Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults
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Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese population.
Dietary intake was investigated by a validated 100-item food frequency questionnaire. Daily intakes of quercetin and nutrients were calculated accordingly. T2DM was diagnosed based on the criteria of the American Diabetes Association. Adjusted logistic regression models were used to analyze the relationship between the quartiles of quercetin intake and the prevalence of T2DM.
The prevalences of T2DM were 8.35% in men and 4.68% in women. The main food sources of quercetin were apple, orange, and green tea. Daily intake of quercetin was 20.9 ± 2.32 mg/day (mean ± SD). After adjusting for potentially confounding factors, the odds ratios (95% CI) for T2DM across the ascending quartiles of quercetin intake were: 1.00 (reference), 0.75 (0.60–0.95), 0.76 (0.59–0.99), and 0.63 (0.51–0.94).
The results of the present study showed that quercetin intake was inversely related to the prevalence of T2DM in the Chinese population, suggesting a protective effect of quercetin in the development of T2DM.
KeywordsQuercetin Type 2 diabetes mellitus Chinese population Cross-sectional study
The authors gratefully acknowledge all the people that have made this study. This work was supported financially by grants from the Tianjin Research Program of Application Foundation and Advanced Technology (Project no. 13JCQNJC11800), the National Natural Science Foundation of China (nos. 81673166, 81372118, 81372467 and 81302422), and the key technologies R&D program of Tianjin (Key Project: nos. 11ZCGYSY05700, 12ZCZDSY20400, 13ZCZDSY20200, and 15YFYZSY00020).
ZY, CG and KN contributed to the study conception and design. ZY, YG, QZ, LL, GM, HW, YX, XB, HS, SS, XW, MZ, QJ, YW, KS, WG, CG, and KN contributed to data collection, assembly, analysis and interpretation of the data. ZY, KN and CG contributed to drafting of the manuscript. All authors approved the final version of the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare no competing financial interests.
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