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European Journal of Nutrition

, Volume 58, Issue 2, pp 819–830 | Cite as

Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults

  • Zhanxin Yao
  • Yeqing Gu
  • Qing Zhang
  • Li Liu
  • Ge Meng
  • Hongmei Wu
  • Yang Xia
  • Xue Bao
  • Hongbin Shi
  • Shaomei Sun
  • Xing Wang
  • Ming Zhou
  • Qiyu Jia
  • Yuntang Wu
  • Kun Song
  • Weina Gao
  • Changjiang GuoEmail author
  • Kaijun NiuEmail author
Original Contribution

Abstract

Purpose

Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese population.

Methods

Dietary intake was investigated by a validated 100-item food frequency questionnaire. Daily intakes of quercetin and nutrients were calculated accordingly. T2DM was diagnosed based on the criteria of the American Diabetes Association. Adjusted logistic regression models were used to analyze the relationship between the quartiles of quercetin intake and the prevalence of T2DM.

Results

The prevalences of T2DM were 8.35% in men and 4.68% in women. The main food sources of quercetin were apple, orange, and green tea. Daily intake of quercetin was 20.9 ± 2.32 mg/day (mean ± SD). After adjusting for potentially confounding factors, the odds ratios (95% CI) for T2DM across the ascending quartiles of quercetin intake were: 1.00 (reference), 0.75 (0.60–0.95), 0.76 (0.59–0.99), and 0.63 (0.51–0.94).

Conclusions

The results of the present study showed that quercetin intake was inversely related to the prevalence of T2DM in the Chinese population, suggesting a protective effect of quercetin in the development of T2DM.

Keywords

Quercetin Type 2 diabetes mellitus Chinese population Cross-sectional study 

Notes

Acknowledgements

The authors gratefully acknowledge all the people that have made this study. This work was supported financially by grants from the Tianjin Research Program of Application Foundation and Advanced Technology (Project no. 13JCQNJC11800), the National Natural Science Foundation of China (nos. 81673166, 81372118, 81372467 and 81302422), and the key technologies R&D program of Tianjin (Key Project: nos. 11ZCGYSY05700, 12ZCZDSY20400, 13ZCZDSY20200, and 15YFYZSY00020).

Author contributions

ZY, CG and KN contributed to the study conception and design. ZY, YG, QZ, LL, GM, HW, YX, XB, HS, SS, XW, MZ, QJ, YW, KS, WG, CG, and KN contributed to data collection, assembly, analysis and interpretation of the data. ZY, KN and CG contributed to drafting of the manuscript. All authors approved the final version of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interests.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Zhanxin Yao
    • 1
    • 2
  • Yeqing Gu
    • 2
  • Qing Zhang
    • 3
  • Li Liu
    • 3
  • Ge Meng
    • 2
  • Hongmei Wu
    • 2
  • Yang Xia
    • 2
  • Xue Bao
    • 2
  • Hongbin Shi
    • 3
  • Shaomei Sun
    • 3
  • Xing Wang
    • 3
  • Ming Zhou
    • 3
  • Qiyu Jia
    • 3
  • Yuntang Wu
    • 2
  • Kun Song
    • 3
  • Weina Gao
    • 1
  • Changjiang Guo
    • 1
    Email author
  • Kaijun Niu
    • 2
    Email author
  1. 1.Department of NutritionTianjin Institute of Health and Environmental MedicineTianjinChina
  2. 2.Nutritional Epidemiology Institute and School of Public HealthTianjin Medical UniversityTianjinChina
  3. 3.Health Management CenterTianjin Medical University General HospitalTianjinChina

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