Laying out the evidence for the persistence of neurogenesis in the adult human hippocampus

  • Golo KronenbergEmail author
  • Friederike Klempin
Letter to the Editor

Dear Editor,

We read with great interest the recent review article by Isabel Maurus et al. [1], which succinctly summarizes the main beneficial effects of aerobic exercise on negative and cognitive symptoms in schizophrenia and the key neurobiological mechanisms that may underpin these effects. The authors rightly highlight, among other mechanisms, the upregulation of brain-derived neurotrophic factor (BDNF) together with structural changes associated with aerobic exercise. Neurogenesis is a key aspect of structural plasticity and a wealth of experimental knowledge has accumulated on the robust neurogenesis-inducing effects of physical activity in rodents. Moreover, decreased cell proliferation in the dentate gyrus was found in schizophrenia, thereby providing strong, but not conclusive, evidence that reduced neurogenesis forms part of the underlying disease process in the brain [2]. We therefore think that, in their review, the authors may have been overly cautious in their...


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Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.College of Life SciencesUniversity of Leicester and Leicestershire Partnership National Health Service TrustLeicesterUK
  2. 2.Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthKlinik und Poliklinik für Psychiatrie und PsychotherapieBerlinGermany
  3. 3.Max Delbrück Center for Molecular Medicine (MDC)BerlinGermany

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