Role of Antigen Type in Survival in Chronic Hypersensitivity Pneumonitis
Hypersensitivity pneumonitis (HP) is a group of granulomatous, interstitial, bronchiolar, and alveolar-filling pulmonary diseases caused by repeated exposure and sensitization to a variety of antigens, the most common of which are avian and mold exposure . Prior studies report conflicting results with regard to the effect of antigen type on survival in HP [2, 3, 4]. To evaluate whether history of avian or mold exposure is associated with clinical outcomes, we evaluated a retrospective cohort of patients with a multidisciplinary diagnosis of HP for an association between avian or mold exposure and overall and transplant-free survival. We also evaluated the diagnostic yield of bronchoscopy in these patients in order to assess for lead-time bias as a possible confounder.
We conducted a retrospective cohort study of all patients with a MDD diagnosis of HP at a single center between 2007 and 2017 as previously described . We identified antigen exposure through a detailed history. We...
The study was funded by the Grant Nos. NCATS KL2TR001103 (CAN), UL1TR001105 (CAN, TA), and 5 T32 HL098040-08 (TA).
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Conflict of interest
The authors have no conflicts of interest to report.