Extraparenchymal ovarian and testicular Leydig cells: ectopic/heterotopic or orthotopic?
- 18 Downloads
We are conducting a prospective study trying to determine, in both sexes, the frequency of appearance of ectopic Leydig cells, their preferred location, their relationship with nerve structures and the possible causes of their appearance.
We have studied 86 cases that were removed according to different clinical indications for pathological study: uterine leyomiomas (n = 12), ovarian cystadenoma (n = 4), endometrial hyperplasia (n = 8), endometrial carcinoma (n = 12), cervical carcinoma (n = 4), seminoma (n = 4), fallopian tube ligatures (n = 24), vasectomies (n = 8), nonspecific orchiepididymitis (n = 2), and unknown (n = 8).
We have observed ectopic Leydig cells in 13/86 cases (15.11%), 9/72 in the female samples (12.50%) and 4/14 in male samples (28.57%). The most frequent location was the mesosalpinx (4 of 13: 30.76%).
These high figures lead us to believe that the ectopia of Leydig cells is not really a pathologic entity, but a finding related to specific functions yet to be determined.
KeywordsLeydig cells Extraparenchymal Ectopia Heterotopia Orthotopia
The authors would like to thank Patrick Dennis for revising the English language in this manuscript. This work has been possible thanks to the existing research agreement between the University of La Laguna and the Clinical Laboratory Dr. Gonzalez Santiago (CI02020401).
JLC: project development, data collection, manuscript writing. HÁ: project development, data collection, manuscript writing. CM: project development, manuscript writing. RG: project development, manuscript writing. AV: project development, data collection. IE: project development, data collection. RM: project development, data collection. LD: project development, data collection, manuscript writing.
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Institutional Ethics Committee of the University of La Laguna approved this study (CEIBA2018-0289).
Additional informed consent was not required since our standard hospital consent form for surgical or other procedure specifically states that “I understand that the Hospital may use for teaching or scientific purposes, or may otherwise dispose of, tissues, fluids or organs removed during the procedure”.
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Trainer TD (1997) Testis and excretory duct system. In: Sternberg SS (ed) Histology for pathologists, 2nd edn. Lippincott-Raven, Philadelphia, pp 1019–1038Google Scholar
- 7.Ulbright TM, Amin MB, Young RH (1999) Tumor-like lesions of testis, paratestis, and spermatic cord. In: Rosai J, Sobin LH (eds) Atlas of tumor pathology. Tumors of the testis, adnexa, spermatic cord, and scrotum. Armed Forces Institute of Pathology [3rd series. Fascicle 25], Washington DC, pp 291–342Google Scholar
- 8.Verocay J (1915) Hat Unwegsamkeit des Ductus deferens Atrophie des Hodens zur Folge? Prag Med Wchschr 40:113–115Google Scholar
- 18.Berger L (1922) Sur l´existence de glands sympathicotropes dans l´ovaire et le testicule humains; leur rapport avec la glande interstitielle du testicule. Compt Rend Acad Sci Paris 175:907–909Google Scholar
- 26.Regadera J, Cobo P, Martínez-García F, Nistal M, Paniagua R (1993) Testosterone immunoexpression in human Leydig cells of the tunica albuginea testis and spermatic cord. A quantitative study in normal foetuses, young adults, elderly men and patients with cryptorchidism. Andrologia 25:115–122CrossRefPubMedGoogle Scholar
- 27.Jost A (1953) Problems of fetal endocrinology: the gonadal and hypophyseal hormones. Recent Prog Horm Res 8:379–418Google Scholar