, Volume 197, Issue 1, pp 9–13 | Cite as

Difference Between Slow and Forced Vital Capacity and Its Relationship with Dynamic Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease

  • Larissa Martinez
  • Diego Rodrigues
  • Leila Donária
  • Karina C. Furlanetto
  • Felipe Vilaça Cavallari Machado
  • Lorena Paltanin Schneider
  • Marcos Ribeiro
  • Nidia A. Hernandes
  • Fabio PittaEmail author


The aim of the study was to investigate the relationship between slow and forced vital capacity (SVC–FVC) difference with dynamic lung hyperinflation (DH) during the 6-min walking test (6MWT) in subjects with chronic obstructive pulmonary disease (COPD). Twenty-four subjects with COPD (12 males; 67 ± 6 years; forced expiratory volume in first second [FEV1] 56 ± 18% predicted) performed lung function tests by spirometry and plethysmography. DH was assessed by serial measurements of inspiratory capacity (IC) performed during the 6MWT and defined as ∆IC ≥ 150 mL or 10%. IC decrease significantly during the 6MWT (ΔCI: − 0.48 ± − 0.40 L; P < 0.0001), and 18 individuals (75%) presented DH. There was significant difference when comparing IC measured at rest with the other serial IC measurements (P < 0.0001). Correlation between the SVC–FVC difference and DH during the 6MWT was r = − 0.38; P = 0.06. The SVC–FVC difference presented only weak correlation with the development of DH during the 6MWT in patients with COPD.


Pulmonary disease Chronic obstructive Respiratory function tests Vital capacity Inspiratory capacity Total lung capacity Exercise 



The study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq, Brazil.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Griten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J (2005) Standardization of spirometry. Eur Respir J 26(2):319–338CrossRefGoogle Scholar
  2. 2.
    Brusasco V, Pellegrino A, Rodarte JR (1997) Vital capacities in acute and chronic airway obstruction: dependence on flow and volum histories. Eur Respir J 10:1316–1320CrossRefGoogle Scholar
  3. 3.
    Constán E, Medina J, Silvestre A, Alvarez I, Olivas R (2005) Difference between the slow vital capacity and forced vital capacity: predictor of hyperinflation in patients with airflow obstruction. Internet J Pulm Med 4(2):1Google Scholar
  4. 4.
    Langer D, Ciavaglia CE, Neder JA, Webb KA, O’Donnell DE (2014) Lung hyperinflation in COPD: mechanisms, clinical implications and treatment. Expert Rev Respir Med 8(6):731–739CrossRefGoogle Scholar
  5. 5.
    Guenette JA, Webb KA, O’Donnell DE (2012) Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD? Eur Resp J 40:322–329CrossRefGoogle Scholar
  6. 6.
    Alfonso M, Bustamante V, Cebollero P, Antón M, Herrero S, Gáldiz JB (2017) Assessement of dyspnea and dynamic hyperinflation in male patientes with chornic obstrucitve pulmonar disease during six minute walking test and a incremental treadmill cardiorespiratory exercise test. Rev Port Pneumol 23(17):266–272Google Scholar
  7. 7.
    Holland AE, Spruit MA, Troosters T, Puhan MA, Pepin V, Saey D, McCormacj MC, Carlin BW, Sciurba FC, Pitta F, Wanger J, MacIntyre N, Kaminsky DA, Culver BH, Revil SM, Hernandes NA, Andrianopoulos V, Camillo CA, Mitchell KE, Lee AL, Hill CJ, Singh SJ (2014) An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J 44(6):1428–1446CrossRefGoogle Scholar
  8. 8.
    Global Strategy for the Diagnosis, Management, and Prevetion of COPD (2017) Global initiative for chronic lung disease (GOLD) 2017. Accessed Mar 2018
  9. 9.
    Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos R, Casaburi R, Crapo R, Enright P, van der Griten CPM, Gustafsson P, Hankinson J, Jensen R, Johnson D, MacIntyre N, McKay R, Miller MR, Navajas D, Pellegrino R, Viegi G, ATS/ERS task force (2005) Standardization of the measurements of lung volumes. Eur Respir J 26:511–522CrossRefGoogle Scholar
  10. 10.
    Pereira CAC, Sato T, Rodrigues SC (2007) New reference values for forced spirometry in white adults in Brazil. J Bras Pneumol 33:397–406CrossRefGoogle Scholar
  11. 11.
    Neder JA, Andreoni S, Castelo-Filho A, Nery LE (1999) Reference values for lung function. I. Static volumes. Braz J Med Biol Res 32:703–717CrossRefGoogle Scholar
  12. 12.
    Britto RR, Probst VS, de Andrade AF, Samora GA, Hernandes NA, Marinho PE, Karsten M, Pitta F, Parreira VF (2013) Reference equations for the six-minute walk distance based on a Brazilian multicenter study. Braz J Phys Ther 17(6):556–563CrossRefGoogle Scholar
  13. 13.
    O’Donnell DE, Revill SM, Webb KA (2001) Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164:770–777CrossRefGoogle Scholar
  14. 14.
    Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) (2002) II Consenso Brasileiro sobre Espirometria. J Pneumol 28(3):S1–S82Google Scholar
  15. 15.
    Wibmer T, Rüdiger S, Kropf-Sanchen C, Stoiber KM, Rottbauer W, Schumann C (2014) Relation of exercise capacity with lung volumes before and after 6-minute walk test in subjects with COPD. Respir Care 59(11):1687–1695CrossRefGoogle Scholar
  16. 16.
    Yuan W, He X, Wang H, Casaburi R (2014) Increased difference between slow and forced vital capacity is associated with reduce exercise tolerance in COPD patients. BCM Pulm Med 14:16CrossRefGoogle Scholar
  17. 17.
    Guennete JA, Webb KA, O’Donnell DE (2012) Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD? Eur Respir J 40:322–329CrossRefGoogle Scholar
  18. 18.
    Trooster T, Vilaro J, Rabinovich R, Casas A, Barbera JA, Roisin-Rodriguez R, Roca J (2002) Physiological responses to the 6-minute walk test in patients with chronic obstructive pulmonary disease. Eur Respir J 20:564–569CrossRefGoogle Scholar
  19. 19.
    O’Donnell DE, Lam M, Webb KA (1998) Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158:1557–1565CrossRefGoogle Scholar
  20. 20.
    van Gestel AJ, Clarenbach CF, Stowhas AC, Teschler S, Russi EW, Teschler H, Kohler M (2012) Prevalence and prediction of exercise-induced oxygen desaturation in patients with chronic obstructive pulmonary disease. Respiration 84:353–359CrossRefGoogle Scholar
  21. 21.
    Gagnon P, Guenette AJ, Langer D, Laviolette L, Mainguy V, Maltais F, Ribeiro F, Saey D (2014) Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. Int J COPD 9:187–201Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Larissa Martinez
    • 1
  • Diego Rodrigues
    • 1
  • Leila Donária
    • 1
  • Karina C. Furlanetto
    • 1
  • Felipe Vilaça Cavallari Machado
    • 1
  • Lorena Paltanin Schneider
    • 1
  • Marcos Ribeiro
    • 1
  • Nidia A. Hernandes
    • 1
  • Fabio Pitta
    • 1
    Email author
  1. 1.Laboratory of Research in Respiratory Physiotherapy (LFIP), Department of PhysiotherapyUniversidade Estadual de Londrina (UEL)LondrinaBrazil

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