Association of GA genotype of SNP rs4680 in COMT gene with psoriasis
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Psoriasis is a multigene and multifactorial skin disease with heterogeneous genetic inheritance. Mental disorders participate in the development of psoriasis as predisposing factors; a correlation of dermatological diseases with pathological anxiety and stress was shown. Meanwhile, there are no studies describing molecular mechanisms of the linkages between psycho-emotional disorders and skin diseases. The aim of this study is to find the associations between SNP in genes COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) and CCKBR (rs1805002), and psoriasis. Patients were selected according to the 10th revision of International Classification of Diseases (L-40). The sample size was 88 patients. The size of the control sample (population control) was 365 people. Genotyping was performed using PCR-RFLP and real-time PCR. Statistical analysis was performed using WinPepi software. Identification of complex genotypes was performed by the Monte Carlo method using APSampler 3.6.1 algorithm. Among the studied genes, only GA genotype of COMT gene is significantly associated with psoriasis [χ2 = 19.163 (p = 1.3E−5), F (p) = 1.2E−5, OR 3.47 (CI 99% = 1.61–7.91)]. At the moment, the functional significance of this phenomenon is difficult to explain.
KeywordsPsychodermatology Psoriasis Genes COMT DBH CCKAR CCKBR Polymorphism Genotyping Genetic associations
We would like to thank all patients for their participation in this study. We would also like to thank Ekaterina Gapanovich, Liubov Korobeynikova and Alena Malakhova for helping us provide molecular genetic analysis. This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.
This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
- 2.Afonchikova E, Azimova JE, Fokina NM, Kokaeva ZG, Kochetkova TO, Kondratieva NS, Rudko OI, Tabeeva GR, Klimov EA (2013) Association of MAOA, CCK, COMT, TPH1, SERT, PDE4B with panic disorder in patients from the Moscow population. Febs J 280:343–344Google Scholar
- 9.Favorov AV, Andreewski TV, Sudomoina MA, Favorova OO, Parmigiani G, Ochs MF (2005) A Markov chain Monte Carlo technique for identification of combinations of allelic variants underlying complex diseases in humans. Genetics 171:2113–2121. https://doi.org/10.1534/genetics.105.048090 CrossRefGoogle Scholar
- 15.Iizuka H, Umeda K, Koizumi H, Aoyagi T, Miura Y (1981) Epinephrine-induced cyclic AMP accumulation in the psoriatic epidermis. Acta Derm Venereol 61:391–395Google Scholar
- 16.Ionescu G, Kiehl R (1991) Increased plasma norepinephrine in psoriasis. Acta Derm Venereol 71:169–170Google Scholar
- 17.Kato T, Wang ZW, Zoega T, Crowe RR (1996) Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder. Am J Med Genet 67:401–405. https://doi.org/10.1002/(SICI)1096-8628(19960726)67:4%3C401::AID-AJMG14%3E3.0.CO;2-N CrossRefGoogle Scholar
- 29.Wong JW, Koo JY (2013) Psychopharmacological therapies in dermatology. Dermatol Online J 19:18169Google Scholar