European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 12, pp 3383–3388 | Cite as

The association of allergic rhinitis severity with neutrophil–lymphocyte and platelet–lymphocyte ratio in adults

  • Ayşe Enise Göker
  • Enis EkinciogluEmail author
  • Maide Hacer Alagöz
  • Ruslan Hummatov
  • Melis E. Arkan
  • Ayca Baskadem Yilmazer
  • Arzu Güngör Doğuşlu
  • Yavuz Uyar



To investigate the association of allergic rhinitis (AR) severity with neutrophil–lymphocyte and platelet–lymphocyte ratios in adult patients.


The study design was prospective observational study and the study included 209 AR patients and 243 healthy individuals. The patient group comprised 38.2% males with a mean age of 31.8 years. All patients who were diagnosed with persistent AR were included. The healthy control group comprised 52.7% males with a mean age of 32.3 years. The blood examination results of patients and healthy individuals were compared in terms of neutrophil–lymphocyte and platelet–lymphocyte ratios. The values were further compared within the patient group, according to AR severity.


The neutrophil–lymphocyte ratio was 1.70 ± 0.65 in the healthy group and 2.02 ± 1.24 in the patient group. The platelet–lymphocyte ratio result was 100.85 ± 25.33 in the healthy group and 120.67 ± 40.59 in the patient group. When we compared the neutrophil–lymphocyte and platelet–lymphocyte ratios between the groups, we found statistically significant differences in both ratios (p = 0.003, p = 0.000, respectively). Both the neutrophil–lymphocyte and the platelet–lymphocyte ratios were higher in patients with moderate–severe AR.


Both neutrophil–lymphocyte and platelet–lymphocyte ratios are useful markers for diagnosis of persistent AR. Specialists may benefit from these markers to assess the severity of the disease at the beginning of the diagnostic process.


Allergic rhinitis Neutrophil–lymphocyte ratio Platelet–lymphocyte ratio 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

The study design was prospective observational study and this research was performed with human participants. All patients were signed written informed consent.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydani Training and Research HospitalUniversity of Health ScienceIstanbulTurkey
  2. 2.Department of BiochemistryOkmeydani Training and Research Hospital, University of Health ScienceIstanbulTurkey

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