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Is there a relationship between endometrial polyps and obesity, diabetes mellitus, hypertension?

  • General Gynecology
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Abstract

Objective

The purpose of our study was to evaluate the relationship between endometrial polyps and obesity, diabetes mellitus (DM) and hypertension (HT).

Materials and methods

202 patients who applied to our gynecology clinic with complaints of infertility, recurrent pregnancy loss and abnormal uterine bleeding, diagnosed to have endometrial polyps by hysteroscopy, were compared with 79 patients without polyps, retrospectively. The relationships between risk factors and presence of a polyp and polyp size were analyzed.

Results

The mean age of cases with endometrial polyps was significantly greater than the controls. The mean body mass index (BMI) of the cases with polyps was also significantly greater than the controls. There was no significant difference between groups with respect to prevalence of DM or HT.

Conclusion

This study suggests that obesity is an independent risk factor in the development of endometrial polyps. Clinicians should be aware in terms of endometrial polyps in the assessment of patients with BMI ≥30. There was no relationship between HT or DM with presence of polyps.

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References

  1. Sherman ME, Manzur MT, Kurman RJ (2002) Benign diseases of the endometrium. In: Kurman RJ (ed) Blaunstein’s pathology of the female genital tract, 3rd edn. Springer, New York, pp 421–466

    Google Scholar 

  2. Goldstein SR, Monteagudo A, Popiolek D, Maybery P, Timor-Tristch I (2002) Evaluation of endometrial polyps. Am J Obstet Gynecol 186:669–674

    Article  PubMed  Google Scholar 

  3. Orovieto R, Bar-Hava I, Dicker D, Bar J, Ben-Rafael Z, Neri A (1999) Endometrial polyps during menopause: characterization and significance. Acta Obstet Gynecol Scand 78:883–886

    Article  Google Scholar 

  4. Schlaen I, Bergeron C, Ferenczy A, Wong P, Naves A (1988) Endometrial polyps: a study of 204 cases. Surg Pathol 1:375–382

    Google Scholar 

  5. Caspi B, Appelman Z, Goldchmit R, Ashkenazi M, Haruvy Y, Hagay Z (2000) The bright edge of the endometrial polyp. Ultrasound Obstet Gynecol 15:327–330

    Article  PubMed  CAS  Google Scholar 

  6. Oguz S, Sargin A, Kelekci S, Ayhan H, Tapisiz OL, Mollamahmutoglu L (2005) The role of hormone replacement therapy in endometrial polyp formation. Maturitas 50:231–236

    Article  PubMed  CAS  Google Scholar 

  7. Reslova T, Tosner J, Resl M, Kugler R, Vavrova I (1999) Endometrial polyps: a clinical study of 245 cases. Arch Gynecol Obstet 262:133–139

    Article  PubMed  CAS  Google Scholar 

  8. DeWaay DJ, Syrop CH, Nygaard IE, Davis WA, Van Voorhis BJ (2002) Natural history of uterine polyps and leiomyomata. Obstet Gynecol 100:3–7

    Article  PubMed  Google Scholar 

  9. Ben-Arie A, Goldchmit C, Laviv Y et al (2004) The malignant potential of endometrial polyps. Eur J Obstet Gynecol Reprod Biol 115:206–210

    Article  PubMed  Google Scholar 

  10. Hinckley MD, Milki AA (2004) 1000 office-based hysteroscopies prior to in vitro fertilization: feasibility and findings. JSLS 8:103–107

    PubMed  PubMed Central  Google Scholar 

  11. Shalev J, Meizner I, Bar-Hava I et al (2000) Predictive value of transvaginal sonography performed before routine diagnostic hysteroscopy for evaluation of infertility. Fertil Steril 73:412–417

    Article  PubMed  CAS  Google Scholar 

  12. Gronlund L, Hertz J, Helm P, Colov NP (1999) Transvaginal sonography and hysteroscopy in evaluation of female infertility, habitual abortion or metrorrhagia. A comparative study. Acta Obstet Gynecol Scand 78:414

    Article  Google Scholar 

  13. Nathani F, Justin Clark T (2006) Uterine polypectomy in management of abnormal uterine bleeding: a systemic review. J Minim Invasive Gynecol 13:260–268

    Article  PubMed  Google Scholar 

  14. National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039–1057

    Article  Google Scholar 

  15. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (1997) The sixth report of the joint national committee on prevention, detection, Evaluation, and treatment of high blood pressure (JNC VI). Arch Intern Med 157:2413–2446

    Article  Google Scholar 

  16. Sharma M, Taylor A, Magos A (2004) Management of endometrial polyps: a clinical review. Rev Gynaecol Pract 4:1–6

    Article  CAS  Google Scholar 

  17. Mittal K, Schwarz L, Goswami S, Demopoulos R (1996) Estrogen and progesterone receptor expression in endometrial polyps. Int J Gynecol Pathol 15:345–348

    Article  PubMed  CAS  Google Scholar 

  18. Reaven GM (1988) Banting lecture 1988: role of human resistance in human disease. Diabetes 37:1595–1607

    Article  PubMed  CAS  Google Scholar 

  19. Rutanen EM (1998) Insulin-like growth factors in endometrial function. Gynecol Endocrinol 12:399–406

    Article  PubMed  CAS  Google Scholar 

  20. Rutanen EM, Stenman S, Blum W, Karkkainen T, Lehtovirta P, Stenman UH (1993) Relationship between carbohydrate metabolism and serum insulin-like growth factor system in postmenopausal women: comparison of endometrial cancer patients with healthy controls. J Clin Endocrinol Metab 77:199–204

    PubMed  CAS  Google Scholar 

  21. Nappi L, Indraccolo U, Sardo ADS et al (2009) Are diabetes, hypertension, and obesity independent risk factors for endometrial polyps? J Minim Invasive Gynecol 16:157–162

    Article  PubMed  Google Scholar 

  22. Dreisler E, Stampe Sorensen S, Lose G (2009) Endometrial polyps and associated factors in Danish women aged 36–74 years. Am J Obstet Gynecol 200:147–153

    PubMed  Google Scholar 

  23. Lass A, Williams G, Abusheikha N, Brinsden P (1999) The effect of endometrial polyps on outcomes of in vitro fertilization cycles. J Assist Reprod Genet 16:410–415

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  24. Önalan R, Önalan G, Tonguç E, Özdener T, Doğan M, Mollamahmutoğlu L (2009) Body mass index is an independent risk factor for the development of endometrial polyps in patients undergoing in vitro fertilization. Fertil Steril 91:1056–1060

    Article  PubMed  Google Scholar 

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Correspondence to Selcuk Selcuk.

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Serhat, E., Cogendez, E., Selcuk, S. et al. Is there a relationship between endometrial polyps and obesity, diabetes mellitus, hypertension?. Arch Gynecol Obstet 290, 937–941 (2014). https://doi.org/10.1007/s00404-014-3279-4

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  • DOI: https://doi.org/10.1007/s00404-014-3279-4

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