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Archives of Dermatological Research

, Volume 311, Issue 8, pp 577–588 | Cite as

Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders

  • Samaneh Soleymani
  • Amin Iranpanah
  • Fariba Najafi
  • Tarun Belwal
  • Sudipta Ramola
  • Zahra Abbasabadi
  • Saeideh Momtaz
  • Mohammad Hosein FarzaeiEmail author
Review
  • 202 Downloads

Abstract

The grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications. This paper discusses the favorable effects of RES, GSE and their nanoformulations for dermatological approaches, with specific emphasis on clinical interventions. In this manner, electronic databases including PubMed, Science Direct and Google Scholar were searched. Data were collected from 1980 up to February 2019. The search terms included “Vitis vinifera”, “grape”, “resveratrol”, “skin”, “dermatology”, and “nanoformulation”. To increase the skin permeability of GSE and RES, several innovative nanoformulation such as liposomes, niosomes, solid–lipid nanoparticles, nanostructured lipid carriers, and lipid-core nanocapsule has been evaluated. According to our extensive searches, both RES and GSE have beneficial impacts on skin disorders such as chloasma, acne vulgaris, skin aging, as well as wound and facial redness. More clinical studies with nanoformulation approaches are recommended to achieve conclusive outcomes regarding the efficacy of RES and GSE in the management of skin diseases.

Keywords

Skin diseases Nanoformulations Stilbenes Grape extract Resveratrol 

Abbreviations

CVI

Chronic venous insufficiency

DPPH

2,2-Diphenyl-1-picrylhydrazyl

EGCG

Epigallocatechin gallate

EIM

Ethanol injection-modified method

GS–MS

Gas chromatography–mass spectrometry

GSE

Grape seed extract

HPLC

High-performance liquid chromatography

ICD

Irritant contact dermatitis

LNC

Lipid-core nanocapsule

MPO

Myeloperoxidase

NLC

Nanostructured lipid carriers

PAMAM

Polyamidoamine

PG

Propylene glycol

PUVA

Psoralen with ultraviolet-A

PSR

Psoralen

RES

Resveratrol

QUE

Quercetin

ROS

Reactive oxygen species

SDC

Deoxycholate

SNL

Solid–lipid nanoparticles

TPA

12-O-Tetradecanoylphorbol 13-acetate

UDL

Ultra-deformable liposomes

UV

Ultraviolet

VE

Vitamin E

Notes

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Samaneh Soleymani
    • 1
    • 2
  • Amin Iranpanah
    • 3
  • Fariba Najafi
    • 4
  • Tarun Belwal
    • 5
  • Sudipta Ramola
    • 6
  • Zahra Abbasabadi
    • 7
  • Saeideh Momtaz
    • 8
    • 9
  • Mohammad Hosein Farzaei
    • 7
    Email author
  1. 1.Department of Traditional Pharmacy, School of Persian MedicineTehran University of Medical SciencesTehranIran
  2. 2.PhytoPharmacology Interest Group (PPIG)Universal Scientific Education and Research Network (USERN)TehranIran
  3. 3.Student’s Research Committee, Faculty of PharmacyKermanshah University of Medical SciencesKermanshahIran
  4. 4.Department of Dermatology, Faculty of MedicineKermanshah University of Medical SciencesKermanshahIran
  5. 5.Centre for Biodiversity Conservation and ManagementG. B. Pant National Institute of Himalayan Environment and Sustainable DevelopmentAlmoraIndia
  6. 6.DBS School of Agriculture and Allied SciencesDehradunIndia
  7. 7.Pharmaceutical Sciences Research Center, Health InstituteKermanshah University of Medical SciencesKermanshahIran
  8. 8.Medicinal Plants Research Center, Institute of Medicinal PlantsACECRKarajIran
  9. 9.Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS)Tehran University of Medical SciencesTehranIran

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