Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case–control study using a national sample cohort

  • Hyo Geun Choi
  • Joon Kyu Lee
  • Il Gyu Kong
  • Hyun Lim
  • So Young KimEmail author



The previous studies suggested an association between osteoporosis and sudden sensory neural hearing loss (SSNHL). The aim of the present study was to evaluate the association between osteoporosis and benign paroxysmal positional vertigo (BPPV).

Materials and methods

Data from the Korean National Health Insurance Service-National Sample Cohort of participants who were ≥ 50 years old were collected from 2002 to 2013. A total of 13,484 BPPV participants were matched with respect to age group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia to 53,936 controls. In both the BPPV and control groups, the previous histories of osteoporosis were evaluated. Crude (simple) and adjusted odds ratios (ORs) of osteoporosis for BPPV were analyzed using unconditional logistic regression analyses. Subgroup analyses were conducted according to age, sex, and BPPV frequency.


A total of 18.64% (2514/13,464) of the BPPV group and 12.21% (6589/53,936) of the control group had a history of osteoporosis (P < 0.001). The adjusted OR of osteoporosis for BPPV was 1.29 (95% CI = 1.23–1.35, P < 0.001). In the subgroup analysis according to age and sex, the ≥ 70-year-old men did not demonstrate a high adjusted OR of osteoporosis for BPPV. All other age and sex subgroups demonstrated high adjusted ORs of osteoporosis for BPPV.


Osteoporosis increased the risk of BPPV in the population aged ≥ 50 years. The OR of osteoporosis was higher in the frequent BPPV group than in the less frequent BPPV group.


Osteoporosis Benign paroxysmal positional vertigo Risk factors Cohort studies Case–control studies Epidemiology 



This research was supported by funding from the National Research Foundation (NRF) of Korea (NRF-2015-R1D1A1A01060860 and 2017R1C1B1007696).


This research was supported by funding from the National Research Foundation (NRF) of Korea (NRF-2018-R1D1A1A02085328 and 2017R1C1B1007696).

Compliance with ethical standards

Financial disclosure

The authors declare that they have no financial disclosure.

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of Hallym University (2014-I148) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Written informed consent was exempted by the Institutional Review Board.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal MedicineHallym University College of MedicineAnyangSouth Korea
  2. 2.Department of Orthopaedic SurgeryHallym University Sacred Heart HospitalAnyangSouth Korea
  3. 3.Department of Otorhinolaryngology-Head and Neck SurgeryHallym University College of MedicineAnyangSouth Korea
  4. 4.Department of Otorhinolaryngology-Head and Neck SurgeryCHA Bundang Medical Center, CHA University College of MedicineSeongnamSouth Korea

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