Archives of Dermatological Research

, Volume 311, Issue 4, pp 309–315 | Cite as

Association of GA genotype of SNP rs4680 in COMT gene with psoriasis

  • Vladimir Sobolev
  • Luiza Sakaniya
  • Artemii Tretiakov
  • Zarema Kokaeva
  • Elena Naumova
  • Olga Rudko
  • Anna Soboleva
  • Ivan Danilin
  • Irina Korsunskaya
  • Eugene KlimovEmail author
Original Paper


Psoriasis is a multigene and multifactorial skin disease with heterogeneous genetic inheritance. Mental disorders participate in the development of psoriasis as predisposing factors; a correlation of dermatological diseases with pathological anxiety and stress was shown. Meanwhile, there are no studies describing molecular mechanisms of the linkages between psycho-emotional disorders and skin diseases. The aim of this study is to find the associations between SNP in genes COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) and CCKBR (rs1805002), and psoriasis. Patients were selected according to the 10th revision of International Classification of Diseases (L-40). The sample size was 88 patients. The size of the control sample (population control) was 365 people. Genotyping was performed using PCR-RFLP and real-time PCR. Statistical analysis was performed using WinPepi software. Identification of complex genotypes was performed by the Monte Carlo method using APSampler 3.6.1 algorithm. Among the studied genes, only GA genotype of COMT gene is significantly associated with psoriasis [χ2 = 19.163 (p = 1.3E−5), F (p) = 1.2E−5, OR 3.47 (CI 99% = 1.61–7.91)]. At the moment, the functional significance of this phenomenon is difficult to explain.


Psychodermatology Psoriasis Genes COMT DBH CCKAR CCKBR Polymorphism Genotyping Genetic associations 



We would like to thank all patients for their participation in this study. We would also like to thank Ekaterina Gapanovich, Liubov Korobeynikova and Alena Malakhova for helping us provide molecular genetic analysis. This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.


This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Vladimir Sobolev
    • 1
    • 2
    • 3
  • Luiza Sakaniya
    • 1
  • Artemii Tretiakov
    • 4
  • Zarema Kokaeva
    • 4
  • Elena Naumova
    • 4
  • Olga Rudko
    • 4
  • Anna Soboleva
    • 1
  • Ivan Danilin
    • 5
  • Irina Korsunskaya
    • 1
  • Eugene Klimov
    • 3
    • 4
    • 6
    Email author
  1. 1.Centre of Theoretical Problems of Physico-Chemical PharmacologyRussian Academy of SciencesMoscowRussia
  2. 2.I.I. Mechnikov Research Institute for Vaccines and SeraMoscowRussia
  3. 3.University Diagnostic Laboratory, LLCMoscowRussia
  4. 4.Faculty of Biology, Lomonosov Moscow State UniversityMoscowRussia
  5. 5.Peoples’ Friendship University of RussiaMoscowRussia
  6. 6.Center of Experimental Embryology and Reproductive BiotechnologiesMoscowRussia

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