Archives of Dermatological Research

, Volume 311, Issue 8, pp 577–588 | Cite as

Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders

  • Samaneh Soleymani
  • Amin Iranpanah
  • Fariba Najafi
  • Tarun Belwal
  • Sudipta Ramola
  • Zahra Abbasabadi
  • Saeideh Momtaz
  • Mohammad Hosein FarzaeiEmail author


The grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications. This paper discusses the favorable effects of RES, GSE and their nanoformulations for dermatological approaches, with specific emphasis on clinical interventions. In this manner, electronic databases including PubMed, Science Direct and Google Scholar were searched. Data were collected from 1980 up to February 2019. The search terms included “Vitis vinifera”, “grape”, “resveratrol”, “skin”, “dermatology”, and “nanoformulation”. To increase the skin permeability of GSE and RES, several innovative nanoformulation such as liposomes, niosomes, solid–lipid nanoparticles, nanostructured lipid carriers, and lipid-core nanocapsule has been evaluated. According to our extensive searches, both RES and GSE have beneficial impacts on skin disorders such as chloasma, acne vulgaris, skin aging, as well as wound and facial redness. More clinical studies with nanoformulation approaches are recommended to achieve conclusive outcomes regarding the efficacy of RES and GSE in the management of skin diseases.


Skin diseases Nanoformulations Stilbenes Grape extract Resveratrol 



Chronic venous insufficiency




Epigallocatechin gallate


Ethanol injection-modified method


Gas chromatography–mass spectrometry


Grape seed extract


High-performance liquid chromatography


Irritant contact dermatitis


Lipid-core nanocapsule




Nanostructured lipid carriers




Propylene glycol


Psoralen with ultraviolet-A








Reactive oxygen species




Solid–lipid nanoparticles


12-O-Tetradecanoylphorbol 13-acetate


Ultra-deformable liposomes




Vitamin E



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Samaneh Soleymani
    • 1
    • 2
  • Amin Iranpanah
    • 3
  • Fariba Najafi
    • 4
  • Tarun Belwal
    • 5
  • Sudipta Ramola
    • 6
  • Zahra Abbasabadi
    • 7
  • Saeideh Momtaz
    • 8
    • 9
  • Mohammad Hosein Farzaei
    • 7
    Email author
  1. 1.Department of Traditional Pharmacy, School of Persian MedicineTehran University of Medical SciencesTehranIran
  2. 2.PhytoPharmacology Interest Group (PPIG)Universal Scientific Education and Research Network (USERN)TehranIran
  3. 3.Student’s Research Committee, Faculty of PharmacyKermanshah University of Medical SciencesKermanshahIran
  4. 4.Department of Dermatology, Faculty of MedicineKermanshah University of Medical SciencesKermanshahIran
  5. 5.Centre for Biodiversity Conservation and ManagementG. B. Pant National Institute of Himalayan Environment and Sustainable DevelopmentAlmoraIndia
  6. 6.DBS School of Agriculture and Allied SciencesDehradunIndia
  7. 7.Pharmaceutical Sciences Research Center, Health InstituteKermanshah University of Medical SciencesKermanshahIran
  8. 8.Medicinal Plants Research Center, Institute of Medicinal PlantsACECRKarajIran
  9. 9.Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS)Tehran University of Medical SciencesTehranIran

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