Colloid and Polymer Science

, Volume 297, Issue 5, pp 763–769 | Cite as

Biodegradable poly(N-isopropylacrylamide-co-N-maleylgelatin) hydrogels with adjustable swelling behavior

  • Feifei Xin
  • Meiyu Sui
  • Xisheng Liu
  • Cong Zhao
  • Yueqin YuEmail author
Original Contribution


This study describes the detailed investigation on dynamic swelling of biodegradable network system poly(N-isopropylacrylamide-co-N-maleylgelatin) P(NIPAAm-co-N-MAGEL) prepared by N-isopropylacrylamide (NIPAAm) and N-maleylgelatin (MAGEL) with N,N′-methylene bis(acrylamide) (BIS) as a cross-linking agent. Effects of MAGEL content on the swelling behavior were investigated. The results showed that the swelling kinetics were dependent on the content of MAGEL and the maximum swelling rate was observed at 30% content of MAGEL. The swelling process follows second-order kinetics, and the mechanism of water transport is pseudo-Fickian type of diffusion. Swelling kinetics under different concentrations of NaCl was also studied. The swelling rate decreased with increasing the concentration of NaCl.

Graphical abstract

The swelling rate of P(NIPAAm-co-N-MAGEL) hydrogel can be tuned by MAGEL content and NaCl concentration.


Hydrogel Swelling kinetics Adjustable Second-order Pseudo-Fickian diffusion 


Funding information

This research was supported by the National Natural Science Foundation of China (No. 20876081) and the Science Foundation of Shandong Province (ZR2012BM015).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

396_2019_4498_MOESM1_ESM.docx (485 kb)
ESM 1 (DOCX 485 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Feifei Xin
    • 1
  • Meiyu Sui
    • 1
  • Xisheng Liu
    • 1
  • Cong Zhao
    • 1
  • Yueqin Yu
    • 1
    Email author
  1. 1.State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdaoPeople’s Republic of China

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