Archives of Gynecology and Obstetrics

, Volume 299, Issue 3, pp 599–607 | Cite as

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis

  • Xiaqin Huo
  • Liang Yao
  • Xue Han
  • Wen Li
  • Junjuan Liu
  • Lijun Zhou
  • Yuanfeng Gou
  • Kehu YangEmail author
  • Huiling LiuEmail author



The association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk.


PubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs).


A total of 18 case–control studies were included in the meta-analysis. We found that there was no statistical significance for ovarian cancer risk following hysterectomy (OR 0.97, 95% CI 0.83–1.12). And in subgroup analysis, the protective effects were observed for invasive endometrioid/clear cell carcinomas after hysterectomy (OR 0.70, 95% CI 0.51, 0.94; I2 = 0%), and no statistical significance for serous and mucinous.


Hysterectomy showed no relationship with ovarian cancer. But a reduced risk was found for endometrioid-invasive OC. These findings could provide evidence for patients with benign gynecological disease and clinicians to make appropriate decision about whether to conduct hysterectomy.


Hysterectomy Ovarian cancer Risk Meta-analysis 



This study was funded by the National Natural Science Foundation of China (Project No. 81560426) and the Research Project of Gansu Provincial People’s Hospital in China (No. 16GSSY6-8).

Author contributions

XH and LY: Project development, data collection, manuscript writing/editing. XH and WL: Project development, data analysis, manuscript editing. JL, LZ and YG: Project development. KY and HL: Project development, manuscript editing.

Compliance with ethical standards

Conflict of interest

No conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Gynecology and ObstetricsGansu Provincial People’s HospitalLanzhouPeople’s Republic of China
  2. 2.Department of Clinical MedicineGansu University of Traditional Chinese MedicineLanzhouPeople’s Republic of China
  3. 3.Evidence-Based Medicine Center, School of Basic Medical SciencesLanzhou UniversityLanzhouPeople’s Republic of China
  4. 4.Institution of Clinical Research and Evidence Based MedicineGansu Provincial HospitalLanzhouPeople’s Republic of China

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