Ablation of premature ventricular contractions in a transplanted human heart suffering from graft vasculopathy

  • Leonard Bergau
  • Mustapha El-Hamriti
  • Philipp Sommer
  • Christian SohnsEmail author
Letter to the Editors


This case report demonstrates that ablation of premature ventricular contractions (PVCs) arising from the papillary muscle can be performed safe and effective in a patient suffering from graft vasculopathy transferring ablation strategies from native hearts. A 66-year-old male patient was referred to our hospital due to frequent PVCs with > 20,000 PVCs in 24-h Holter monitoring (PVC burden 25%). The patient received an orthotopic heart transplant at our center due to dilated cardiomyopathy (DCM) in 1992. Following a relatively long observational period without any serious complications, three-vessel graft vasculopathy with chronic occlusion of the right coronary artery (RCA) was diagnosed in 2008. In 2015, a significant stenosis of the circumflex artery (RCx) was revascularized by percutaneous transluminal coronary angioplasty (PTCA). Afterwards, no progression of the graft vasculopathy was found. Furthermore, myocardial biopsies found no evidence for a progressive graft-vs-host...


Compliance with ethical standard

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Clinic for Electrophysiology, Herz- und Diabeteszentrum Nordrhein-WestfalenRuhr-Universität BochumBad OeynhausenGermany

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