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Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere’s disease

  • Ping Guo
  • Wenfang Sun
  • Suming Shi
  • Fang zhang
  • Jiali Wang
  • Wuqing WangEmail author
Otology
  • 21 Downloads

Abstract

Purpose

To help clinicians to further understand the significance of vestibular-evoked myogenic potential (VEMP) examinations to diagnose MD and the quantitative relationship between VEMP and MRI in assessing the location and degree of endolymphatic hydrops (EH) in definite Meniere’s disease (MD) patients.

Methods

Fifty-six patients with unilateral definite MD participated in this study, which used MRIs through intravenous gadolinium administration (IV-Gd), audiometry, caloric tests and VEMP tests. The VEMP results of 26 healthy volunteers were used as a normal reference value.

Results

The participants were found through MRI to have differing degrees of vestibular and cochlear EH. Quantitative comparison of MRI and VEMP results found that the response rates of oVEMP decreased with cochlear EH increasing; the asymmetry ratio (AR) of oVEMP can be used to find whether cochlear EH or not, and the P1–N1 amplitude was lower in the extreme cochlear EH group (P < 0.01). The AR of cVEMP was larger in severe vestibular EH group than that of the mild or no vestibular EH group (P < 0.01). The correlation between the degree of cochlear EH and the mean PTA threshold was statistically significant (P < 0.05). The duration of MD correlated positively with vestibular EH (P < 0.05). The abnormal rate of caloric tests was higher in severe vestibular EH group than that of the mild or no vestibular EH group (P < 0.05).

Conclusions

The advantages of MRIs by IV-Gd administration were obvious in assessing the location and degree of EH. oVEMP and PTA can be indirectly used to evaluate the extent of cochlear EH, cVEMP and caloric tests can be used to assess the extent of vestibular EH on the condition of absent MRIs.

Keywords

Endolymphatic hydrops MRI VEMP Meniere’s disease 

Notes

Funding

This work was supported by the National Nature Science Foundation of China (Grant: 81670933 to Wuqing Wang; http://www.nsfc.gov.cn/).

Compliance with ethical standards

Conflict of interest

No potential conflict of interest relevant to this article was reported. The study’s protocol was approved by the Ethics Committee of Fudan University’s review board, and written informed consent forms were obtained from the participants.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.NHC Key Laboratory of Hearing Medicine, Department of OtolaryngologyEye Ear Nose & Throat Hospital Shanghai, Fudan UniversityShanghaiPeople’s Republic of China
  2. 2.Department of OtolaryngologyChongqing General HospitalChongqingPeople’s Republic of China
  3. 3.Department of RadiologyEye Ear Nose & Throat Hospital ShanghaiShanghaiPeople’s Republic of China

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