Release mechanism of lipid nanoparticles immobilized within alginate beads influenced by nanoparticle size and alginate concentration

  • Rui Sun
  • Qiang XiaEmail author
Original Contribution


The combination of hydrogels and lipid carriers has been widely used in the encapsulation of oil-soluble active ingredients. The objective of the present work was to understand the release mechanism of lipid nanoparticles (LNP) immobilized within alginate hydrogel beads. To evaluate the amount of LNP released from alginate beads, a simple method derived from dynamic light scattering was established and applied in the dissolution study effectively. The presence of LNP-mediated release was confirmed in the dissolution study. The dissolution study in simulated gastric fluids, involving diffusion-controlled release model, indicated that the LNP-mediated release was susceptible to the size of LNP and alginate concentration. The release study in simulated intestinal fluids, involving swelling-controlled release model, showed that the alginate concentration had a decisive effect on the release. This study will be helpful for the design of a new delivery system, which combines hydrogels and lipid carriers.

Graphical abstract

Diffusion-controlled release and swelling-controlled release of lipid nanoparticles immobilized within alginate beads.


Release mechanism Lipid nanoparticles Alginate beads Dynamic light scattering Dissolution study 


Funding information

This investigation was supported by Science and Technology Achievements Transformation Project (grant no. BA2014096) of Jiangsu Province of China.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

396_2019_4538_MOESM1_ESM.pdf (551 kb)
ESM 1 (PDF 550 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Biological Science and Medical Engineering, State Key Laboratory of BioelectronicsSoutheast UniversityNanjingChina
  2. 2.National Demonstration Center for Experimental Biomedical Engineering EducationSoutheast UniversityNanjingChina
  3. 3.Collaborative Innovation Center of Suzhou Nano Science and TechnologySuzhouChina

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