Circulating levels of adiponectin, leptin, resistin and visfatin in non-diabetics patients with hidradenitis suppurativa

  • Marcos A. González-LópezEmail author
  • Iosune Vilanova
  • Gonzalo Ocejo-Viñals
  • Rubén Arlegui
  • Iñigo Navarro
  • Sandra Guiral
  • Cristina Mata
  • M. Genma Pérez-Paredes
  • Virginia Portilla
  • Alfonso Corrales
  • M. Carmen González-Vela
  • Miguel A. González-Gay
  • Ricardo Blanco
  • José L. Hernández
Concise Communication


Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with insulin resistance (IR), metabolic syndrome and increased cardiovascular risk. Adipokines are biologically active, pleotropic molecules which have been involved in the development of IR and in the pathogenesis of several chronic inflammatory conditions. The aim of the present study was to analyze serum concentrations of adiponectin, leptin, resistin and visfatin in patients with HS, and investigate their possible associations with IR, HS risk and disease severity. This case–control study enrolled 137 non-diabetic individuals (76 HS-patients and 61 age and sex-matched controls). Serum concentrations of adiponectin, leptin, resistin and visfatin, and the homeostasis model assessment of IR (HOMA-IR) were measured in all the participants. Serum adiponectin concentrations were found to be significantly lower, and leptin, resistin and visfatin levels were significantly higher in HS-patients than in controls. These differences remained significant even after adjusting for age, sex and body mass index, except for leptin. In a multivariate regression analysis, HOMA-IR was inversely correlated with adiponectin and positively associated with resistin levels. Furthermore, serum levels of resistin and visfatin were independently associated with HS risk. However, we found no association between serum levels of adipokines and HS severity. Our results suggest that reduced adiponectin and increased resistin serum levels may be surrogate biomarkers for IR in patients with HS. Moreover, resistin and visfatin might be independent risk factors for the development of HS.


Hidradenitis suppurativa Adiponectin Leptin Resistin Visfatin Insulin resistance 



This study was funded through an unrestricted Grant provided by AbbVie.

Compliance with ethical standards

Conflict of interest

Dr. Marcos A. González López had consultation fees/participation in company sponsored speaker’s bureau from Abbvie. Dr. MA Gonzalez-Gay received grants/research supports from Abbvie, MSD and Roche, and had consultation fees/participation in company sponsored speaker ́s bureau from Pfizer, Lilly, Roche and Sanofi. Dr. R Blanco received grants/research supports from Abbvie, MSD and Roche, and had consultation fees/participation in company sponsored speaker ́s bureau from Abbvie, Pfizer, Roche, Bristol Myers, Janssen and MSD. The rest of the authors have no conflict of interest to declare regarding this paper.

Ethical protocol

The research protocol was approved by the Ethics Committee of Cantabria (Spain). All study procedures were performed in accordance with the ethical principles of the 1964 Declaration of Helsinki and written informed consent was obtained from all the subjects.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Marcos A. González-López
    • 1
    Email author
  • Iosune Vilanova
    • 1
  • Gonzalo Ocejo-Viñals
    • 2
  • Rubén Arlegui
    • 1
  • Iñigo Navarro
    • 1
  • Sandra Guiral
    • 2
  • Cristina Mata
    • 3
  • M. Genma Pérez-Paredes
    • 1
  • Virginia Portilla
    • 4
  • Alfonso Corrales
    • 4
  • M. Carmen González-Vela
    • 5
  • Miguel A. González-Gay
    • 4
  • Ricardo Blanco
    • 4
  • José L. Hernández
    • 6
  1. 1.Division of Dermatology, Hospital Universitario Marqués de ValdecillaUniversity of Cantabria, IDIVALSantanderSpain
  2. 2.Division of Immunology, Hospital Universitario Marqués de ValdecillaUniversity of Cantabria, IDIVALSantanderSpain
  3. 3.Division of RheumatologyHospital ComarcalLaredoSpain
  4. 4.Division of Rheumatology, Hospital Universitario Marqués de ValdecillaUniversity of Cantabria, IDIVALSantanderSpain
  5. 5.Division of Pathology, Hospital Universitario Marqués de ValdecillaUniversity of Cantabria, IDIVALSantanderSpain
  6. 6.Division of Internal Medicine, Hospital Universitario Marqués de ValdecillaUniversity of Cantabria, IDIVALSantanderSpain

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