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Archives of Dermatological Research

, Volume 310, Issue 9, pp 711–728 | Cite as

Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis

  • Qiong Yin
  • Liang-Cai Wu
  • Lu Zheng
  • Ming-Yu Han
  • Li-Ya Hu
  • Pian-Pian Zhao
  • Wei-Yang Bai
  • Xiao-Wei Zhu
  • Jiang-Wei Xia
  • Xiao-Bo Wang
  • Xing-Wei Zhang
  • Hou-Feng Zheng
Original Paper
  • 54 Downloads

Abstract

Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1 (9288 patients and 24,040 controls), TYK2 (4928 patients and 11,536 controls), IL-10 (3623 patients and 4907 controls) polymorphisms and systemic lupus erythematosus (SLE) in a comprehensive way. We found that IFIH1 rs1990760_T allele was associated with risk of SLE in overall population under three models (allelic: P = 2.56 × 10−11, OR 1.135, 95% CI 1.094–1.179, dominant: P = 1.8 × 10−8, OR 1.203, 95% CI 1.128–1.284, recessive: P = 2.6 × 10−7, OR 1.163, 95% CI 1.098–1.231). A strong association had been observed between TYK2 polymorphism rs2304256_C allele and SLE in Europeans (P = 5.82 × 10−5, OR 1.434, 95% CI 1.203–1.710). When coming to overall population, TYK2 rs2304256_C showed a significant association with SLE under recessive model (P = 8.05 × 10−3, OR 1.314, 95% CI 1.074–1.608). However, the other two SNPs (rs12720270, rs280519) of TYK2 were not significant. The results also indicated an association between IL-10 rs1800896_G allele and SLE in Asians under recessive model (P = 4.65 × 10−3, OR 2.623, 95% CI 1.346–5.115), while, IL-10 rs1800896_G had a trend of association with SLE in European population in dominant model (P = 1.21 × 10−2, OR 1.375, 95% CI 1.072–1.764). In addition, we found IL-10 rs1800896 GG homozygote might be associated with increased susceptibility to SLE (GG vs AA, P = 4.65 × 10−3, OR 1.539, 95% CI 1.142–2.072). We concluded that IFIH1 rs1990760_T and TYK2 rs2304256_C alleles were significantly associated with SLE, and IL-10 rs1800896 GG homozygote might have an enhancement effect on SLE risk.

Keywords

IFIH1 TYK2 IL-10 Meta-analysis Systemic lupus erythematosus 

Notes

Acknowledgements

This study was supported by the National Natural Science Foundation of China (81501145, 81871831), the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China (LR17H070001), the State Key Development Program for Basic Research of China (973 Program, 2014CB541701), the “Thousand Talents” Program, the HZNUARI-Pilot Research Grant and Guangdong Provincial Science and Technology Plan project (2014A020212434). The funding agencies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank the peer reviewers for their thorough and helpful review of this manuscript.

Compliance with ethical standards

Conflict of interest

The authors have no competing interests that might be perceived to influence the results and/or discussion reported in this paper. This study re-analyzed the previous published data, therefore, this study did not involve origin human participants.

Supplementary material

403_2018_1858_MOESM1_ESM.pdf (3.7 mb)
Supplementary material 1 (PDF 3775 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Qiong Yin
    • 1
    • 2
  • Liang-Cai Wu
    • 3
  • Lu Zheng
    • 4
  • Ming-Yu Han
    • 5
  • Li-Ya Hu
    • 2
  • Pian-Pian Zhao
    • 1
  • Wei-Yang Bai
    • 1
  • Xiao-Wei Zhu
    • 1
  • Jiang-Wei Xia
    • 1
  • Xiao-Bo Wang
    • 2
  • Xing-Wei Zhang
    • 2
  • Hou-Feng Zheng
    • 1
    • 2
  1. 1.Diseases & Population (DaP) Geninfo Lab, School of Life SciencesWestlake University and Westlake Institute for Advanced StudyHangzhouChina
  2. 2.Institute of Aging Research and the Affiliated Hospital, School of MedicineHangzhou Normal UniversityHangzhouChina
  3. 3.Department of Dermatology, The 6th Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  4. 4.Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina
  5. 5.School of Biomolecular and Biomedical ScienceUniversity College DublinDublinIreland

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