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Malignant transformation of adenomyosis: literature review and meta-analysis

  • Hang Yuan
  • Shiqian Zhang
Review
  • 26 Downloads

Abstract

Purpose

To review and analyze risk factors and the pathology of malignant transformation of adenomyosis.

Methods

In this paper, the relevant research on current risks factors and the pathology of malignant transformation of adenomyosis was reviewed and analyzed by metaanalysis. All studies included were retrieved from the PUBMED.

Results

Analysis of existing studies revealed that most malignant transformation of adenomyosis occurs in elderly or postmenopausal patients. Adenomyosis with uterine leiomyoma or benign endometrial hyperplasia and other benign diseases appears to be more prone to malignancy, but there is currently no strong evidence to confirm this finding.

Conclusions

At present, the malignant transformation of adenomyosis is thought to be due to its endometrial epithelium transition to monolayer tumor cells before malignant transformation, which eventually develops to varying degrees of cancer. However, the specific molecular mechanism of adenomyosis is not yet clear. Because of its low incidence of malignant transformation, lack of large-sample, multi-center clinical trials, and large heterogeneity of the existing research, the evidence based on the high-risk factors of malignant transformation of adenomyosis is weak.

Keywords

Adenomyosis Malignant transformation Meta-analysis 

Notes

Author contributions

HY Data Collection, Manuscript writing. SZ Data Collection, Manuscript writing

Compliance with ethical standards

Conflict of interest

Hang Yuan declares that she has no conflict of interest. Shiqian Zhang declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Koike N, Tsunemi T, Uekuri C, Akasaka J, Ito F, Shigemitsu A, Kobayashi H (2013) Pathogenesis and malignant transformation of adenomyosis (review). Oncol Rep 29:861–867 (Published online EpubMar (10.3892/or.2012.2184)) CrossRefPubMedGoogle Scholar
  2. 2.
    Taran FA, Stewart EA, Brucker S (2013) Adenomyosis: epidemiology, risk factors, clinical phenotype and surgical and interventional alternatives to hysterectomy. Geburtshilfe und Frauenheilkunde 73:924–931 (Published online EpubSep (10.1055/s-0033-1350840)) CrossRefPubMedCentralPubMedGoogle Scholar
  3. 3.
    Hong SC, Khoo CK (2016) An update on adenomyosis uteri. Gynecol Min Invas Ther 5:106–108.  https://doi.org/10.1016/j.gmit.2015.08.003 CrossRefGoogle Scholar
  4. 4.
    Ismiil ND, Rasty G, Ghorab Z, Nofech-Mozes S, Bernardini M, Thomas G, Ackerman I, Covens A, Khalifa MA (2007) Adenomyosis is associated with myometrial invasion by FIGO 1 endometrial adenocarcinoma. Int J Gynecol Pathol 26:278–283.  https://doi.org/10.1097/01.pgp.0000235064.93182.ec CrossRefPubMedGoogle Scholar
  5. 5.
    Mori M, Furusawa A, Kino N, Uno M, Ozaki Y, Yasugi T (2015) Rare case of endometrioid adenocarcinoma arising from cystic adenomyosis. J Obstet Gynaecol Res 41:324–328 (Published online EpubFeb 10.1111/jog.12513) CrossRefPubMedGoogle Scholar
  6. 6.
    Kazandi M, Zeybek B, Terek MC, Zekioglu O, Ozdemir N, Oztekin K (2010) Grade 2 endometrioid adenocarcinoma arising from adenomyosis of the uterus: report of a case. Eur J Gynaecol Oncol 31:719–721PubMedGoogle Scholar
  7. 7.
    Hsu MI, Chou SY, Lin SE, Liang SJ, Chiu HC, Hsu CS (2006) Very early stage adenocarcinoma arising from adenomyosis in the uterus. Taiwan J Obstet Gynecol 45:346–349 (Published online EpubDec (10.1016/s1028-4559(09)60258-8)) CrossRefPubMedGoogle Scholar
  8. 8.
    Matsuo K, Moeini A, Machida H, Scannell CA, Casabar JK, Kakuda M, Adachi S, Garcia-Sayre J, Ueda Y, Roman LD (2016) Tumor characteristics and survival outcome of endometrial cancer arising in adenomyosis: an exploratory analysis. Ann Surg Oncol 23:959–967 (Published online EpubMar (10.1245/s10434-015-4952-y)) CrossRefPubMedGoogle Scholar
  9. 9.
    Ismiil N, Rasty G, Ghorab Z, Nofech-Mozes S, Bernardini M, Ackerman I, Thomas G, Covens A, Khalifa MA (2007) Adenomyosis involved by endometrial adenocarcinoma is a significant risk factor for deep myometrial invasion. Annals of diagnostic pathology 11:252–257 (Published online epubaug (10.1016/j.anndiagpath.2006.08.011)) CrossRefPubMedGoogle Scholar
  10. 10.
    Koshiyama M, Okamoto T, Ueta M (2004) The relationship between endometrial carcinoma and coexistent adenomyosis uteri, endometriosis externa and myoma uteri. Cancer Detect Prev 28:94–98.  https://doi.org/10.1016/j.cdp.2003.12.008 CrossRefPubMedGoogle Scholar
  11. 11.
    Taneichi A, Fujiwara H, Takahashi Y, Takei Y, Machida S, Saga Y, Takahashi S, Suzuki M (2014) Influences of uterine adenomyosis on muscle invasion and prognosis of endometrioid adenocarcinoma. Int J Gynecol Cancer 24:1429–1433 (Published online EpubOct (10.1097/IGC.0000000000000243)) CrossRefPubMedGoogle Scholar
  12. 12.
    Genc M, Genc B, Cengiz H (2015) Adenomyosis and accompanying gynecological pathologies. Arch Gynecol Obstet 291:877–881 (Published online EpubApr (10.1007/s00404-014-3498-8)) CrossRefPubMedGoogle Scholar
  13. 13.
    Baba A, Yamazoe S, Dogru M, Ogawa M, Takamatsu K, Miyauchi J (2016) Clear cell adenocarcinoma arising from adenomyotic cyst: A case report and literature review. The journal of obstetrics and gynaecology research 42:217–223 (Published online EpubFeb (10.1111/jog.12866)) CrossRefPubMedGoogle Scholar
  14. 14.
    Lu B, Chen Q, Zhang X, Cheng L (2016) Serous carcinoma arising from uterine adenomyosis/adenomyotic cyst of the cervical stump: a report of 3 cases. Diagn Pathol 11:46 (Published online EpubJun 04 (10.1186/s13000-016-0496-0)) CrossRefPubMedCentralPubMedGoogle Scholar
  15. 15.
    Izadi-Mood N, Samadi N, Sarmadi S, Eftekhar Z (2007) Papillary serous carcinoma arising from adenomyosis presenting as intramural leiomyoma. Arch Iran Med 10:258–260 (Published online EpubApr (07102/aim.0026)) PubMedGoogle Scholar
  16. 16.
    Matsuo K, Cahoon SS, Gualtieri M, Scannell CA, Jung CE, Takano T, Paulson RJ, Muderspach LI, Roman LD (2014) Significance of adenomyosis on tumor progression and survival outcome of endometrial cancer. Ann Surg Oncol 21:4246–4255 (Published online EpubDec (10.1245/s10434-014-3880-6)) CrossRefPubMedGoogle Scholar
  17. 17.
    Goumenou AG, Arvanitis DA, Matalliotakis IM, Koumantakis EE, Spandidos DA (2000) Loss of heterozygosity in adenomyosis on hMSH2, hMLH1, p16Ink4 and GALT loci. International journal of molecular medicine 6:667–671 (Published online EpubDec) PubMedGoogle Scholar
  18. 18.
    Jones RK, Searle RF, Bulmer JN (1998) Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis. Hum Reprod (Oxford, England) 13:3496–3502 (Published online EpubDec) CrossRefGoogle Scholar
  19. 19.
    Jichan N, Xishi L, Guo SW (2010) Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent. Reprod Sci 17:995–1005 (Published online EpubNov (10.1177/1933719110377118)) CrossRefGoogle Scholar
  20. 20.
    Sampson JA (1925) Endometrial carcinoma of the ovary arising in endometrial tissue of that organ. Arch Surg 10:1–72CrossRefGoogle Scholar
  21. 21.
    Colman HI, Rosenthal AH (1959) Carcinoma developing in areas of adenomyosis. Obset Gynecol 14:342–348Google Scholar
  22. 22.
    Gizzo S, Patrelli TS, Dall’asta A, DI Gangi S, Giordano G, Migliavacca C, Monica M, Merisio C, Nardelli GB, Quaranta M, Noventa M, Berretta R (2016) Coexistence of adenomyosis and endometrioid endometrial cancer: role in surgical guidance and prognosis estimation. Oncol Lett 11(2):1213–1219 (Epub 2015 Dec 15) CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of GynecologyQilu Hospital of Shandong UniversityJinanChina

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