The effectiveness of high-resolution ultrasound in the assessment of the carotid intima–media thickness for postirradiated neck
The carotid intimal–medial thickness (CIMT) is a strong predictor of future cardiovascular events. We assessed the mean CIMT and evaluated associated factors in head and neck cancer (HNC) patients.
Materials and methods
Between January 2016 and March 2018, 70 volunteers underwent automatic ultrasound measurement of the common carotid artery CIMT. A mean CIMT ≥ 1.0 mm was regarded as an elevated risk for cardiovascular disease (CVD). We aimed to investigate the risk factors for an increased mean CIMT.
We recruited 20 HNC survivors and 50 noncancer control individuals. Multiple linear regression analysis showed that old age (β = 0.006, 95% confidence interval, CI 0.004–0.008), increased weight (β = 0.003, 95% CI 0.001–0.005), hypertension (β = 0.10, 95% CI 0.03–0.17), and prior irradiation (β = 0.13, 95% CI 0.08–0.19) were positively correlated with the mean CIMT. From logistic regression analysis, it was shown that patients who underwent radiotherapy (OR 13.5, 95% CI 1.48–122.8) and who had higher bodyweight (OR 1.09, 95% CI 1.01–1.18) had a significantly higher risk of developing CVD.
Measurement of the mean CIMT using ultrasound could be useful for assessing CVD risk in HNC survivors after neck irradiation.
KeywordsCarotid intima–media thickness Head and neck cancer Irradiation Cardiovascular disease
This work was supported by grants from the Far Eastern Memorial Hospital Research Program (FEMH - 2017-C-012).
Compliance with ethical standards
Conflict of interest
All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 4.Liao LJ, Wang CT, Young YH, Cheng PW (2010) Real-time and computerized sonographic scoring system for predicting malignant cervical lymphadenopathy. Head Neck 32(5):594–598Google Scholar
- 8.Matsuda E, Fukuhara T, Donishi R et al (2017) Usefulness of a novel ultrasonographic classification based on anechoic area patterns for differentiating Warthin tumors from pleomorphic adenomas of the parotid gland. Yonago Acta Med 60(4):220–226Google Scholar
- 21.Hopewell JW, Campling D, Calvo W et al (1986) Vascular irradiation damage: its cellular basis and likely consequences. Br J Cancer Suppl 7:181–191Google Scholar
- 24.Pereira Lima MN, Biolo A, Foppa M et al (2011) A prospective, comparative study on the early effects of local and remote radiation therapy on carotid intima–media thickness and vascular cellular adhesion molecule-1 in patients with head and neck and prostate tumors. Radiother Oncol 101(3):449–453CrossRefGoogle Scholar