Archives of Orthopaedic and Trauma Surgery

, Volume 139, Issue 5, pp 623–627 | Cite as

The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee

  • Hans Roland DürrEmail author
  • Carl Ferdinand Capellen
  • Alexander Klein
  • Andrea Baur-Melnyk
  • Christof Birkenmaier
  • Volkmar Jansson
  • Reinhold Tiling
Orthopaedic Surgery



Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. The aim of this study was to compare local recurrence (LR) rates after surgical synovectomy with and without adjuvant RSO.

Materials and methods

From 1996 to 2014, 37 surgical interventions were performed in 32 patients with diffuse pigmented villonodular synovitis of the knee. All patients underwent open synovectomy. Adjuvant radiosynoviorthesis (RSO) was applied in 26 cases, the control group consists of 11 cases without RSO.


9 (24%) lesions recurred within a median of 19 months after surgery. Of those 9 recurrences, 3 (17%) were seen in primary disease, 6 (32%) in already recurring cases (n.s.). In 26 RSO treated patients 6 (23%) recurred, in 11 patients of the control group, 3 (27%) recurred (n.s.).


RSO is effective in PVS as also shown in some smaller reports in the literature. But surgery is still the mainstay of therapy. RSO is not a method of compensating for an insufficient surgical approach, but it may reduce the high rate of LR in patients with large and even recurrent diffuse forms of the disease.


Synovitis Pigmented villonodular Giant cell tumor of tendon sheath Synovectomy Neoplasm recurrence Local Radiosynoviorthesis 



All authors have no financial and personal relationships with other people or organizations that could inappropriately influence (bias) this work. This study was not supported by any grants or external funding.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This study was approved by the ethics committee of the Medical Faculty, University of Munich.

Informed consent

Written consent was obtained from all patients included in this study.

Data availability

The datasets used and/or analysed during the current study are available from the corresponding author upon reasonable request.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Hans Roland Dürr
    • 1
    Email author
  • Carl Ferdinand Capellen
    • 1
  • Alexander Klein
    • 1
  • Andrea Baur-Melnyk
    • 3
  • Christof Birkenmaier
    • 1
  • Volkmar Jansson
    • 1
  • Reinhold Tiling
    • 2
  1. 1.Musculoskeletal Oncology, Department of Orthopaedics, Physical Medicine and RehabilitationUniversity Hospital, LMU MunichMunichGermany
  2. 2.Department of Nuclear MedicineUniversity Hospital, LMU MunichMunichGermany
  3. 3.Institute of RadiologyUniversity Hospital, LMU MunichMunichGermany

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