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Clinicopathologic characteristics of paranasal sinus fungus ball: retrospective, multicenter study in Korea

  • Dae Woo Kim
  • Yong Min Kim
  • Jin-Young Min
  • Jeong-Whun Kim
  • Jin-Kook Kim
  • Ji-Hun Mo
  • Jae-Min Shin
  • Kyu-Sup Cho
  • Sang Gyu Kwak
  • Seung-Heon ShinEmail author
Rhinology

Abstract

Purpose

Fungus ball (FB) is the most common type of fungal rhinosinusitis and the prevalence of FB has increased over the past 10 years. The aim of this study was to compare the clinical characteristics of Korean adult patients with FB and chronic rhinosinusitis (CRS) without FB.

Methods

We retrospectively analyzed data on 1362 patients (147 FB and 1215 CRS) who underwent endoscopic sinus surgery at nine Korean medical centers in 2005, 2010, and 2016. We evaluated the prevalence of FB and compared the clinical characteristics of FB and CRS. Medical records, computed tomography (CT) findings, atopic status, concomitant diseases, tissue, and blood eosinophil count were assessed.

Results

The prevalence of FB was significantly higher in 2016 (15.9%) than in the other years (7.8% in 2005 and 7.5% in 2010). The FB patients were more likely to be female, older, have unilateral disease and less likely to have allergy compared to the CRS patients. The most common main complaint related to CRS and FB was nasal obstruction. CT determined that unilateral disease and maxillary sinus dominancy were common in patients with FB. The incidence of concomitant diseases was much higher in FB, with lower tissue and blood eosinophilia.

Conclusion

FB is commonly encountered in older women with the increased prevalence. FB had a different clinical presentation, radiological findings, and prognosis than CRS. Further studies are needed to understand the pathophysiologic mechanisms underlying the development of FB.

Keywords

Fungus ball Chronic rhinosinusitis Retrospective study Multicenter study 

Notes

Author contributions

Conceptualization: all authors. Data curation: all authors. Formal analysis: SGK. Methodology: all authors. Project administration: S-HS. Writing-original draft: DWK, YMK. Review and editing: DWK, YMK, and S-HS.

Compliance with ethical standards

Conflict of interest

No potential conflict of interest relevant to this article was reported.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Otolaryngology-Head and Neck SurgerySeoul Metropolitan Government Seoul National University Boramae Medical CenterSeoulSouth Korea
  2. 2.Department of Otolaryngology-Head and Neck Surgery, School of MedicineChungnam National UniversityDaejeonSouth Korea
  3. 3.Department of Otolaryngology-Head and Neck Surgery, School of MedicineKyung Hee UniversitySeoulSouth Korea
  4. 4.Department of Otolaryngology-Head and Neck Surgery, College of MedicineSeoul National UniversitySeoulSouth Korea
  5. 5.Department of Otolaryngology-Head and Neck Surgery, School of MedicineKonkuk UniversitySeoulSouth Korea
  6. 6.Department of Otolaryngology-Head and Neck Surgery, School of Medicine, College of MedicineDankook UniversityCheonanSouth Korea
  7. 7.Department of Otolaryngology-Head and Neck Surgery, School of MedicineKorea UniversitySeoulSouth Korea
  8. 8.Department of Otolaryngology-Head and Neck Surgery, School of MedicinePusan National UniversityBusanSouth Korea
  9. 9.Department of Medical Statistics, School of MedicineCatholic University of DaeguGyeongsanSouth Korea
  10. 10.Department of Otolaryngology-Head and Neck Surgery, School of MedicineCatholic University of DaeguDaeguSouth Korea
  11. 11.Department of OtorhinolaryngologyDaegu Catholic University Medical CenterDaeguSouth Korea

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