Correlation between the duration of locoregional control and survival in T1–T2 oropharyngeal cancer patients
- 21 Downloads
To investigate the correlation between the time to locoregional recurrence and survival in T1–T2 oropharyngeal squamous-cell carcinoma (OPSCC) patients.
A retrospective, single-site study of patients with T1–T2 OPSCC treated with curative intent between 2000 and 2015 who had a locoregional recurrence without distant metastases. Patients without a disease-free interval (i.e., persistent macroscopic disease after the end of treatment and a time to locoregional recurrence of less than 3 months) were excluded. The endpoint considered was overall survival (OS).
Out of 602 T1–T2 OPSCC patients, 121 patients had a locoregional recurrence and they were, hence, analyzed. All of the patients were heavy-smokers, with a consumption of more than 20 pack-years. The recurrence was local in 59.5%, regional in 27.3%, and both local and regional in 13.2% of the patients. The median time to locoregional recurrence and median OS was 15 months and 44 months, respectively. The time to locoregional recurrence was correlated with OS (p < 0.0001). In multivariate analyses, factors associated with survival were an initial N0–N2a versus N2b–N3 nodal staging and a 12-month threshold for the time to locoregional recurrence.
Locoregional control in T1–T2 OPSCC is not only a qualitative prognostic factor but also a quantitative prognostic factor of survival. A time to locoregional recurrence of less than 12 months was correlated with an unfavorable prognosis.
KeywordsOropharyngeal neoplasms Locoregional recurrence Disease-free interval Survival
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Formal consent for participation has been given by patients.
- 10.Jayaram SC, Muzaffar SJ, Ahmed I, Dhanda J, Paleri V, Mehanna H (2016) Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: a systematic review and meta-analysis. Head Neck 38(12):1855–1861. https://doi.org/10.1002/hed.24531 CrossRefGoogle Scholar
- 14.Kim J, Kim S, Albergotti WG, Choi PA, Kaplan DJ, Abberbock S, Johnson JT, Gildener-Leapman N (2015) Selection of ideal candidates for surgical salvage of head and neck squamous cell carcinoma: effect of the Charlson-Age Comorbidity Index and oncologic characteristics on 1-year survival and hospital course. JAMA Otolaryngol Head Neck Surg 141(12):1059–1065. https://doi.org/10.1001/jamaoto.2015.2158 CrossRefGoogle Scholar
- 15.Hamoir M, Holvoet E, Ambroise J, Lengele B, Schmitz S (2017) Salvage surgery in recurrent head and neck squamous cell carcinoma: oncologic outcome and predictors of disease-free survival. Oral Oncol 67:1–9. https://doi.org/10.1016/j.oraloncology.2017.01.008 CrossRefGoogle Scholar
- 20.Lacau St Guily J, Rousseau A, Baujat B, Perie S, Schultz P, Barry B, Dufour X, Malard O, Pretet JL, Clavel C, Birembaut P, Franceschi S, Papillophar G (2017) Oropharyngeal cancer prognosis by tumour HPV status in France: the multicentric Papillophar study. Oral Oncol 67:29–36. https://doi.org/10.1016/j.oraloncology.2017.01.012 CrossRefGoogle Scholar
- 21.Huang SH, Xu W, Waldron J, Siu L, Shen X, Tong L, Ringash J, Bayley A, Kim J, Hope A, Cho J, Giuliani M, Hansen A, Irish J, Gilbert R, Gullane P, Perez-Ordonez B, Weinreb I, Liu FF, O’Sullivan B (2015) Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas. J Clin Oncol 33(8):836–845. https://doi.org/10.1200/JCO.2014.58.6412 CrossRefGoogle Scholar
- 23.Hong AM, Martin A, Chatfield M, Jones D, Zhang M, Armstrong B, Lee CS, Harnett G, Milross C, Clark J, Elliott M, Smee R, Corry J, Liu C, Porceddu S, Rees G, Rose B (2013) Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma. Int J Cancer 132(12):2748–2754. https://doi.org/10.1002/ijc.27956 CrossRefGoogle Scholar
- 24.Maxwell JH, Kumar B, Feng FY, Worden FP, Lee JS, Eisbruch A, Wolf GT, Prince ME, Moyer JS, Teknos TN, Chepeha DB, McHugh JB, Urba SG, Stoerker J, Walline HM, Kurnit DM, Cordell KG, Davis SJ, Ward PD, Bradford CR, Carey TE (2010) Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res 16(4):1226–1235. https://doi.org/10.1158/1078-0432.CCR-09-2350 CrossRefGoogle Scholar
- 25.Lin BM, Wang H, D’Souza G, Zhang Z, Fakhry C, Joseph AW, Drake VE, Sanguineti G, Westra WH, Pai SI (2013) Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma. Cancer 119(19):3462–3471. https://doi.org/10.1002/cncr.28250 CrossRefGoogle Scholar