Colloid and Polymer Science

, Volume 296, Issue 9, pp 1509–1514 | Cite as

Synthesis and characterization of ethyl cellulose micro/nanocapsules using solvent evaporation method

  • Sogand AbbaspoorEmail author
  • Ali Ashrafi
  • Mehdi Salehi
Original Contribution


In this study, oil-filled micro/nanocapsules were synthesized by the emulsion-solvent evaporation method using ethyl cellulose as a shell-forming material containing linseed oil. Shape and morphology of the prepared micro/nanocapsules were evaluated using scanning electron microscopy. The particle size distribution of nanocapsules was investigated using nanoparticle size analyzer. The micro/nanocapsules core and shell material were characterized by Fourier transform infrared spectra. Oil-filled micro/nanocapsules with a regular spherical shape were successfully synthesized in various diameters ranging from 33 nm to 400 μm. The size distribution of capsules was successfully controlled by controlling emulsion agitation rate in their synthesis process.


Ethyl cellulose Microcapsule Nanocapsules Solvent evaporation Encapsulation 



This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Bai Y, Jiang C, Wang Q, Wang T (2013) A novel high mechanical strength shape memory polymer based on ethyl cellulose and polycaprolacetone. Carbohydr Polym 96:522–527CrossRefPubMedGoogle Scholar
  2. 2.
    Es-haghi H, Mirabedini SM, Imani M, Farnood RR (2016) Mechanical and self-healing properties of a water-based acrylic latex containing linseed oil filled microcapsules: effect of pre-silanization of microcapsules’ shell compound. Compos Part B 85:305–314CrossRefGoogle Scholar
  3. 3.
    Yang D et al (2014) Green film from renewable resources: properties of epozidized soybean oil plasticized ethyl cellulose films. Carbohydr Polym 103:198–206CrossRefPubMedGoogle Scholar
  4. 4.
    Feczko T, Varga O, Kovacs M, Vidoczy T, Voncina B (2011) Preparation and characterization of photochromic poly (methyl methacrylate) and ethyl cellulose nanocapsules containing a spirooxazine dye. J Photochem Photobiol A Chem 222:293–298CrossRefGoogle Scholar
  5. 5.
    Li X (2015) Preparation and characterization of konjac glucomannan and ethyl cellulose blend films. Food Hydrocoll 44:229–236CrossRefGoogle Scholar
  6. 6.
    Chen J, Wu D, Pan K (2016) Effects of ethyl cellulose on the crystallization and mechanical properties of poly(β-hydroxybutyrate). Int J Biol Macromol 88:120–129CrossRefPubMedGoogle Scholar
  7. 7.
    Quinchia LA, Delgado MA, Reddyhoff T, Gallegos C, Spikes HA (2014) Tribological studies of potential vegetable oil-based lubricants contacting environmentally friendly viscosity modifiers. Tribol Int 69:110–117CrossRefGoogle Scholar
  8. 8.
    Yaoung-Hoon Y, Kab-Young K, Un-Kyu P (2012) Effects of two cellulose binders on the luminous properties of phosphor pastes. Ceram Int 38:1599–1603CrossRefGoogle Scholar
  9. 9.
    Kamel S, Ali N, Jahangir K, Shah SM et al (2008) Pharmaceutical significance of cellulose: a review. Express Polym Lett 2:758–778CrossRefGoogle Scholar
  10. 10.
    Gravelle A, Barbut S, Maragoni A (2013) Fractionation of ethyl cellulose oleogels during setting. Food Funct 4:153–161CrossRefPubMedGoogle Scholar
  11. 11.
    Pan-In P et al (2014) Ethyl cellulose nanoparticles: clarithromycin encapsulation and eradication of H. pylori. Carbohydr Polym 109:22–27CrossRefPubMedGoogle Scholar
  12. 12.
    Hayden D, Kibbelaar H, Imhof A et al (2018) Size and optically tunable ethyl cellulose nanoparticles as carriers for organic UV filters. Chem Nano Mat 44:301–308Google Scholar
  13. 13.
    Murtaza G (2012) Ethyl cellulose microparticles: a review. Acta Pol Pharm Drug Res 69:11–22Google Scholar
  14. 14.
    Sheorey D, Sesha Sai M, Dorle K (1991) A new technique for the encapsulation of water insoluble drugs using ethyl cellulose. J Microencapsul 8:359–368CrossRefPubMedGoogle Scholar
  15. 15.
    Sappidi S, Thadkala K, Kota J, Aukunuru J (2014) Preparation and characterization of ethyl cellulose microspheres encapsulating metformin hydrochloride and glipizide. Pharm Lett 6:213–226Google Scholar
  16. 16.
    Sudhamani T, Noveenkumar K (2010) Preparation and evaluation of ethyl cellulose microspheres of ibuprofen for sustained drug delivery. International Journal of Pharma Research and Development 2:119–125Google Scholar
  17. 17.
    Garekani H, Sanadgol N, Nayyeri N et al (2018) Peculiar effect of polyethylene glycol in comparison with triethyl citrate or diethyl phthalate on properties of ethyl cellulose microcapsules containing propranolol hydrochloride in process of emulsion-solvent evaporation. Drug Dev Ind Pharm 44(3):421–431CrossRefGoogle Scholar
  18. 18.
    Eshaghi H, Mirabedini SM, Imani M, Farnood R (2014) Preparation and characterization of pre-silane modified ethyl cellulose-based microcapsules containing linseed oil. Colloids Surf A Physicochem Eng Asp 447:71–80CrossRefGoogle Scholar
  19. 19.
    Mirabedini SM, Dutil I, Farnood RR (2012) Preparation and characterization of ethyl cellulose-based core–shell microcapsules containing plant oils. Colloids Surf A Physicochem Eng Asp 394:74–84CrossRefGoogle Scholar
  20. 20.
    Feczko T, Varga O, Kovacs M et al (2011) Preparation and characterization of photochromic poly(methyl methacrylate) and ethyl cellulose nanocapsules containing a spirooxazine dye. J Photochem Photobiol A Chem 222:293–298CrossRefGoogle Scholar
  21. 21.
    Voncina B, Kreft O, Kokol V, Chen WT (2009) Encapsulation of rosemary oil in ethyl cellulose microcapsules. Textile and Polymer Journal 1Google Scholar
  22. 22.
    Badulescu R, Vivod V, Jausovec D, Voncina B (2010) Treatment of cotton fabrics with ethyl cellulose microcapsules. Woodhead publishing, pp 226–235Google Scholar
  23. 23.
    Suwannateep N et al (2011) Mucoadhesive curcumin nanospheres: biological activity, adhesion to stomach mucosa and release of curcumin into the circulation. J Control Release 151:176–182CrossRefPubMedGoogle Scholar
  24. 24.
    Pinto C, Neufeld R, Ribeiro A, Veiga F (2006) Nanoencapsulation: methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine 2:8–21CrossRefGoogle Scholar
  25. 25.
    Mirabidini SM, Dutil I, Gauquelin L et al (2015) Preparation of self-healing acrylic latex coatings using novel oil-filled ethyl cellulose microcapsules. Prog Org Coat 85:168–177CrossRefGoogle Scholar
  26. 26.
    Balancua B, Stan R, Hanganu A, Iovu H (2014) Novel linseed oil-based monomers: synthesis and characterization. UPB Scientific Bulletin 76Google Scholar
  27. 27.
    Mahmoudian M, Nozad E, Ghasemi M et al (2018) Preparation and investigation of hybrid self-healing coatings containing linseed oil loaded nanocapsules, potassium ethyl xanthate and benzotriazole on copper surface. Surf Eng 120:167–178Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Materials EngineeringIsfahan University of TechnologyIsfahanIran

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