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Systematic screening for occupations and occupational exposures in head and neck squamous cell carcinoma patients

  • Sophie Deneuve
  • Barbara Charbotel
  • Amélie Massardier-Pilonchéry
  • Emmanuel Fort
  • Charlotte Milliet-Baude
  • Olivia Pérol
  • Jérome Fayette
  • Philippe Zrounba
  • Béatrice Fervers
Head & Neck
  • 26 Downloads

Abstract

Purpose

The importance of occupational exposures in patients with head and neck squamous cell carcinomas (HNSCC) has received little attention.

Methods

In a single-center study, we prospectively characterized occupational exposures in 154 HNSCC cancer patients in a systematic occupational consultation and examined the association between most frequent exposures, HNSCC stage and localization.

Results

Patients occupied a mean of 3.3 different positions during their working life. The prevalence of asbestos, the most frequent exposure (46 patients; 29.9%) was higher than in the French population > 50 years. Other frequent exposures were solvents (n = 26; 16.9%) and silica (n = 19; 12.3%). For 37 patients (24%) a possible link was identified between occupational exposures and HNSCC. Duration of asbestos exposure was significantly higher (p = 0.04) in patients with hypopharyngeal and laryngeal cancer compared to other localizations.

Conclusions

Occupational exposures are frequent in patients with HNSCC and should receive increased attention by physicians.

Keywords

Head and neck squamous cell carcinoma Occupational exposure Environmental exposure Asbestos Professional disease 

Notes

Acknowledgements

Béatrice Fervers has received support through the Chair of excellence “Environment, Nutrition and Cancer” of the Rhône-Alpes Auvergne Cancéropôle (CLARA) and MERCK.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Sophie Deneuve
    • 1
    • 6
  • Barbara Charbotel
    • 2
    • 3
  • Amélie Massardier-Pilonchéry
    • 2
    • 3
  • Emmanuel Fort
    • 2
  • Charlotte Milliet-Baude
    • 2
  • Olivia Pérol
    • 4
  • Jérome Fayette
    • 5
  • Philippe Zrounba
    • 1
  • Béatrice Fervers
    • 4
    • 6
    • 7
  1. 1.Oncologic Surgery DepartmentLéon Bérard CenterLyonFrance
  2. 2.Université Lyon 1UMRESTTE (Unité Mixte IFSTTAR/UCBL)LyonFrance
  3. 3.Service des Maladies Professionnelles, Centre Hospitalier Lyon SudHospices Civils de LyonPierre BéniteFrance
  4. 4.Département d’Oncologie MédicaleCentre Léon BérardLyonFrance
  5. 5.Département Cancer et EnvironnementCentre Léon BérardLyonFrance
  6. 6.Centre de Recherche en Cancérologie de LyonUMR INSERM 1052-CNRS 5286LyonFrance
  7. 7.Université Lyon 1, Faculté Lyon EstUniversité de LyonLyonFrance

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