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European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 5, pp 1335–1340 | Cite as

Otosclerosis: anatomical distribution of otosclerotic loci analyzed by high-resolution computed tomography

  • Chihiro YagiEmail author
  • Yuka Morita
  • Kuniyuki Takahashi
  • Manabu Ogi
  • Shinsuke Oshima
  • Yutaka Yamamoto
  • Arata Horii
Otology
  • 37 Downloads

Abstract

Purpose

To clarify the anatomical distribution of otosclerotic loci in otosclerosis.

Methods

Ninety-five patients with surgically confirmed uni- or bilateral otosclerosis were enrolled into the study. Hypodense areas observed in the otic capsule by high-resolution computed tomography (HRCT) were defined as otosclerotic loci. The location and number of lesions were examined, and the probability of lesion overlap and correlation with age/hearing parameters (air and bone conduction threshold, air-bone gaps) were tested.

Results

Otosclerotic loci were confirmed by HRCT in 77 out of 115 operated ears. The three commonly affected sites were the anterior part of the oval window (ant-OW), anterior part of the internal auditory canal (ant-IAC), and pericochlear area (PCochA), with lesions detected in 96.1%, 46.8%, and 26.0% of ears, respectively. Only the ant-OW area was affected in 48.1% of the ears; the ant-IAC in 3.9%; and PCochA in none with significant differences (p < 0.01). The ant-OW lesions preferentially overlapped with ant-IAC (44.6%) than PCochA lesions (27.0%) (p < 0.05). Among double sites diseases, triple sites diseases occurred more commonly in the ant-OW + PCochA group (80%) than ant-OW + ant-IAC group (48.5%) (p < 0.05). There was no correlation between a number of lesions and age/hearing parameters.

Conclusions

Based on the probability of lesion overlap, otosclerotic lesions may initiate at ant-OW followed by ant-IAC and later PCochA. Although the number of lesions showed no immediate correlation with hearing level or age, anatomical stage of the disease estimated by the location and the number of otosclerotic loci could be useful in predicting the future hearing status.

Keywords

Otosclerotic lesion Computed tomography Hypodense areas Anatomical distribution 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the IRB of Niigata University Medical and Dental Hospital (#2017-0271). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    McKenna MJ, Merchant SN (2010) Disorders of bone. In: Merchant SN, Nadol JB (eds) Schuknecht’s pathology of the ear. People’s Medical Pub. House-USA Inc., Shelton, pp 716–719Google Scholar
  2. 2.
    Chole RA, McKenna M (2001) Basic science review: pathophysiology of otosclerosis. Otol Neurotol 22:249–257CrossRefGoogle Scholar
  3. 3.
    Wegner I, van Waes AMA, Bittermann AJ et al (2016) A systematic review of the diagnostic value of CT imaging in diagnosing otosclerosis. Otol Neurotol 37:9–15CrossRefGoogle Scholar
  4. 4.
    Yamashita K, Yoshiura T, Hiwatashi A et al (2014) The radiological diagnosis of fenestral otosclerosis: the utility of histogram analysis using multidetector row CT. Eur Arch Otorhinolaryngol 271:3277–3282CrossRefGoogle Scholar
  5. 5.
    Redfors YD, Gröndahl HG, Hellgren J et al (2012) Otosclerosis: anatomy and pathology in the temporal bone assessed by multi-slice and cone-beam CT. Otol Neurotol 33:922–927Google Scholar
  6. 6.
    Marx M, Lagleyre S, Escudé B et al (2011) Correlations between CT scan findings and hearing thresholds in otosclerosis. Acta Otolaryngol 131:351–357CrossRefGoogle Scholar
  7. 7.
    Lagleyre S, Sorrentino T, Calmels MN et al (2009) Reliability of high-resolution CT scan in diagnosis of otosclerosis. Otol Neurotol 30:1152–1159CrossRefGoogle Scholar
  8. 8.
    Lee TC, Aviv RI, Chen JM et al (2009) CT grading of otosclerosis. Am J Neuroradiol 30:1435–1439CrossRefGoogle Scholar
  9. 9.
    Bozorg Grayeli A, Saint Yrieix C, Imauchi Y et al (2004) Temporal bone density measurements using CT in otosclerosis. Acta Otolaryngol 124:1136–1140CrossRefGoogle Scholar
  10. 10.
    Kiyomizu K, Tono T, Yang D et al (2004) Correlation of CT analysis and audiometry in Japanese otosclerosis. Auris Nasus Larynx 31:125–129CrossRefGoogle Scholar
  11. 11.
    Quesnel AM, Moonis G, Appel J et al (2013) Correlation of computed tomography with histopathology in otosclerosis. Otol Neurotol 34:22–28CrossRefGoogle Scholar
  12. 12.
    Shin YJ, Fraysse B, Deguine O et al (2001) Sensorineural hearing loss and otosclerosis: a clinical and radiologic survey of 437 cases. Acta Otolaryngol 121:200–204CrossRefGoogle Scholar
  13. 13.
    Valvassori GE (1993) Imaging of otosclerosis. Otolaryngol Clin N Am 26:359–371Google Scholar
  14. 14.
    Zhu MM, Sha Y, Zhuang PY et al (2010) Relationship between high-resolution computed tomography densitometry and audiometry in otosclerosis. Auris Nasus Larynx 37:669–675CrossRefGoogle Scholar
  15. 15.
    Vicente Ade O, Yamashita HK, Albernaz PL et al (2006) Computed tomography in the diagnosis of otosclerosis. Otolaryngol Head Neck Surg 134:685–692CrossRefGoogle Scholar
  16. 16.
    Benjamin J, Frank B, Anne-Michelle N et al (2010) Computed tomography and otosclerosis: a practical method to correlate the site affected to hearing loss. Ann Otol Rhinol Laryngol 119:789–794CrossRefGoogle Scholar
  17. 17.
    Naumann IC, Porcellini B, Fisch U (2005) Otosclerosis: incidence of positive findings on high-resolution computed tomography and their correlation to audiological test data. Ann Otol Rhinol Laryngol 114:709–716CrossRefGoogle Scholar
  18. 18.
    Hueb MM, Goycoolea MV, Paparella MM (1991) Otosclerosis: the University of Minnesota temporal bone collection. Otolaryngol Head Neck Surg 105:396–405CrossRefGoogle Scholar
  19. 19.
    Schuknecht HF, Barber W (1985) Histologic variants in otosclerosis. Laryngoscope 95:1307–1317CrossRefGoogle Scholar
  20. 20.
    Markou K, Stavrakas M, Karkos P et al (2016) Juvenile otosclerosis: a case presentation and review of the literature. Case Rep 2016:bcr2015214232Google Scholar
  21. 21.
    Gristwood RE, Venables WN (1983) Pregnancy and otosclerosis. Clin Otolaryngol Allied Sci 8:205–210CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Otolaryngology Head and Neck SurgeryNiigata University Graduate School of Medical and Dental SciencesNiigataJapan
  2. 2.Department of OtorhinolaryngologyJikei University School of MedicineTokyoJapan

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