Gestational age-specific risk of stillbirth during term pregnancy according to maternal age
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To investigate the gestational age-specific risk of stillbirth according to the maternal age group particularly regarding stillbirth risk at the end of pregnancy.
This study was a retrospective national cohort study of all singleton term pregnancy using the Korean Vital Statistics database (n = 2,798,542). We evaluated the risk of stillbirth by gestational week in mothers aged 20–49 years according to maternal age group and neonatal birth weight.
The risk of stillbirth in women aged 41 years and older was significantly higher than in women aged 20–29 years between 37 and 40 weeks’ gestation. The stillbirth rate per 10,000 ongoing pregnancy in women aged 37–38 years at 39 weeks’ gestation (4.22, 95% confidence intervals [CI] 3.01–5.90) and that in women aged 39–40 years at 40 weeks’ gestation (8.15, 95% CI 4.83–13.77) were significantly higher in comparison with in those aged 20–29 years at 39 weeks’ gestation (1.95, 95% CI 1.64–2.33) and at 40 weeks’ gestation (2.59, 95% CI 2.1–3,18). The risk of stillbirth showed an increasing pattern at 40 gestational weeks, in women aged 39 years and older.
Delivery plan need to be set up and supported to decrease rates of stillbirth at term in women aged 35 years and older with other risk factors and in women aged 37 years and older regardless of risk factors, and especially in women older than 40 years of age.
KeywordsStillbirth Maternal age Delivery Obstetrics Gestational age
The authors wish to acknowledge the technical support of DH, Kim for statistics.
HSK designed the study and participated in acquisition and interpretation of data. JHW was the first author and participated in drafting of manuscript. HSK is the corresponding author. YGP participated in statistical analysis. SEP, RYK, YHC participated in data acquisition. IYP and JCS were participated in supervision and methodology. All authors have read and approved the final manuscript.
No external funding was received for this study.
Compliance with ethical standards
Conflict of interest
All authors have no conflict of interest related with this article.
We obtained approval from the institutional review board of Catholic University of Korea (KC17ZESI0171).
Availability of data and materials
All data supporting the conclusion of the article are available from the corresponding author on reasonable request.
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