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Archives of Gynecology and Obstetrics

, Volume 300, Issue 3, pp 641–645 | Cite as

Influence of a mannose-binding lectin gene polymorphism and exposure to Chlamydia trachomatis on fallopian tube obstruction in Brazilian woman

  • Joao G. Vinagre
  • Steven S. WitkinEmail author
  • Sergio C. Ribeiro
  • Renata Robial
  • Eiko I. Fukazawa
  • Carla C. Ortolani
  • Edmund C. Baracat
  • Iara M. Linhares
General Gynecology
  • 31 Downloads

Abstract

Purpose

Factors influencing fallopian tube occlusion in women with a lower genital tract infection remain incompletely elucidated. We evaluated whether a polymorphism in the mannose-binding lectin (MBL) gene at codon 54 influences the occurrence of fallopian tube blockage in relation to exposure to Chlamydia trachomatis.

Methods

In a case–control study at The Hospital das Clínicas, University of São Paulo, Brazil, 75 women with hysterosalpingography-documented tubal occlusion and 75 women with patent fallopian tubes were analyzed for detection of single-nucleotide polymorphism in codon 54 of the MBL gene and for IgG anti-C. trachomatis antibodies in their sera. Both groups were matched for age, race, and sexual variables.

Results

Prior exposure to C. trachomatis, as evidenced by the presence of IgG antibodies, was comparable in both groups. Detection of the polymorphic MBL allele was more prevalent in women with blocked tubes (p < 0.01), regardless of whether or not there was evidence of prior chlamydial exposure.

Conclusion

The level of MBL-related innate immunity influences the consequences of infection by C. trachomatis or other microbes.

Keywords

Chlamydia trachomatis Fallopian tube occlusion Genetic polymorphism Innate immunity Mannose-binding lectin 

Notes

Author contribution

JGV, SCR, IML: trial conception and design, wrote original draft. EIF, RR, JGV, CCO: patient recruitment, sample collection, initial data analysis. IML, SSW: final data analysis and interpretation, wrote final version of manuscript. IML, ECB: study supervision.

Compliance with ethical standards

Conflict of Interest

None of the authors report any conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Gynecology and ObstetricsUniversity of Sao Paulo Medical SchoolSao PauloBrazil
  2. 2.Department of Obstetrics and GynecologyWeill Cornell MedicineNew YorkUSA
  3. 3.Institute of Tropical MedicineUniversity of Sao Paulo Medical SchoolSao PauloBrazil

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