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ERCC1 C8092A polymorphism predicts fair survival outcome in Japanese patients with pharyngo-laryngeal squamous cell carcinoma

  • Hitoshi HirakawaEmail author
  • Taro Ikegami
  • Satoe Azechi
  • Shinya Agena
  • Jin Uezato
  • Hidetoshi Kinjyo
  • Yukashi Yamashita
  • Katsunori Tanaka
  • Shunsuke Kondo
  • Hiroyuki Maeda
  • Mikio Suzuki
  • Akira Gahana
Head and Neck

Abstract

Purpose

To evaluate the prognostic significance of DNA excision repair gene polymorphisms, excision repair cross-complementation group 1 (ERCC1) and X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) polymorphisms were investigated in Japanese patients with head and neck squamous cell carcinoma (HNSCC).

Methods

A total of 225 consecutive patients with HNSCC who underwent surgery or chemoradiotherapy/radiotherapy (CRT/RT) with curative intent as primary treatment from 2006 to 2017 were recruited. ERCC1 C8092A and XRCC1 Arg399Gln polymorphisms in DNA extracted from individual blood samples were determined by the polymerase chain reaction-restriction fragment length polymorphism method. Cumulative survival was estimated by Kaplan–Meier analysis with a log-rank test and Cox proportional hazards model stratified by treatment arm, adjusting for clinical prognostic factors.

Results

Multivariate analysis showed that carriers with the ERCC1 8092 (C/A+A/A) genotype (hazard ratio, 3.56; 95% confidence interval, 1.22–7.39; p = 0.02) had significantly worse survival than those with ERCC1 8092 C/C who received CRT/RT. Conversely, the XRCC1 Arg399Gln polymorphism did not influence survival in patients who received CRT/RT as well as surgery.

Conclusion

The ERCC1 C8092A polymorphism might be an independent predictor of response to CRT and survival outcome in patients with HNSCC. This is the first report to investigate the role of DNA excision repair gene polymorphisms in patients with head and neck cancer in a Japanese population.

Keywords

DNA repair Single nucleotide polymorphism Survival Head and neck cancer Japanese 

Notes

Funding

This work was supported by JSPS KAKENHI Grant Number (JP17K11391) (Grant-in-Aid for Scientific Research C).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Hitoshi Hirakawa
    • 1
    Email author
  • Taro Ikegami
    • 1
  • Satoe Azechi
    • 2
  • Shinya Agena
    • 1
  • Jin Uezato
    • 1
  • Hidetoshi Kinjyo
    • 1
  • Yukashi Yamashita
    • 1
  • Katsunori Tanaka
    • 1
  • Shunsuke Kondo
    • 1
  • Hiroyuki Maeda
    • 1
  • Mikio Suzuki
    • 1
  • Akira Gahana
    • 1
    • 3
  1. 1.Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of MedicineUniversity of the RyukyusOkinawaJapan
  2. 2.School of MedicineTokai UniversityIseharashiJapan
  3. 3.Department of Otorhinolaryngology-Head and Neck SurgeryUniversity of MiyazakiMiyazakiJapan

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