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Archives of Gynecology and Obstetrics

, Volume 300, Issue 6, pp 1785–1790 | Cite as

Serum zonulin level is not elevated in patients with polycystic ovary syndrome without metabolic syndrome

  • Zeynep CetinEmail author
  • Arzu Kosem
  • Bulent Can
  • Ozden Baser
  • Merve Catak
  • Turan Turhan
  • Dilek Berker
Gynecologic Endocrinology and Reproductive Medicine
  • 41 Downloads

Abstract

Aim

Polycystic ovary syndrome (PCOS) is a complex disorder with gynecological, metabolic and carcinogenic effects. Increased intestinal permeability is related with obesity, insulin resistance, type 1 and 2 diabetes mellitus. The existence of such a relationship between PCOS and intestinal permeability has come to an end. Zonulin can change intestinal permeability, and this effect is reversible. We studied the relation between zonulin and the hormonal and metabolic parameters of PCOS.

Method

A total of 45 women with PCOS and 17 healthy women were included in the study. Histories were taken from all the participants, body mass indexes were calculated, and biochemical tests and suprapubic over ultrasonography were made. Zonulin was studied with enzyme-linked immunosorbent assay.

Results

Serum zonulin levels were similar between PCOS and control groups (p = 0.893). In all participants, there were negative correlations between zonulin and the total cholesterol, LDL-cholesterol, triglycerides and non-HDL-cholesterol (respectively, p = 0.00, 0.018, 0.004, 0.002), there were boundary correlations with age and total cholesterol/HDL-cholesterol (respectively, p = 0.052 and 0.058). No statistically significant was detected in the PCOS group except negative correlation between zonulin and age (p = 0.046), boundary correlation between zonulin and total cholesterol/HDL-cholesterol (p = 0.064).

Conclusion

PCOS patients did not have metabolic syndrome. Zonulin was not higher in PCOS then controls, and it had only negative relation with age. The negative relation between zonulin and some metabolic parameters in all participants was not detected in PCOS group. So zonulin is not a useful molecule for the diagnosis of PCOS without metabolic syndrome.

Keywords

Polycystic ovary syndrome Zonulin Metabolic syndrome 

Notes

Author contributions

ZC contributed to project development, data management, manuscript writing, and data analysis. AK was involved in project development, data collection, and kit (zonulin) running. BC, OB, and MC collected the data. TT was involved in data collection and kit running. DB contributed to project development and manuscript editing.

Funding

The funding support was applied from Ankara Numune Education and Research Hospital Scientific Research Support Fund.

Compliance with ethical standards

Conflict of interest

Zeynep Cetin, Arzu Kosem, Bulent Can, Ozden Baser, Merve Catak, Turan Turhan and Dilek Berker declare that they have no conflict of interest.

Ethical approval

The local ethics committee of University of Health Sciences Ankara Numune Education and Research Hospital approved this study with ID: 1190/2017. All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study does not contain any study animals. This is a sectional study.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Endocrinology and Metabolism DepartmentAmasya University Sabuncuğlu Serefeddin Education and Research HospitalAmasyaTurkey
  2. 2.Biochemistry DepartmentAnkara City HospitalAnkaraTurkey
  3. 3.Endocrinology and Metabolism DepartmentIstanbul Civilization UniversityIstanbulTurkey
  4. 4.Endocrinology and Metabolism DepartmentYozgat City HospitalYozgatTurkey
  5. 5.Endocrinology and Metabolism DepartmentTokat Public HospitalTokatTurkey
  6. 6.Endocrinology and Metabolism DepartmentUniversity of Medical Sciences Ankara City HospitalAnkaraTurkey

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