Advertisement

Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies

  • Giovanni SistiEmail author
  • Sara Paccosi
  • Astrid Parenti
  • Viola Seravalli
  • Mariarosaria Di Tommaso
  • Steven S. Witkin
Maternal-Fetal Medicine

Abstract

Purpose

Mechanisms leading to preterm premature rupture of membranes (PPROM) remain incompletely defined. Based on the elevated occurrence of PPROM in twin gestations and recent studies of the involvement of insulin-like growth factor binding protein-1 (IGFBP-1) in the inhibition of collagen production we hypothesized that serum IGFBP-1 levels might be predictive of susceptibility to PPROM in women with twins.

Methods

In this prospective study peripheral blood was obtained from 58 women with twin gestations prior to 20 weeks gestation and sera analyzed by ELISA for concentrations of IGFBP-1. Demographic and clinical outcome data were subsequently obtained and associations between IGFBP-1 and PPROM were analyzed by the Mann–Whitney test and receiver operator curve (ROC) analysis.

Results

Eight of our subjects developed PPROM. They did not differ from the other women in demographics, medical history or current pregnancy outcome parameters. However, median IGFBP-1 levels were higher in women who subsequently developed PPROM (59.3 ng/ml) than in the other women (46.6 ng/ml) (p = 0.042). Using a cutoff value of 53.9 ng/ml the circulating IGFBP-1 level predicted development of PPROM with a sensitivity of 74%, specificity of 75%, a negative predictive value of 97% and a positive predictive value of 20%.

Conclusions

Pending validation in larger studies the findings suggest that determination of serum IGFBP-1 levels in women with twin pregnancies may predict the later development of PPROM.

Keywords

Insulin-like growth factor binding protein Preterm premature rupture of membranes Twins Sera 

Notes

Author contributions

GS: project development, data collection, and manuscript writing. SP: samples management, data analysis. AP: data collection. VS: manuscript writing. MDT: project development, and manuscript writing. SW: data analysis, and manuscript writing.

Compliance with ethical standards

Conflict of interest

We declare that we have no conflict of interest.

References

  1. 1.
    Mercer BM (2003) Preterm premature rupture of the membranes. Obstet Gynecol 101:178–193Google Scholar
  2. 2.
    Parry S, Strauss JF (1998) Premature rupture of the fetal membranes. N Eng J Med 338:663–670CrossRefGoogle Scholar
  3. 3.
    Menon R, Fortunato SJ, Yu J, Milne GL, Sanchez S, Drobek CO et al (2011) Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes. Placenta 32:317–322CrossRefGoogle Scholar
  4. 4.
    Woods JR (2001) Reactive oxygen species and preterm premature rupture of membranes—a review. Placenta 22(Suppl A):S38–S44Google Scholar
  5. 5.
    Melamed N, Hadar E, Ben-Harhoush A, Kaplan B, Yogev Y (2009) Factors affecting the duration of the latency period in preterm premature rupture of membranes. J Matern Fetal Neonatal Med 22:1051–1056CrossRefGoogle Scholar
  6. 6.
    Kibel M, Barrett J, Tward C, Pittini A, Kahn M, Melamed N (2017) The natural history of preterm premature rupture of membranes in twin pregnancies. J Matern Neonatal Fetal Med 30(15):1829–1835CrossRefGoogle Scholar
  7. 7.
    Clemmons DR, Busby W, Clarke JB, Parker A, Duan C, Nam TJ (1998) Modification of insulin-like growth factor binding proteins and their role in controlling IGF actions. Endocrine J 45(Suppl):S1–S8CrossRefGoogle Scholar
  8. 8.
    Novosyadlyy R, Lelbach A, Sheikh N, Tron K, Pannem R, Ramadori G et al (2009) Temporal and spacial expression of IGF-1 and IGFBP-1 during acute-phase response induced by local inflammation in rats. Growth Hormon IGF Res 19:51–60CrossRefGoogle Scholar
  9. 9.
    Gillery P, Leperre A, Maquart FX, Borel JP (1992) Insulin-like growth factor-1 (IGF-1) stimulates protein synthesis and collagen gene expression in monolayer and lattice cultures of fibroblasts. J Cell Physiol 152:389–396CrossRefGoogle Scholar
  10. 10.
    Prokop I, Kononczuk J, Surazynski A, Palka J (2013) Cross-talk between integrin receptor and insulin-like growth factor receptor in regulation of collagen biosynthesis in cultured fibroblasts. Adv Med Sci 58:292–297CrossRefGoogle Scholar
  11. 11.
    Abbas A, Johnson M, Chard T, Nicolaides KH (1995) Maternal plasma concentrations of insulin-like growth factor binding protein-1 and placental protein 14 in multifetal pregnancies before and after fetal reduction. Hum Reprod. 10(1):207–210CrossRefGoogle Scholar
  12. 12.
    Committee on Practice Bulletins-Obstetrics (2018) ACOG practice bulletin no. 188: prelabor rupture of membranes. Obstet Gynecol 131(1):e1–e14CrossRefGoogle Scholar
  13. 13.
    Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T (2019) IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1. J Clin Endocrinol Metab 104(2):408–422CrossRefGoogle Scholar
  14. 14.
    Wang HS, Lee JD, Cheng BJ, Soong YK (1996) Insulin-like growth factor-binding protein 1 and insulin-like growth factor-binding protein 3 in pre-eclampsia. Br J Obstet Gynaecol 103(7):654–659CrossRefGoogle Scholar
  15. 15.
    Stone S, Langford K, Seed PT, Khamashta MA, Hunt BJ, Poston L (2003) Longitudinal analysis of serum insulin-like growth factor-I and insulin-like growth factor binding protein-1 in antiphospholipid syndrome and in healthy pregnancy. Am J Obstet Gynecol. 189(1):274–279CrossRefGoogle Scholar
  16. 16.
    Fowler D, Albaiges G, Lees C, Jones J, Nicolaides K, Miell J (1999) The role of insulin-like growth factor binding protein-1 phosphoisoforms in pregnancies with impaired placental function identified by doppler ultrasound. Hum Reprod. 14(11):2881–2885CrossRefGoogle Scholar
  17. 17.
    Darj EG, Lyrenas S (1998) insulin-like growth factor binding protein-1, a quick way to detect amniotic fluid. Acta Obstet Gynecol Scand 77:295–297CrossRefGoogle Scholar
  18. 18.
    Chen CY, Chang CC, Lin CW (2015) Clinical application of immunomagnetic reduction for quantitative measurement of insulin-like growth factor binding protein-1 in the prediction of pregnant women with preterm premature rupture of membranes. Clin Chim Acta 438:337–341CrossRefGoogle Scholar
  19. 19.
    Abdelazim IA (2014) Insulin-like growth factor binding protein-1 (Actim PROM test®) for detection of premature rupture of fetal membranes. J Obstet Gynecol Res. 40(4):961–967CrossRefGoogle Scholar
  20. 20.
    Abdelazim IA, Makhlouf HH (2013) Placental alpha microglobulin-1 (AmniSure test®) versus Insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes. J Obstet Gynecol Res. 39(6):1129–1136CrossRefGoogle Scholar
  21. 21.
    Abdelazim IA, Al-Sherbeeny MM, Ibrahim ME, Fahmy AA, Rabei NH et al (2016) Insulin-like growth factor binding protein-1/ alpha-fetoprotein versus placental alpha microglobulin-1 for diagnosis of premature fetal membranes rupture. Acta Med Int 3(1):69–74CrossRefGoogle Scholar
  22. 22.
    Abu-Faza M, Abdelazim IA, Svetlana S, Nusair B, Farag R et al (2018) Diagnostic accuracy of PremaQuick versus actim partus in prediction of preterm labor in symptomatic women within 14 days. Open J Obstet Gynecol 8(8):741–755CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyLincoln Medical and Mental Health CenterBronxUSA
  2. 2.Department of Obstetrics and GynecologyWeill Cornell MedicineNew YorkUSA
  3. 3.Department of Health SciencesUniversity of FlorenceFlorenceItaly
  4. 4.Department of Health Sciences, Obstetrics and Gynecology BranchUniversity of FlorenceFlorenceItaly

Personalised recommendations