Archives of Dermatological Research

, Volume 311, Issue 8, pp 637–641 | Cite as

Down-regulation of tissue levels of serine protease inhibitor (vaspin) in psoriasis vulgaris patients: a possible mechanism of narrowband ultraviolet B radiation

  • Khadiga Sayed Sayed
  • Eman Raafat SaidEmail author
  • Faisal Nouredin Mohammed
  • Mira Algorhary
  • Laila Ahmed Rashed
Original Paper


Vaspin is a serine protease inhibitor of the serpin family which has an anti-inflammatory effect. It has an important role in the pathogenesis of some inflammatory diseases such as psoriasis. There are no previous studies comparing the effect of narrowband ultraviolet B (NB-UVB) radiation on tissue vaspin levels in psoriasis. So we aimed in this case–control study to estimate the possible role of vaspin in the pathogenesis of psoriasis, and to evaluate the effect of NB-UVB radiation on tissue vaspin in psoriasis. This study included 21 non-obese patients with moderate psoriasis and 20 non-obese clinically healthy age and sex matched controls. Patients underwent 24 sessions of NB-UVB radiation. A 4 mm punch skin biopsy was taken from all patients before and after treatment and from the controls for estimation of tissue vaspin level by enzyme-linked immunosorbent assay. Vaspin levels was significantly lower in patients before NB-UVB (99.72 pg/mg ± 12.11 pg/mg) compared to controls (257.34 pg/mg ± 28.11 pg/mg) with (P < 0.001). In addition, high significant difference was detected between vaspin levels in patients before (99.72 pg/mg ± 12.39 pg/mg) and after NB-UVB (190.92 pg/mg ± 27.61 pg/mg) with (P < 0.001). In conclusion, improvement of psoriatic plaques by NB-UVB is associated with an upregulation of tissue vaspin levels. Therefore, we suggest that vaspin has an important role in psoriasis pathogenesis.


Psoriasis vulgaris NB-UVB Adipokines Vaspin 




Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the research ethical committee (REC) of Dermatology Department, Faculty of medicine, Cairo University which is organized and operated according to the declaration of Helsinki for human subject researcher 2013.


  1. 1.
    Ataseven A, Kesli R (2016) Novel inflammatory markers in psoriasis vulgaris: vaspin, vascular adhesion protein-1 (VAP-1), and YKL-40. G Ital Dermatol Venereol 151(3):244–250Google Scholar
  2. 2.
    Coban M, Tasli L, Turgut S, Özkan S, Tunç Ata M, Akın F (2016) Association of adipokines, insulin resistance, hypertension and dyslipidemia in patients with psoriasis vulgaris. Ann Dermatol. 28(1):74–79. CrossRefGoogle Scholar
  3. 3.
    Coimbra S, Figueiredo A, Castro E, Rocha-Pereira P, Santos-Silva A (2012) The roles of cells and cytokines in the pathogenesis of psoriasis. Int J Dermatol 51(4):389–398CrossRefGoogle Scholar
  4. 4.
    Diani M, Altomare G, Reali E (2016) T helper cell subsets in clinical manifestations of psoriasis. J Immunol Res 2016:7692024CrossRefGoogle Scholar
  5. 5.
    Fattouh M, El-Din AN, El-Hamd MA (2017) Role of lymphocyte subpopulations in the immunopathogenesis of psoriasis and the effect of narrow band UVB phototherapy on the immunological profile of psoriasis patients. Egypt J Immunol 24(1):105–117Google Scholar
  6. 6.
    Fredriksson T, Petersson U (1978) Severe psoriasis-oral therapy with a new retinoid. Dermatologica 157:238–244CrossRefGoogle Scholar
  7. 7.
    Hida K, Wada J, Eguchi J et al (2005) Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 102(30):10610–10615CrossRefGoogle Scholar
  8. 8.
    Kawashima K, Torii K, Furuhashi T, Saito C, Nishio E, Nishida E, Shintani Y, Morita A (2011) Phototherapy reduces serum resistin levels in psoriasis patients. Photodermatol Photoimmunol Photomed 27(3):152–155. CrossRefGoogle Scholar
  9. 9.
    Lowes MA, Russell CB, Martin DA, Towne JE, Krueger JG (2013) The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol 34:174–181CrossRefGoogle Scholar
  10. 10.
    Menter A, Korman NJ, Elmets CA et al (2010) Guidelines of care for management of psoriasis and psoriatic arthritis: section 5. Guidelines of care for the treatment of psoriasis with phototherapy. J Am Acad Dermatol 62(1):114–135CrossRefGoogle Scholar
  11. 11.
    Nestle FO, Kaplan DH, Barker J (2009) Psoriasis. N Engl J Med 361(5):496–509CrossRefGoogle Scholar
  12. 12.
    Phalitakul S, Okada M, Hara Y et al (2011) Vaspin prevents TNF-alpha-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-kappa B and PKC theta activation in cultured rat vascular smooth muscle cells. Pharmacol Res 64(5):493–500CrossRefGoogle Scholar
  13. 13.
    Priyadarssini M, Divya Priya D, Indhumathi S, Rajappa M, Chandrashekar L, Thappa DM (2016) Immunophenotyping of T cells in the peripheral circulation in psoriasis. Br J Biomed Sci 73(4):174–179CrossRefGoogle Scholar
  14. 14.
    Saalbach A, Vester K, Rall K et al (2012) Vaspin—a link of obesity and psoriasis? Exp Dermatol 21(4):309–312. CrossRefGoogle Scholar
  15. 15.
    Saalbach A, Tremel J, Herbert D et al (2016) Anti-inflammatory action of keratinocyte-derived vaspin: relevance for the pathogenesis of psoriasis. Am J Pathol 186(3):639–651. CrossRefGoogle Scholar
  16. 16.
    Shibata S, Tada Y, Hau C et al (2011) Adiponectin as an anti-inflammatory factor in the pathogenesis of psoriasis: induction of elevated serum adiponectin levels following therapy. Br J Dermatol 164(3):667–670. Google Scholar
  17. 17.
    Takahashi H, Tsuji H, Ishida-Yamamoto A, Iizuka H (2013) Serum level of adiponectin increases and those of leptin and resistin decrease following the treatment of psoriasis. J Dermatol 40(6):475–476. CrossRefGoogle Scholar
  18. 18.
    Wallace AB (1951) The exposure and treatment of burns. Lancet 1(6653):501–504CrossRefGoogle Scholar
  19. 19.
    Zieger K, Weiner J, Krause K, Schwarz M, Kohn M, Stumvoll M, Blüher M, Heiker JT (2018) Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway. Mol Cell Endocrinol 460:181–188. CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Dermatology Department, Faculty of MedicineCairo UniversityCairoEgypt
  2. 2.Dermatology and Venereology DepartmentNational Research CenterGizaEgypt
  3. 3.Biochemistry Department, Faculty of MedicineCairo UniversityCairoEgypt

Personalised recommendations