Preparation of multiresponsive nanogels and their controlled release properties
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Multiresponsive nanogels, which are sensitive to pH/temperature/glucose concentration have been synthesized by using N,N-diethylacrylamide (DEA) and 4-vinylphenylboronic acid (VPBA) as reaction monomer. The influence of the VPBA/DEA feeding ratio and emulsifier concentration on the as-prepared nanogel’s size and size distribution was investigated. Under the optimized condition, the diameter of the as-prepared P(DEA-co-VPBA) nanogel was 186.9 nm with excellent monodispersity (PDI 0.005); its entrapment efficiency reached 88.67% and loading efficiency of insulin reached 17.73%. The release rate of insulin loaded in the P(DEA-co-VPBA) nanogels could be adjusted by glucose concentration, which could adjust and control the blood glucose concentration in a stable concentration range intelligently. The multiresponsive nanogels could potentially be used in the fields of self-regulated drug delivery systems, real-time optical diagnosis, and monitoring of the response to treatment.
KeywordsN,N-Diethylacrylamide (DEA) Vinylphenylboronic acid (VPBA) Nanogels Glucose Drug release
This work was financially supported by the National Natural Science Foundation of China (51473032 and 51503034).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interests.
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