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Lung

, Volume 196, Issue 5, pp 609–616 | Cite as

Inflammatory and Fibrinolytic System in Acute Respiratory Distress Syndrome

  • Mahesh Manjunath Gouda
  • Sadiya B. Shaikh
  • Yashodhar Prabhakar Bhandary
ACUTE LUNG INJURY
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Abstract

Acute respiratory distress syndrome (ARDS) is the most advanced form of acute lung injury (ALI). This is characterized by bilateral pulmonary infiltrates and severe hypoxemia. According to Berlin definition of ARDS, this is defined based on the timings, radiographic changes, edema formation, and severity on the PaO2/FiO2 ratio. During ARDS, the loss of integrity of the epithelium causes the septic shock. The degree of epithelial injury is the major prognostic marker of ARDS. In addition to this, inflammatory cell migration, fibro-proliferation, and activation of apoptosis also play an important role in the pathophysiology of ARDS. The alveolar epithelial cell is the prime target during injury where this cell either undergo apoptosis or epithelial–mesenchymal transition (EMT). Injury to the AECs triggers the changes in the DNA fragmentation and activation of certain apoptotic markers such as caspases at the same time some cells undergo biochemical changes and loses its epithelial morphology as well epithelial biomarkers and gain mesenchymal biomarkers and morphology. In both the cases, the fibrinolytic system plays an important role in maintaining the integrity of the disease process efficiently. This review highlights the research evidence of apoptosis and EMT in lung development, injury and its prognosis in ARDS thereby to develop an effective strategy for the treatment of ARDS.

Keywords

Acute lung injury ARDS Apoptosis EMT 
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Notes

Acknowledgements

The authors would like to thank Yenepoya Research Centre/Yenepoya University for providing the online library resources for writing this review article.

Compliance with Ethical Standards

Conflict of interest

Authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. 1.Yenepoya Research CentreYenepoya (Deemed to be University)MangaloreIndia

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