Malignant transformation of adenomyosis: literature review and meta-analysis
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To review and analyze risk factors and the pathology of malignant transformation of adenomyosis.
In this paper, the relevant research on current risks factors and the pathology of malignant transformation of adenomyosis was reviewed and analyzed by metaanalysis. All studies included were retrieved from the PUBMED.
Analysis of existing studies revealed that most malignant transformation of adenomyosis occurs in elderly or postmenopausal patients. Adenomyosis with uterine leiomyoma or benign endometrial hyperplasia and other benign diseases appears to be more prone to malignancy, but there is currently no strong evidence to confirm this finding.
At present, the malignant transformation of adenomyosis is thought to be due to its endometrial epithelium transition to monolayer tumor cells before malignant transformation, which eventually develops to varying degrees of cancer. However, the specific molecular mechanism of adenomyosis is not yet clear. Because of its low incidence of malignant transformation, lack of large-sample, multi-center clinical trials, and large heterogeneity of the existing research, the evidence based on the high-risk factors of malignant transformation of adenomyosis is weak.
KeywordsAdenomyosis Malignant transformation Meta-analysis
HY Data Collection, Manuscript writing. SZ Data Collection, Manuscript writing
Compliance with ethical standards
Conflict of interest
Hang Yuan declares that she has no conflict of interest. Shiqian Zhang declares that he has no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 4.Ismiil ND, Rasty G, Ghorab Z, Nofech-Mozes S, Bernardini M, Thomas G, Ackerman I, Covens A, Khalifa MA (2007) Adenomyosis is associated with myometrial invasion by FIGO 1 endometrial adenocarcinoma. Int J Gynecol Pathol 26:278–283. https://doi.org/10.1097/01.pgp.0000235064.93182.ec CrossRefGoogle Scholar
- 6.Kazandi M, Zeybek B, Terek MC, Zekioglu O, Ozdemir N, Oztekin K (2010) Grade 2 endometrioid adenocarcinoma arising from adenomyosis of the uterus: report of a case. Eur J Gynaecol Oncol 31:719–721Google Scholar
- 8.Matsuo K, Moeini A, Machida H, Scannell CA, Casabar JK, Kakuda M, Adachi S, Garcia-Sayre J, Ueda Y, Roman LD (2016) Tumor characteristics and survival outcome of endometrial cancer arising in adenomyosis: an exploratory analysis. Ann Surg Oncol 23:959–967 (Published online EpubMar (10.1245/s10434-015-4952-y)) CrossRefGoogle Scholar
- 9.Ismiil N, Rasty G, Ghorab Z, Nofech-Mozes S, Bernardini M, Ackerman I, Thomas G, Covens A, Khalifa MA (2007) Adenomyosis involved by endometrial adenocarcinoma is a significant risk factor for deep myometrial invasion. Annals of diagnostic pathology 11:252–257 (Published online epubaug (10.1016/j.anndiagpath.2006.08.011)) CrossRefGoogle Scholar
- 11.Taneichi A, Fujiwara H, Takahashi Y, Takei Y, Machida S, Saga Y, Takahashi S, Suzuki M (2014) Influences of uterine adenomyosis on muscle invasion and prognosis of endometrioid adenocarcinoma. Int J Gynecol Cancer 24:1429–1433 (Published online EpubOct (10.1097/IGC.0000000000000243)) CrossRefGoogle Scholar
- 15.Izadi-Mood N, Samadi N, Sarmadi S, Eftekhar Z (2007) Papillary serous carcinoma arising from adenomyosis presenting as intramural leiomyoma. Arch Iran Med 10:258–260 (Published online EpubApr (07102/aim.0026)) Google Scholar
- 16.Matsuo K, Cahoon SS, Gualtieri M, Scannell CA, Jung CE, Takano T, Paulson RJ, Muderspach LI, Roman LD (2014) Significance of adenomyosis on tumor progression and survival outcome of endometrial cancer. Ann Surg Oncol 21:4246–4255 (Published online EpubDec (10.1245/s10434-014-3880-6)) CrossRefGoogle Scholar
- 17.Goumenou AG, Arvanitis DA, Matalliotakis IM, Koumantakis EE, Spandidos DA (2000) Loss of heterozygosity in adenomyosis on hMSH2, hMLH1, p16Ink4 and GALT loci. International journal of molecular medicine 6:667–671 (Published online EpubDec) Google Scholar
- 21.Colman HI, Rosenthal AH (1959) Carcinoma developing in areas of adenomyosis. Obset Gynecol 14:342–348Google Scholar
- 22.Gizzo S, Patrelli TS, Dall’asta A, DI Gangi S, Giordano G, Migliavacca C, Monica M, Merisio C, Nardelli GB, Quaranta M, Noventa M, Berretta R (2016) Coexistence of adenomyosis and endometrioid endometrial cancer: role in surgical guidance and prognosis estimation. Oncol Lett 11(2):1213–1219 (Epub 2015 Dec 15) CrossRefGoogle Scholar