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Geriatrische Onkologie

  • Ulrich WeddingEmail author
CME
  • 43 Downloads

Zusammenfassung

Aufgrund der demografischen Entwicklung mit einer zunehmenden Zahl alter Menschen und des altersabhängigen Anstiegs der Inzidenzrate der Krebserkrankungen wird die Zahl alter Menschen mit Krebserkrankungen in den kommenden Jahrzehnten erheblich ansteigen. In der Geriatrie wurde ein strukturiertes systematisches Assessment etabliert, um Defizite und Ressourcen des einzelnen Patienten zu erkennen und individuelle Therapieplanungen vornehmen zu können. Die Forschung in der geriatrischen Onkologie hat bisher gezeigt, dass die Übertragung des Assessments von der Geriatrie zur Onkologie hilft, unabhängig vom chronologischen Alter, Patienten mit altersabhängigen Einschränkungen besser zu erkennen. Solche Einschränkungen sind zudem prädiktiv für ein höheres Risiko der Therapieunverträglichkeit und für geringeres Überleben. Geriatrisches Assessment hilft dabei, eine onkologische Therapie besser zu stratifizieren und somit Über- und Untertherapie zu vermeiden. In aktuellen Studien wird untersucht, ob auf den Ergebnissen des Assessments aufbauende Interventionen zu einer Verbesserung von für die Patienten relevanten Endpunkten beitragen. Für alte Patienten relevante Endpunkte, wie der Erhalt der Fähigkeit zur Selbstversorgung, sind bisher unzureichend in onkologische Therapiestudien integriert worden.

Schlüsselwörter

Geriatrisches Assessment Vulnerable Populationen Gebrechlichkeit Patientenberichtete Endpunkte Geriatrie 

Geriatric oncology

Abstract

Demographic changes have resulted in an increasing number of old people. Together with the age-dependent increase cancer incidence rates, the number of older people with cancer will increase significantly in the coming decades. In geriatric medicine, a structured systematic assessment has been established to recognize an individual patient’s deficits and resources in order to be able to tailor an individualized treatment plan. Research in geriatric oncology has demonstrated that transfer of the geriatric assessment from geriatric medicine to oncology helps to identify patients with age-dependent deficits, independent of their chronological age. Such impairments are also predictive for a higher risk of treatment-associated side effects and poorer survival. In addition, geriatric assessment helps to stratify older cancer patients for treatment and avoid under- and over-treatment. Current research strategies address the question of whether interventions based on the results of the geriatric assessment can improve outcomes relevant to the patients. In the past, patient-relevant outcomes, such as maintenance of the ability to care for oneself, were poorly integrated in oncological trials.

Keywords

Geriatric assessment Vulnerable populations Frailty Patient-reported outcome measures Geriatrics 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

U. Wedding gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Abteilung für PalliativmedizinUniversitätsklinikum JenaJenaDeutschland

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