European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 11, pp 3013–3019 | Cite as

The relationship of high-frequency distortion product otoacoustic emission (DPOAE) values with hematological parameters in tinnitus patients

  • Akif GunesEmail author
  • Elif Karali
  • Ahmet Ural
  • Fatih Ruzgar
  • Tugba Bayatkara



In this study, we aimed to investigate whether there is any positive or negative correlation between high-frequency distortion product otoacoustic emission (DPOAE) values and mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) in tinnitus patients.


The study was performed with 52 volunteers (27 females, 25 males) aged between 35 and 50 years who presented with tinnitus to the otolaryngology outpatient clinic of a tertiary care center. Pure voice audiometric examination, DPOAE measurement, complete blood count values of the study participants were examined.


In both ears, a significant and negative correlation was observed between 4000 and 8000 Hz airway and 4000 Hz bone conduction pathways with NLR rates (p < 0.05). A statistically significant relationship was found between the bone conduction pathway PTA and discrimination values for both ears and NLR s (p < 0.05). A positive correlation was detected between NLRs and DPOAE measurements recorded at 4444 Hz, 5000 Hz, 8000 Hz, 8889 Hz, 10,000 Hz and 11,429 Hz frequencies in the right and 4444 Hz, 5000 Hz, 6154 Hz, 8000 Hz, 10,000 Hz and 11,429 Hz frequencies in the left ears, respectively (p < 0.05).


We concluded that there is a significant correlation between high-frequency pure tone audiometry measurements and high frequency DPOAE measurements and NLR. Further studies are needed to determine the utility of NLR as a marker for the recognition and follow-up of hearing loss in patients with tinnitus.


Tinnitus Auto-acoustic emission DPOAE Neutrophil/lymphocyte ratio 



No financial support was received for this paper.


No financial support was received.

Compliance with ethical standards

Conflict of interest

Akif Gunes declares that he has no conflict of interest. Elif Karali declares that she has no conflict of interest. Ahmet Ural declares that he has no conflict of interest. Fatih Ruzgar declares that he has noconflict of interest. Tugba Bayatkara declares that she has no conflict of interest.

Ethical approval

This study includes human participants and this study has been carried out in accordance with ethical standards and the Helsinki declaration.

Informed consent

Informed consent was obtained from all participants.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology, Medical SchoolBolu Abant Izzet Baysal UniversityBoluTurkey
  2. 2.Department of Audiology, Medical SchoolBolu Abant Izzet Baysal UniversityBoluTurkey

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