Colloid and Polymer Science

, Volume 297, Issue 1, pp 85–93 | Cite as

Incorporation of gold nanoparticles into the bilayer of polydiacetylene unilamellar vesicles

  • Andrew Tobias
  • William Rooke
  • Timothy W. HanksEmail author
Original Contribution


Gold nanoparticles made with three different alkanethiol surface passivating agents were loaded into the hydrophobic bilayers of polydiacetylene liposomes. The physical and optical properties of the vesicles were compared to each other and a nanoparticle-free control. Small gold nanoparticles were utilized to minimize the plasmon absorption and thereby minimize the effects of energy transfer processes on the optical behavior of the polydiacetylene moiety. The size and structure of the liposomes were examined with dynamic light scattering and electron microscopy, while the stability of the bilayer was investigated through differential scanning calorimetry. Optical spectroscopy was used to monitor the photopolymerization of the vesicles as well as the stress-induced polydiacetylene blue to red transition. Specifically, changes to the absorption frequency, fluorescence frequency, and the fluorescence intensity were monitored. This system can serve as a model system for the optimization of liposomes containing nanoparticles with specialized optical, magnetic, or chemical functionality.


Polydiacetylene Liposome Gold nanoparticle Fluorescence Electron microscopy 



The authors gratefully acknowledge the assistance of Steven Myles, Michelin Americas Research Center, for assistance with TEM data collection.


This work was supported in part by the National Science Foundation EPSCoR Program under NSF Award # OIA-1655740.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect those of the National Science Foundation.

Supplementary material

396_2018_4441_MOESM1_ESM.pdf (1.1 mb)
ESM 1 (PDF 1133 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryFurman UniversityGreenvilleUSA

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