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Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

  • Bianca Masturzo
  • Daniela Di Martino
  • Federico Prefumo
  • Paolo Cavoretto
  • Chiara Germano
  • Gianluca Gennarelli
  • Enrica Roletti
  • Elisa Bottazzoli
  • Federica Fusè
  • Enrico Ferrazzi
  • Danila Morano
  • Antonio FarinaEmail author
Review

Abstract

Objective

To assess the influence of maternal age on the incidence of early-onset preeclampsia requiring delivery before 34 weeks of gestation in pregnancies obtained after oocyte donation.

Methods

We carried out a prospective cohort analysis of 431 single and twin pregnancies, admitted to 3 Tertiary Referral Hospital in Northern Italy between 2008 and 2017. The rate of early-onset PE was calculated and stratified according to maternal age (from 30 to 49 years). A reference population of 11,197 single pregnancies collected prospectively at the first trimester of pregnancy in the same geographic area of Italy and in same hospitals was used to calculate the expected incidence of early-onset PE.

Results

In women who delivered after 24 weeks of gestation, the rate of early-onset PE was much higher in oocyte-donation pregnancies, reaching 6.7% (29/431), than the expected rate of 0.5% of the cohort of reference. The mean early PE rate was 4.1% (10/242) in singletons and 10.1% (19/189) in twin pregnancies. According to maternal age, the rate of early PE was 1.16% and 3.12% at 30 years, and 4.98% and 13.14% at 49 years in single and twin pregnancies obtained after oocyte donation, respectively.

Conclusion

Pregnancies obtained after oocyte donation delivering after 24 weeks had a higher risk of early-onset PE requiring delivery before 34 weeks of gestation, than the general population. The risk is directly correlated with the increase of maternal age and is also higher in twin pregnancies.

Keywords

Oocyte-donor pregnancy Early-onset preeclampsia Maternal age-related risk Binary logistic regression 

Notes

Author contributions

BM: protocol/project development, data collection, manuscript writing. DDM: protocol/project development. FP: data collection. PC: data collection. CG: protocol/project development, data collection, manuscript writing. GG: Protocol/project development, data collection. ER: protocol/project development, data collection. EB: data collection. FF: data collection. EF: protocol/project development. DM: protocol/project development, manuscript writing. AF: protocol/project development, data collection, manuscript writing, data analysis.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The committee for this study is Professor Antonio Farina.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

404_2019_5291_MOESM1_ESM.docx (13 kb)
Supplementary file1 (DOCX 12 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Bianca Masturzo
    • 1
  • Daniela Di Martino
    • 2
  • Federico Prefumo
    • 3
  • Paolo Cavoretto
    • 4
  • Chiara Germano
    • 1
  • Gianluca Gennarelli
    • 1
  • Enrica Roletti
    • 5
  • Elisa Bottazzoli
    • 6
  • Federica Fusè
    • 6
  • Enrico Ferrazzi
    • 2
  • Danila Morano
    • 7
  • Antonio Farina
    • 8
    Email author
  1. 1.Department of Surgical Sciences, OIRM S. Anna HospitalUniversity of TurinTurinItaly
  2. 2.Fondazione IRCCS Ca’ Granda, Ospedale Maggiore PoliclinicoMilanItaly
  3. 3.Department of Obstetrics and GynecologyUniversity of BresciaBresciaItaly
  4. 4.Gynecology and Obstetrics Department, IRCCS San Raffaele HospitalVita-Salute UniversityMilanItaly
  5. 5.Gynecology and Obstetrics DepartmentMaggiore University HospitalParmaItaly
  6. 6.Department of Woman, Mother and Neonate, Buzzi Children’s HospitalUniversity of MilanMilanItaly
  7. 7.Department of Obstetrics and GynecologySant’Anna University HospitalFerraraItaly
  8. 8.Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant’Orsola-Malpighi HospitalUniversity of BolognaBolognaItaly

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