Archives of Gynecology and Obstetrics

, Volume 300, Issue 6, pp 1729–1739 | Cite as

Identification and characterization of uterine micro-peristalsis in women undergoing in vitro fertilization and embryo transfer via dynamic ultrasound features

  • Yunfei Long
  • Rong Liang
  • Jiabin Zhang
  • Fang Fang
  • Cheng Cheng
  • Qun LuEmail author
  • Jue ZhangEmail author
Gynecologic Endocrinology and Reproductive Medicine



This study aimed to identify the existence of uterine micro-peristalsis (UMP) by dynamic ultrasound features and evaluate the feasibility of UMP as a tool to distinguish pregnant and non-pregnant infertility patients undergoing in vitro fertilization–embryo transfer (IVF–ET), using clinical pregnancy results as a benchmark.


Fifty-one women, including 29 pregnant and 22 non-pregnant patients were recruited. Also, ultrasound videos were collected before embryo transfer. First of all, undiscoverable uterine micro-peristalsis was magnified by video magnification. Then, the dynamic features of UMP were characterized by a novel index termed histogram entropy based on the micro-peristalsis feature selection by entropy weight (HEMEW), which was generated by combining frame difference and volume local phase quantization. Finally, a comparative experiment of HEMEW between non-pregnant and pregnant patients, logistic regression analysis for HEMEW and other independent clinical characteristics, and receiver operating characteristic (ROC) analysis were performed.


The magnified uterine video clearly exhibited UMP, which was invisible in the original ultrasound video. Further, there existed a significant difference in HEMEW between pregnant patients and non-pregnant patients after micro-motion magnification (p = 0.003, n = 51). The logistic regression result showed that HEMEW (p = 0.006) was significantly associated with clinical pregnancy outcome, while other independent variables had no significant effect on it. The ROC performance of HEMEW was 72.6% accuracy (AUC = 0.774, 95% CI: 0.644–0.905).


The proposed micro-motion magnification and characterization strategy identified the existences of uterine micro-peristalsis, and verified that UMP has the feasibility to distinguish the outcomes of IVF–ET.


Uterus Infertility In vitro fertilization and embryo transfer Uterine peristalsis Dynamic feature 



The authors acknowledge Beijing Municipal Science & Technology Commission for providing grants (No. Z181100001718132) from the Capital Clinical Medical Application and Development Funds.

Author contribution

YFL: project development, data management, data analysis, manuscript writing and editing, literature research. RL: project development, data collection, data analysis, manuscript writing, literature research. JBZ: project development, data management, data analysis, manuscript writing, literature research. FF: project development, data collection, data management, literature research. CC: project development, data collection, data management. QL: project development, data collection, data management, data analysis, manuscript writing, literature research. JZ: project development, data management, data analysis, manuscript writing, literature research. All authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Research involving human participants

This study was approved by the Ethics Committee of Peking University People’s Hospital (approval number: 2018PHB150-01). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

404_2019_5327_MOESM1_ESM.avi (36.1 mb)
Supplementary file1 (AVI 36936 kb)
404_2019_5327_MOESM2_ESM.avi (36.1 mb)
Supplementary file2 (AVI 36936 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.College of EngineeringPeking UniversityBeijingPeople’s Republic of China
  2. 2.Center of Reproductive MedicinePeking University People’s HospitalBeijingPeople’s Republic of China
  3. 3.Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingPeople’s Republic of China

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