Cesarean section and the risk of neonatal respiratory distress syndrome: a meta-analysis
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To explore the association between cesarean section (CS) and the risk of neonatal respiratory distress syndrome (RDS).
We searched PubMed, Web of Science, and ClinicalTrials.gov database for studies related to the association between CS and the risk of neonatal RDS up to 25 August 2018. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using a random-effects model (REM).
A total of 26 studies from 25 available articles were included in this meta-analysis. For the association between CS and the risk of neonatal RDS, the pooled OR was 1.76 (95% CI 1.48–2.09). The pooled OR of the risk of neonatal RDS was 2.38 (95% CI 1.89–2.99) for elective CS and 1.85 (95% CI 1.34–2.56) for emergency CS.
This meta-analysis suggested that CS, elective CS, and emergency CS were associated with an increased risk of neonatal RDS.
KeywordsCesarean section Epidemiology studies Meta-analysis Neonatal respiratory distress syndrome
YL: conceived the study, designed the study, drafted the manuscript, carried out the literature search and data extraction, interpreted the result of the analysis, and reviewed and revised the manuscript critically. CZ: carried out the literature search and data extraction, interpreted the result of the analysis, and reviewed and revised the manuscript critically. DZ: conceived the study, designed the study, drafted the manuscript, and reviewed and revised the manuscript critically. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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