European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 1, pp 139–142 | Cite as

Olfactory function and olfactory bulb volume in Wilson’s disease

  • Nazan DegirmenciEmail author
  • Bayram Veyseller
  • Hasmet Hanagasi
  • Basar Bilgic
  • Defne Gurbuz
  • Ali Toprak
  • Orhan Ozturan



To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson’s Disease (WD) patients.


A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.


There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05).


WD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.


Wilson’s disease Olfactory dysfunction Olfactory bulb Olfaction 



This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology and Head and Neck SurgeryBezmialem Vakif UniversityIstanbulTurkey
  2. 2.Department of Otorhinolaryngology and Head and Neck Surgery, Medical FacultyAcibadem UniversityIstanbulTurkey
  3. 3.Department of Neurology, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  4. 4.Department of RadiologyOkmeydani Training and Research HospitalIstanbulTurkey
  5. 5.Department of Biostatistics and Medical InformaticsBezmialem Vakif UniversityIstanbulTurkey

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