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European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 5, pp 1341–1347 | Cite as

Outcomes of endoscopic sinus surgery in adult lung transplant patients with cystic fibrosis

  • Paolo LuparelloEmail author
  • Maria S. Lazio
  • Luca Voltolini
  • Beatrice Borchi
  • Giovanni Taccetti
  • Giandomenico Maggiore
Rhinology

Abstract

Purpose

Cystic Fibrosis (CF) is the most common autosomal recessive disease in Caucasian population. Due to its pathological mechanism, chronic rhino sinusitis (CRS) associated or not with nasal polyposis usually occurs in adults and affects close to one-half of all CF patients. The goal of our work was to evaluate the impact of Endoscopic Sinus Surgery (ESS) in the quality of life (QoL) of the CF patients and demonstrate an improvement of the functional outcomes in the patients underwent the surgical procedure rather than in the not treated ones, particulary in lung transplant patients.

Methods

We studied 54 adult patients affected by CF. Lund–Kennedy, Lund–Mackay scores, and SNOT-22 were analysed. 14 had lung transplant and 9 had both lung tranplant and ESS procedures.

Results

22 (40.7%) out of 54 CF patients underwent ESS. This group presented more likely complaints consistent with CRS. Lund–Kennedy and Lund–Mackay scores appeared higher in the ESS group: 10 (range of 6–12) and 15 (range of 12–20), respectively. SNOT-22 showed median values for non-ESS and ESS group of 20 (range of 3–68) and 40 (range of 10–73), respectively.

Conclusions

ESS represents the best option to improve clinical QoL of CF patients who do not response to conventional medical therapy, with a stabilization of respiratory function after transplantation.

Keywords

Cystic fibrosis Endoscopic sinus surgery Lung transplant SNOT-22 Quality of life 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Surgery and Translational Medicine, Clinic of Otolaryngology, Head and Neck Surgery, Careggi University HospitalUniversity of FlorenceFlorenceItaly
  2. 2.Department of Thoracic SurgeryUniversity Hospital CareggiFlorenceItaly
  3. 3.Infectious Disease DepartmentCareggi University and HospitalFlorenceItaly
  4. 4.Anna Meyer Children’s University HospitalFlorenceItaly

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