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Colloid and Polymer Science

, Volume 297, Issue 5, pp 763–769 | Cite as

Biodegradable poly(N-isopropylacrylamide-co-N-maleylgelatin) hydrogels with adjustable swelling behavior

  • Feifei Xin
  • Meiyu Sui
  • Xisheng Liu
  • Cong Zhao
  • Yueqin YuEmail author
Original Contribution
  • 42 Downloads

Abstract

This study describes the detailed investigation on dynamic swelling of biodegradable network system poly(N-isopropylacrylamide-co-N-maleylgelatin) P(NIPAAm-co-N-MAGEL) prepared by N-isopropylacrylamide (NIPAAm) and N-maleylgelatin (MAGEL) with N,N′-methylene bis(acrylamide) (BIS) as a cross-linking agent. Effects of MAGEL content on the swelling behavior were investigated. The results showed that the swelling kinetics were dependent on the content of MAGEL and the maximum swelling rate was observed at 30% content of MAGEL. The swelling process follows second-order kinetics, and the mechanism of water transport is pseudo-Fickian type of diffusion. Swelling kinetics under different concentrations of NaCl was also studied. The swelling rate decreased with increasing the concentration of NaCl.

Graphical abstract

The swelling rate of P(NIPAAm-co-N-MAGEL) hydrogel can be tuned by MAGEL content and NaCl concentration.

Keywords

Hydrogel Swelling kinetics Adjustable Second-order Pseudo-Fickian diffusion 

Notes

Funding information

This research was supported by the National Natural Science Foundation of China (No. 20876081) and the Science Foundation of Shandong Province (ZR2012BM015).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

396_2019_4498_MOESM1_ESM.docx (485 kb)
ESM 1 (DOCX 485 kb)

References

  1. 1.
    Liu H, Li MX, Ouyang C, Lu TJ, Li F, Xu F (2018) Biofriendly, stretrable, and reusable hydrogel electronics as wearable force sensors. Small 14:1801711–1801719CrossRefGoogle Scholar
  2. 2.
    Buchtová N, D’Orrlando A, Judeinstein P, Chauvet O, Weiss P, Le Bideau J (2018) Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering. Carbohydr Polym 22:401–408Google Scholar
  3. 3.
    Hasany M, Thakur A, Taebnia N, Kadumudi FB, Shahbazi MA, Pierchala MK, Mohanty S, Orive G, Andresen TL, Foldager CB, Yaghmaei S, Arpanaei A, Gaharwar AK, Mehrali M, Dolatshahi-Pirouz A (2018) Combinatorial screening of nanoclay-reinforced hydrogels: a glimpse of the “holy grail” in orthopedic stem cell therapy? ACS Appl Mater Interfaces 10:34924–34941CrossRefGoogle Scholar
  4. 4.
    Culver HR, Clegg JR, Peppas NA (2017) Analyte-responsive hydrogels: intelligent materials for biosensing and drug delivery. Acc Chem Res 50:170–178CrossRefGoogle Scholar
  5. 5.
    Winnik FM (1990) Fluorescence studies of aqueous solutions of poly(N-isopropylacrylamide) below and above their LCST. Macromolecules 23:233–242CrossRefGoogle Scholar
  6. 6.
    Xia LW, Xie R, Ju XJ, Wang W, Chen QM, Chu LY (2013) Nano-structured smart hydrogels with rapid response and high elasticity. Nat Commun 4:2226–2236CrossRefGoogle Scholar
  7. 7.
    Halperin A, Kroeger M, Winnik FM (2015) Poly(N-isopropylacrylamide) phase diagrams: fifty years of research. Angew Chem Int Ed 54:15342–15367CrossRefGoogle Scholar
  8. 8.
    Ashraf S, Park HK, Park H, Lee SH (2016) Snapshot of phase transition in thermoresponsive hydrogel PNIPAM: role in drug delivery and tissue engineering. Macromol Res 24:297–304CrossRefGoogle Scholar
  9. 9.
    Abdul Haq M, Su YL, Wang DJ (2017) Mechanical properties of PNIPAM based hydrogels: a review. Mater Sci Eng C 70:842–855CrossRefGoogle Scholar
  10. 10.
    Hasuike E, Akimoto AM, Kuroda R, Matsukawa K, Hiruta Y, Kanazawa H, Yoshida R (2017) Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel. Chem Commun 53:3142–3144CrossRefGoogle Scholar
  11. 11.
    Bae YH, Okano T, Kim SW (1990) Temperature dependence of swelling of crosslinked poly(N,N’-alkyl substituted acrylamides) in water. J Polym Sci B Polym Phys 28:923–936CrossRefGoogle Scholar
  12. 12.
    Lutz JF, Akdemir O, Hoth A (2006) Point by point comparison of two thermosensitive polymers exhibiting a similar LCST: is the age of poly(NIPAM) over? J Am Chem Soc 128:13046–13047CrossRefGoogle Scholar
  13. 13.
    Rzaev ZM, Dincer S, Pişkin E (2007) Functional copolymers of N-isopropylacrylamide for bioengineering applications. Prog Polym Sci 32:534–595CrossRefGoogle Scholar
  14. 14.
    Yu YQ, Li Z, Tian H (2007) Synthesis and characterization of thermoresponsive hydrogels cross-linked with acryloyloxyethylaminopolysuccinimide. Colloid Polym Sci 285:1553–1560CrossRefGoogle Scholar
  15. 15.
    Yu YQ, Xu Y, Ning H (2008) Swelling behaviors of thermoresponsive hydrogels cross-linked with acryloyloxyethylaminopolysuccinimide. Colloid Polym Sci 286:1165–1171CrossRefGoogle Scholar
  16. 16.
    Yu YQ, Li Y, Liu L (2011) Synthesis and characterization of pH- and thermoresponsive poly (N-isopropylacrylamide-co-itaconic acid) hydrogels crosslinked with N-maleyl chitosan. J Polym Res 18:283–291CrossRefGoogle Scholar
  17. 17.
    Zheng Y, Wang B, Liu M, Jiang K, Wang L, Yu YQ (2015) Synthesis and characterization of biodegradable thermoresponsive N-maleylgelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with bis-acrylamide for control release. Colloid Polym Sci 293:1615–1621CrossRefGoogle Scholar
  18. 18.
    Yu YQ, Lu QL, Yuan SC, Zhang RL, Wu ZM (2017) Properties of thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel with ultrahigh mechanical strength and self-recovery. J Polym Res 24:190–197CrossRefGoogle Scholar
  19. 19.
    Xin FF, Lu QL, Liu BX, Yuan SC, Zhang RL, Wu YM, Yu YQ (2018) Metal-ion-mediated hydrogels with thermo-responsiveness for smart windows. Eur Polym J 99:65–71CrossRefGoogle Scholar
  20. 20.
    Dong YX, Sigen A, Rodrigues M, Li XL, Kwon SH, Kosaric N, Khong S, Gao YS, Wang WX, Gurtner GC (2017) Injectable and tunable gelatin hydrogels enhance stem cell retention and improve cutaneous wound healing. Adv Funct Mater 27:1606619–1606630CrossRefGoogle Scholar
  21. 21.
    Salzmann P, Perrotta A, Coclite AM (2018) Different response kinetics to temperature and water vapor of acrylamide polymers obtained by initiated chemical vapor deposition. ACS Appl Mater Interfaces 10:6636–6645CrossRefGoogle Scholar
  22. 22.
    Ogieglo W, Stenbock-Fermor A, Juraschek TM, Bogdanova Y, Benes N, Tsarkova LA (2018) Synergic swelling of interactive network support and block copolymer films during solvent vapor annealing. Langmuir 34:9950–9960CrossRefGoogle Scholar
  23. 23.
    Lee E, Kim D, Yang SY, Ohd JW, Yoon J (2017) Photo-crosslinkable comb-type copolymers bearing a benzophenone moiety for the enhanced swelling kinetics of hydrogels. Polym Chem 8:6786–6794CrossRefGoogle Scholar
  24. 24.
    Bahtz J, Gunes DZ, Syrbe A, Mosca N, Fischer P, Windhab EJ (2016) Quantification of spontaneous W/O emulsification and its impact on the swelling kinetics of multiple W/O/W emulsions. Langmuir 32:5787–5795CrossRefGoogle Scholar
  25. 25.
    Zırıh T, Orakdogen N (2016) Evaluation of pH/temperature double responsivity of copolymerized methacrylate-based networks: solvent diffusion analysis with adjustable swelling kinetics. Eur Polym J 75:371–387CrossRefGoogle Scholar
  26. 26.
    Ostrowska-Czubenko J, Gierszewska M, Pieróg M (2015) pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling. J Polym Res 22:153–164CrossRefGoogle Scholar
  27. 27.
    Zhang HJ, Pang XJ, Qi Y (2015) pH-sensitive graphene oxide/sodium alginate/ polyacrylamide nanocomposite semi-IPN hydrogel with improved mechanical strength. RSC Adv 5:89083–89091CrossRefGoogle Scholar
  28. 28.
    Krishna KA, Vishalakshi B (2017) Gellan gum-based novel composite hydrogel: evaluation as adsorbent for cationic dyes. J Appl Polym Sci 134:45527–45535CrossRefGoogle Scholar
  29. 29.
    Quintana JR, Valderruten NE, Katime I (1999) Synthesis and swelling kinetics of poly(dimethylaminoethyl acrylate methyl chloride quaternary-co-itaconic acid) hydrogels. Langmuir 15:4728–4730CrossRefGoogle Scholar
  30. 30.
    Francis S, Kumar M, Varshney L (2004) Radiation synthesis of superabsorbent poly(acrylic acid)-carrageenan hydrogels. Radiat Phys Chem 69:481–486CrossRefGoogle Scholar
  31. 31.
    Hermans JJ (1953) Flow properties of disperse systems. Wiley-Interscience, New YorkGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Feifei Xin
    • 1
  • Meiyu Sui
    • 1
  • Xisheng Liu
    • 1
  • Cong Zhao
    • 1
  • Yueqin Yu
    • 1
    Email author
  1. 1.State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdaoPeople’s Republic of China

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