Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis
The association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk.
PubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs).
A total of 18 case–control studies were included in the meta-analysis. We found that there was no statistical significance for ovarian cancer risk following hysterectomy (OR 0.97, 95% CI 0.83–1.12). And in subgroup analysis, the protective effects were observed for invasive endometrioid/clear cell carcinomas after hysterectomy (OR 0.70, 95% CI 0.51, 0.94; I2 = 0%), and no statistical significance for serous and mucinous.
Hysterectomy showed no relationship with ovarian cancer. But a reduced risk was found for endometrioid-invasive OC. These findings could provide evidence for patients with benign gynecological disease and clinicians to make appropriate decision about whether to conduct hysterectomy.
KeywordsHysterectomy Ovarian cancer Risk Meta-analysis
This study was funded by the National Natural Science Foundation of China (Project No. 81560426) and the Research Project of Gansu Provincial People’s Hospital in China (No. 16GSSY6-8).
XH and LY: Project development, data collection, manuscript writing/editing. XH and WL: Project development, data analysis, manuscript editing. JL, LZ and YG: Project development. KY and HL: Project development, manuscript editing.
Compliance with ethical standards
Conflict of interest
No conflict of interest.
- 5.de Bruijn AM, Ankum WM, Reekers JA, Birnie E, van der Kooij SM, Volkers NA et al (2016) Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 10-year outcomes from the randomized emmy trial. Am J Obstet Gynecol 215(6) 745:e741–e745 (e712) Google Scholar
- 19.Wells GA, Shea BJ, O'Connell D, Peterson J, Welch V, Losos M et al (2014) The newcastle–ottawa scale (nos) for assessing the quality of non-randomized studies in meta-analysis. Appl Eng Agric 18(6):727–734Google Scholar
- 31.Pajenga E, Rexha T, Çeliku S, Bejtja G, Pisha M (2013) Hormonal risk factors for ovarian cancer in the albanian case–control study. Bos J Basic Med Sci 13(2):89–93Google Scholar
- 35.Kupelian V, Davis F, Mallin K, Rosenblatt K (2000) Tubal sterilization, hysterectomy and risk of ovarian cancer: a case–control study. Am J Epidemiol 151(11):S69–S69Google Scholar