European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 3, pp 665–672 | Cite as

Clinical features and management of Meniere’s disease patients with drop attacks

  • Qianru Wu
  • Xuanyi Li
  • Yan Sha
  • Chunfu DaiEmail author



The aims of the present study are to investigate the variations in clinical features, including medical history, hearing function, vestibular function, and degree of endolymphatic hydrops (EH), in Meniere’s disease (MD) patients with and without drop attacks (DAs), and to examine the efficacy of intratympanic gentamicin (ITG) treatment in alleviating DAs.


In total, 177 unilateral definite MD patients, including 16 patients with DAs and 161 patients without DAs, were enrolled. The results of hearing test, vestibular-evoked myogenic potentials (VEMPs), and magnetic resonance imaging (MRI) were analyzed. Thirteen patients with DAs received a single ITG treatment and were followed up.


The disease course of MD in the DA group was significantly longer than that in the control group (p = 0.007). MD patients with DAs had significantly greater hearing loss and worse EH than MD patients without DAs (p < 0.05). However, there was no between-group difference in vestibular function. In the study, 92.31% of refractory definite MD patients with DAs achieved satisfactory control of DAs after ITG treatment.


MD patients with DAs tend to suffer from severe hearing loss and a significant degree of EH in the inner ear. However, the vestibular function of MD patients with DAs may not be completely abolished, but be sensitive to stimulating signals. ITG treatment, which helps to decrease vestibular sensitivity, was an effective treatment to control DAs.


Tumarkin attack Vertigo Endolymphatic hydrops Otolithic organ 



This work was supported by the National Natural Science Foundation of China (no. 81570917 [C. F. D.]).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the present study involving human participants were approved by the medical ethics committee of the Eye, Ear, Nose & Throat Hospital and in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

All patients included in the study signed the informed consent. For this type of study formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Otology and Skull Base Surgery, Hearing Research Key Lab of Health Ministry of China, Eye and Ear Nose and Throat HospitalFudan UniversityShanghaiChina
  2. 2.Department of OtolaryngologyThe Affiliated Hospital of Xuzhou Medical CollegeXuzhouChina
  3. 3.Department of Radiology, Eye and Ear Nose and Throat HospitalFudan UniversityShanghaiChina

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