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International Journal of Colorectal Disease

, Volume 34, Issue 11, pp 1871–1877 | Cite as

MiR-218 and miR-100 polymorphisms as markers of irinotecan-based chemotherapy response in metastatic colorectal cancer

  • Dimitra-Ioanna Lampropoulou
  • Gerasimos Aravantinos
  • Konstantinos Laschos
  • Theodosis Theodosopoulos
  • Christos Papadimitriou
  • Maria GazouliEmail author
Original Article
  • 57 Downloads

Abstract

Purpose

Colorectal cancer is the fourth cause of cancer-related death. Drug toxicity and resistance remain concerns of major importance. miR-100 and miR-218 are micro-RNAs that regulate cellular proliferation, differentiation and apoptosis acting as oncogenes and tumour suppressors; their functions and have been linked with toxicity development and drug resistance.

Methods

We investigated the correlation between rs11134527 miR-218 and rs1834306 miR-100 polymorphisms and irinotecan-based regimens with regard to drug efficacy and toxicity. A total of 105 mCRC patients receiving irinotecan-based regimens were included in our study and assessed in terms of toxicity development and response to treatment. Rs11134527 miR-218 and rs1834306 miR-100 polymorphism genotyping in the peripheral blood was performed with PCR-RFLP.

Results

Neither rs11134527 miR-218 nor rs1834306 miR-100 are associated with toxicity risk to treatment regimens. GA/AA genotypes of rs11134527 and CT/TT genotypes of rs1834306 were associated with a significantly reduced time-to-progression (TTP) and overall survival (OS).

Conclusions

GA/AA genotypes of rs11134527 miR-218 and CT/TT genotypes of rs1834306 miR-100 polymorphisms could serve as prognostic biomarkers of TTP and OS. Carriers of the A allele of the miR-218 rs11134527 and T allele of the miR-100 rs1834306 polymorphisms are more likely not to respond to irinotecan-based therapies. However, further studies in larger patient populations are required.

Keywords

miRNAs Single-nucleotide polymorphisms mCRC Irinotecan Chemotherapy 

Notes

Funding information

Funding was provided by Hellenic Society of Medical Oncology grant to M. Gazouli and G. Aravantinos.

Compliance with ethical standards

All participants in the study signed an informed consent form. This case–control study is in accordance with the Helsinki Declaration and has been approved by the centres Review Board

Conflict of interest

The authors declare that they have no conflict of interests.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Dimitra-Ioanna Lampropoulou
    • 1
  • Gerasimos Aravantinos
    • 1
  • Konstantinos Laschos
    • 1
  • Theodosis Theodosopoulos
    • 2
  • Christos Papadimitriou
    • 2
  • Maria Gazouli
    • 3
    Email author
  1. 1.Second Department of Medical OncologyGeneral Oncology Hospital of Kifissia “Agioi Anargiroi”AthensGreece
  2. 2.Second Department of Surgery, Aretaieion Hospital, Medical SchoolNational and Kapodistrian University of AthensAthensGreece
  3. 3.Laboratory of Biology, Medical SchoolNational and Kapodistrian University of AthensAthensGreece

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