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Colloid and Polymer Science

, Volume 297, Issue 1, pp 85–93 | Cite as

Incorporation of gold nanoparticles into the bilayer of polydiacetylene unilamellar vesicles

  • Andrew Tobias
  • William Rooke
  • Timothy W. HanksEmail author
Original Contribution
  • 51 Downloads

Abstract

Gold nanoparticles made with three different alkanethiol surface passivating agents were loaded into the hydrophobic bilayers of polydiacetylene liposomes. The physical and optical properties of the vesicles were compared to each other and a nanoparticle-free control. Small gold nanoparticles were utilized to minimize the plasmon absorption and thereby minimize the effects of energy transfer processes on the optical behavior of the polydiacetylene moiety. The size and structure of the liposomes were examined with dynamic light scattering and electron microscopy, while the stability of the bilayer was investigated through differential scanning calorimetry. Optical spectroscopy was used to monitor the photopolymerization of the vesicles as well as the stress-induced polydiacetylene blue to red transition. Specifically, changes to the absorption frequency, fluorescence frequency, and the fluorescence intensity were monitored. This system can serve as a model system for the optimization of liposomes containing nanoparticles with specialized optical, magnetic, or chemical functionality.

Keywords

Polydiacetylene Liposome Gold nanoparticle Fluorescence Electron microscopy 

Notes

Acknowledgments

The authors gratefully acknowledge the assistance of Steven Myles, Michelin Americas Research Center, for assistance with TEM data collection.

Funding

This work was supported in part by the National Science Foundation EPSCoR Program under NSF Award # OIA-1655740.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Disclaimer

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect those of the National Science Foundation.

Supplementary material

396_2018_4441_MOESM1_ESM.pdf (1.1 mb)
ESM 1 (PDF 1133 kb)

References

  1. 1.
    Bangham AD, Standish MM, Watkins JC (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 13:238–252 IN27CrossRefGoogle Scholar
  2. 2.
    Lasic DD (1995) Applications of Liposomes. In: R. Lipowsky and E. Sackmann, (eds) Handbook of Biological Physics, Elsevier ScienceGoogle Scholar
  3. 3.
    Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8:102.  https://doi.org/10.1186/1556-276X-8-102 CrossRefGoogle Scholar
  4. 4.
    Wen JT, Roper JM, Tsutsui H (2018) Polydiacetylene supramolecules: synthesis, characterization, and emerging applications. Ind Eng Chem Res 57:9037–9053CrossRefGoogle Scholar
  5. 5.
    Pattni BS, Chupin VV, Torchilin VP (2015) New developments in liposomal drug delivery. Chem Rev 115:10938–10966CrossRefGoogle Scholar
  6. 6.
    Malam B, Loizidou M, Seifalian AM (2009) Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci 30:592–599CrossRefGoogle Scholar
  7. 7.
    Grimaldi N, Andrade F, Segovia N, Ferrer-Tasies L, Sala S, Veciana J, Ventosa N (2016) Lipid-based nanovesicles for nanomedicine. Chem Soc Rev 45:6520–6545CrossRefGoogle Scholar
  8. 8.
    Maruyama K (2011) Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects. Adv Drug Deliv Rev 63:161–169CrossRefGoogle Scholar
  9. 9.
    Perche F, Torchilin VP (2013) Recent trends in multifunctional liposomal nanocarriers for enhanced yumor targeting. J Drug Deliv Article ID 705265.  https://doi.org/10.1155/2013/705265
  10. 10.
    Petersen AL, Hansen AE, Gabizon A, Andresen TL (2012) Liposome imaging agents in personalized medicine. Adv Drug Deliv Rev 64:1417–1435CrossRefGoogle Scholar
  11. 11.
    Patel DM, Jani RH, Patel CM (2011) Ufasomes: a vesicular drug delivery. System Rev Pharm 2:72–78CrossRefGoogle Scholar
  12. 12.
    Morigaki K, Walde P (2007) Fatty acid vesicles. Cur Opinion Colloid Inter Sci 12:75–80CrossRefGoogle Scholar
  13. 13.
    Baughman RH, Yee KC (1978) Solid-state polymerization of linear and cyclic acetylenes. J Poly Sci D:Macromol Rev 13:219–239Google Scholar
  14. 14.
    Bloor D, Chance RR (eds) (1985) Polydiacetylenes: synthesis, structure and electronic properties. Martinus Nijhoff, BostonGoogle Scholar
  15. 15.
    Carpick RW, Sasaki DY, Eriksson MA, Burns AR (2004) Polydiacetylene films: a review of recent investigations into chromogenic transitions and Nanomechanical properties. J Phys Condens Matter 16:R679–R697CrossRefGoogle Scholar
  16. 16.
    Giorgetti E, Muniz-Miranda M, Margheri G, Giusti A, Sottini S, Alloisio M, Cuniberti C, Dellepiane G (2006) UV polymerization of self-assembled monolayers of a novel diacetylene on silver: a spectroscopic analysis by surface plasmon resonance and surface enhanced Raman scattering. Langmuir 22:1129–1134CrossRefGoogle Scholar
  17. 17.
    Okada S, Peng S, Spevak W, Charych D (1998) Color and chromism of polydiacetylene vesicles. Acc Chem Res 31:229CrossRefGoogle Scholar
  18. 18.
    Bloor D (2001) Dissolution and spectroscopic properties of the polydiacetylene poly(10,12-docosadiyne-1,12-diol-bisethylurethane). Macromol Chem Phys 202:1410CrossRefGoogle Scholar
  19. 19.
    Charych DH, Nagy JO, Spevak W, Bednarskik MD (1993) Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly. Science 261:585–588CrossRefGoogle Scholar
  20. 20.
    Wen JT, Roper JM, Tsutsui H (2018) Polydiacetylene supramolecules: synthesis, characterization, and emerging applications. Ind Eng Chem Res 57:9037–9053CrossRefGoogle Scholar
  21. 21.
    Jelinek R, Kolusheva S (2007) Biomolecular sensing with colorimetric vesicles. Top Curr Chem 277:155–180CrossRefGoogle Scholar
  22. 22.
    Mazura F, Ballyc M, Städlerd B, Chandrawati R (2017) Liposomes and lipid bilayers in biosensors. Adv Colloid Interf Sci 249:88–99CrossRefGoogle Scholar
  23. 23.
    Scindia Y, Silbert L, Volinsky R, Kolusheva S, Jelinek R (2007) Colorimetric detection and finger printing of bacteria by glass-supported lipid/polydiacetylene films. Langmuir 23:4682–4687CrossRefGoogle Scholar
  24. 24.
    Soenen SJ, Velde GC, Ketkar-Atre A, Himmelreich U, De Cuyper M (2011) Magnetoliposomes as magnetic resonance imaging contrast agents. WIREs Nanomed Nanobiotech 3:197–211CrossRefGoogle Scholar
  25. 25.
    Sun C, JSH L, Zhang M (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60:252CrossRefGoogle Scholar
  26. 26.
    Wahajuddin AS (2012) Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomedicine 2:3445–3471CrossRefGoogle Scholar
  27. 27.
    Reimhult E (2015) Nanoparticle-triggered release from lipid membrane vesicles. New Biotechnol 32:665–672CrossRefGoogle Scholar
  28. 28.
    Nakao R, Matuo Y, Mishima F, Taguchi T, Maenosono S, Mishijima S (2009) Development of magnetic separation system of magnetoliposomes. Physica C 469:1840–1844CrossRefGoogle Scholar
  29. 29.
    Shim W-B, Lee C-W, Kim M-G, Chung D-H (2014) An antibody–magnetic nanoparticle conjugate- based selective filtration method for the rapid colorimetric detection of Listeria monocytogenes. Anal Methods 6:9129–9135CrossRefGoogle Scholar
  30. 30.
    Paasonen L, Laaksonen T, Johans C, Yliperttula M, Kontturi K, Urtti A (2007) Gold nanoparticles enable selective light-induced contents release from liposomes. J Control Release 122:86–93CrossRefGoogle Scholar
  31. 31.
    Thamphiwatana S, Fu V, Zhu J, Lu D, Gao W, Zhang L (2013) Nanoparticle-stabilized liposomes for pH-responsive gastric drug delivery. Langmuir 29:12228–12233CrossRefGoogle Scholar
  32. 32.
    Zheng W, Liu Y, West A, Schuler EE, Yehl K, Dyer RB, Kindt JT, Salaita K (2014) Quantum dots encapsulated within phospholipid membranes: phase-dependent structure, photostability, and site-selective functionalization. J Am Chem Soc 136:1992–1999CrossRefGoogle Scholar
  33. 33.
    Zhou J, Wang Q-X, Zhang C-Y (2013) Liposome−quantum dot complexes enable multiplexed detection of attomolar DNAs without target amplification. J Am Chem Soc 135:2056–2059CrossRefGoogle Scholar
  34. 34.
    Chu M, Zhuo J, Xu J, Sheng Q, Hou S, Wang R (2010) Liposome-coated quantum dots targeting the sentinel lymph node. J Nanopart Res 12:187–197CrossRefGoogle Scholar
  35. 35.
    de Smet M, Heijman E, Langereis S, Langereis S, Hijnen NM, Grull H (2011) Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: an in vivo proof-of-concept study. J Control Release 150:102–110CrossRefGoogle Scholar
  36. 36.
    Idris NM, Gnansammandhan MK, Zhang J, Ho PC, Mahendran R, Zhang Y (2012) In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nat Med 18:1580–1586CrossRefGoogle Scholar
  37. 37.
    Harjanto D, Lee J, Kim J-M, Jaworski J (2013) Controlling and assessing the surface display of cell-binding domains on magnetite conjugated fluorescent liposomes. Langmuir 29:7949–7956CrossRefGoogle Scholar
  38. 38.
    Won S, Sim SJ (2012) Signal enhancement of a micro-arrayed polydiacetylene (PDA) biosensor using gold nanoparticles. Analyst 137:1241–1246CrossRefGoogle Scholar
  39. 39.
    Hanks TW, Yuan Z (2008) A reversible colorimetric and fluorescent polydiacetylene vesicle sensor platform. Polymer 49:5023–5026CrossRefGoogle Scholar
  40. 40.
    Li X, Kohli P (2010) Investigating molecular interactions in biosensors based on fluorescence resonance energy transfer. J Phys Chem C 114:6255–6264CrossRefGoogle Scholar
  41. 41.
    Leff DV, Ohara PC, Heath JR, Gelbart WM (1995) Thermodynamic control of gold nanocrystal size: experiment and theory. J Phys Chem 99:7036–7041CrossRefGoogle Scholar
  42. 42.
    Wright-Walker CJ, Hansen CE, Evans MA, Nyers ES, Hanks TW (2013) Efficient production of fluorescent polydiacetylene-containing liposomes for pathogen detection and identification. MRS Proc 1569:mrss13–mr1569-qq01–03.  https://doi.org/10.1557/opl2013.1099
  43. 43.
    Park S-H, Oh S-G, Mun J, Han S-S (2006) Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities. Colloids Surf B: Biointerfaces 48:112–118CrossRefGoogle Scholar
  44. 44.
    Gardikis K, Hatziantoniou S, Viras K, Wagner M, Demetzos C (2006) Interaction of dendrimers with model lipid membranes assessed by DSC and RAMAN spectroscopy. In: Mozafari MR (ed) Nanocarrier technologies: Frontiers of Nanotherapy. Springer, Netherlands, pp 207–220CrossRefGoogle Scholar
  45. 45.
    Demetzos C (2008) Differential scanning calorimetry (DSC): a tool to study the thermal behavior of lipid bilayers and liposomal stability. J Liposome Res 18:159–173CrossRefGoogle Scholar
  46. 46.
    Abboud R, Greige-Gerges H, Charcosset C (2015) Effect of progesterone, its hydroxylated and methylated derivatives, and dydrogesterone on lipid bilayer membranes. J Membr Biol 248:811–824CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryFurman UniversityGreenvilleUSA

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