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The novel seizure quality index for the antidepressant outcome prediction in electroconvulsive therapy: association with biomarkers in the cerebrospinal fluid

  • Laura KranasterEmail author
  • Carolin Hoyer
  • Sonani Mindt
  • Michael Neumaier
  • Norbert Müller
  • Peter Zill
  • Markus J. Schwarz
  • Natalie Moll
  • Beat Lutz
  • Laura Bindila
  • Inga Zerr
  • Matthias Schmitz
  • Kaj Blennow
  • Henrik Zetterberg
  • Dieter Haffner
  • Maren Leifheit-Nestler
  • Cagakan Ozbalci
  • Alexander Sartorius
Original Paper

Abstract

For patients with depression treated with electroconvulsive therapy (ECT), the novel seizure quality index (SQI) can predict the risk of non-response (and non-remission)—as early as after the second ECT session—based the extent of several ictal parameters of the seizure. We aim to test several CSF markers on their ability to predict the degree of seizure quality, measured by the SQI to identify possible factors, that could explain some variability of the seizure quality. Baseline CSF levels of metabolites from the kynurenine pathway, markers of neurodegeneration (tau proteins, β-amyloids and neurogranin), elements of the innate immune system, endocannabinoids, sphingolipids, neurotrophic factors (VEGF) and Klotho were measured before ECT in patients with depression (n = 12) to identify possible correlations with the SQI by Pearson's partial correlation. Negative, linear relationships with the SQI for response were observed for CSF levels of T-tau (rpartial = − 0.69, p = 0.019), phosphatidylcholines (rpartial = − 0.52, p = 0.038) and IL-8 (rpartial = − 0.67, p = 0.047). Regarding the SQI for remission, a negative, linear relationship was noted with CSF levels of the endocannabinoid AEA (rpartial = − 0.70, p = 0.024) and CD163 (rpartial = − 0.68, p = 0.029). In sum, CSF Markers for the innate immune system, for neurodegeneration and from lipids were found to be associated with the SQI for response and remission after adjusting for age. Consistently, higher CSF levels of the markers were always associated with lower seizure quality. Based on these results, further research regarding the mechanism of seizure quality in ECT is suggested.

Keywords

Electroconvulsive therapy Depression Outcome Prediction Cerebrospinal fluid 

Notes

Acknowledgements

LK received support by the German Research Foundation (DFG-Grant no. KR 4689/3-1).

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Laura Kranaster
    • 1
    Email author
  • Carolin Hoyer
    • 2
  • Sonani Mindt
    • 3
  • Michael Neumaier
    • 3
  • Norbert Müller
    • 4
    • 5
  • Peter Zill
    • 4
  • Markus J. Schwarz
    • 6
  • Natalie Moll
    • 6
  • Beat Lutz
    • 7
  • Laura Bindila
    • 7
  • Inga Zerr
    • 8
  • Matthias Schmitz
    • 8
  • Kaj Blennow
    • 9
    • 10
  • Henrik Zetterberg
    • 9
    • 10
    • 11
    • 12
  • Dieter Haffner
    • 13
  • Maren Leifheit-Nestler
    • 13
  • Cagakan Ozbalci
    • 14
    • 15
  • Alexander Sartorius
    • 1
  1. 1.Department of Psychiatry and Psychotherapy, Central Institute of Mental HealthMedical Faculty Mannheim/Heidelberg UniversityMannheimGermany
  2. 2.Department of NeurologyUniversity Medical Centre MannheimMannheimGermany
  3. 3.Institute for Clinical Chemistry, University Medical Centre Mannheim, Faculty of Medicine MannheimUniversity of HeidelbergMannheimGermany
  4. 4.Department of Psychiatry and PsychotherapyLudwig Maximilian University MunichMunichGermany
  5. 5.Marion Von Tessin Memory-ZentrumMünchenGermany
  6. 6.Institute of Laboratory MedicineUniversity Hospital LMU MunichMunichGermany
  7. 7.Institute for Physiological ChemistryUniversity Medical Center Mainz of the Johannes Gutenberg UniversityMainzGermany
  8. 8.Department of Neurology, National TSE (Transmissible Spongiform Encephalopathies) Reference CentreUniversity Medical Center Göttingen and the German Center for Neurodegenerative Diseases (DZNE)GöttingenGermany
  9. 9.Department of Psychiatry and Neurochemistry, Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden
  10. 10.Clinical Neurochemistry LaboratorySahlgrenska University HospitalMölndalSweden
  11. 11.Department of Molecular NeuroscienceUCL Institute of NeurologyLondonUK
  12. 12.UK Dementia Research Institute at UCLLondonUK
  13. 13.Department of Pediatric Kidney, Liver and Metabolic DiseasesHannover Medical SchoolHannoverGermany
  14. 14.Randall Centre for Cell and Molecular BiophysicsKing’s College LondonLondonUK
  15. 15.Heidelberg University Biochemistry CenterHeidelbergGermany

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