]. To evaluate whether history of avian or mold exposure is associated with clinical outcomes, we evaluated a retrospective cohort of patients with a multidisciplinary diagnosis of HP for an association between avian or mold exposure and overall and transplant-free survival. We also evaluated the diagnostic yield of bronchoscopy in these patients in order to assess for lead-time bias as a possible confounder.

We conducted a retrospective cohort study of all patients with a MDD diagnosis of HP at a single center between 2007 and 2017 as previously described [1]. We identified antigen exposure through a detailed history. We...



The study was funded by the Grant Nos. NCATS KL2TR001103 (CAN), UL1TR001105 (CAN, TA), and 5 T32 HL098040-08 (TA).

Compliance with Ethical Standards

Conflict of interest

The authors have no conflicts of interest to report.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineUniversity of Texas Southwestern Medical CenterDallasUSA

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