Archives of Dermatological Research

, Volume 311, Issue 1, pp 19–27 | Cite as

Mortality and risk factors among Israeli bullous pemphigoid patients

  • Mati RozenblatEmail author
  • Awad Halaj
  • Tal Rozenblat
  • Shani Fisher
  • Mohammad Sah
  • Roni P. Dodiuk-Gad
  • Michael Ziv
Original Paper


There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients without BP (n = 261) who were treated in our clinic were selected and compared to BP patients (n = 87). Mean survival period of the BP group was 4.1 years (95% CI: 3.3–4.8 years) and 5.9 years among the non-BP group (95% CI: 5.6–6.3 years). The 1-year mortality rate was 24.1% for the BP group and 6.5% for the control group. In multivariate analysis, age above 80 was a significant risk factor for mortality [HR 3.22 (95% CI, 1.15–8.96), p = 0.03], while statins intake had a protective role [HR 0.36 (95% CI, 0.15–0.88), p = 0.03]. In univariant analysis, dementia [HR 2.44 (95% CI, 1.02–5.99), p = 0.04] was a risk factor. In conclusion, BP patients’ mortality is correlated to increasing age at diagnosis, dementia, and statins use. Statins’ protective role is newly discussed in the literature.


Bullous pemphigoid Pemphigoid Mortality Prognosis 



No funding was received for this research.

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no conflict of interests.

Research involving human participants and/or animals

Reviewed and approved by Emek Medical Center IRB (institutional review board), approval number: 151-15.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of DermatologyEmek Medical CenterAfulaIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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