Time-saving polyp detection in colon capsule endoscopy: evaluation of a novel software algorithm
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Colon capsule endoscopy (CCE) is a reliable method to detect colonic polyps in the well-prepared colon. As CCE evaluation can be time consuming, a new software algorithm might aid in reducing evaluation time.
The aim of the study was to evaluate whether it is feasible to reliably detect colon polyps in CCE videos with a new software algorithm the “collage mode” (Rapid 8 Software, Covidien/Medtronic®).
Twenty-nine CCE videos were randomly presented to three experienced and to three inexperienced investigators. Videos were evaluated by applying the collage mode. Investigation time was documented and the results (≥one polyp vs. no polyp) were compared with the findings of two highly experienced central readers who read the CCE videos in the standard mode beforehand.
It took a median time of 9.8, 3.5, and 7.5 vs. 4.3, 4.6 and 12.5 min for experienced vs. inexperienced investigators to review the CCE videos. For detecting ≥one polyp vs. no polyp, sensitivity of 93.3%, 73.3%, and 93.3% was observed for the experienced and sensitivity of 46.7%, 33.3%, and 93.3% for the inexperienced CCE readers.
Collage mode might allow for a quick review of CCE videos with a high polyp detection rate for experienced CCE readers. Future prospective studies should include CCE collage mode for rapid polyp detection to further prove the feasibility of practical colon polyp detection by CCE and possibly support the role of CCE as a screening tool in CRC prevention.
KeywordsColon capsule endoscopy Polyp Colonoscopy Endoscopy Capsule endoscopy Adenoma
The authors have contributed to the manuscript by planning the study (JH, JPL JA, NF, MK, MF), collecting the data (JH, JPL, JA, JM, AT, MP, MK, MF), analysis and interpretation of data (JH, JA, NF, MF), and preparation (JH, JA, AK) and revision of the manuscript (all authors).
Compliance with ethical standards
Approval for this study was obtained by the local ethics committee of the university hospital Frankfurt prior to the beginning of the study (file number 189/14).
Conflict of interest
Jörg Albert, Michael Farnbacher, Johannes Hausmann, Michael Philipper, and Andrea Tal report lecturer fees from Covidien/Medtronic® all outside of the submitted work.
- 2.Skinner CS, Gupta S, Halm EA, Wright S, McCallister K, Bishop W, Santini N, Mayorga C, Agrawal D, Moran B, Sanders JM, Singal AG (2016) Development of the Parkland-UT Southwestern Colonoscopy Reporting System (CoRS) for evidence-based colon cancer surveillance recommendations. J Am Med Inform Assoc 23(2):402–406CrossRefGoogle Scholar
- 3.Kerrison RS, McGregor LM, Marshall S, Isitt J, Counsell N et al (2017) Improving uptake of flexible sigmoidoscopy screening: a randomized trial of nonparticipant reminders in the English Screening Programme. Endoscopy 49(1):35–43Google Scholar
- 9.Spada C, Hassan C, Munoz-Navas M, Neuhaus H, Deviere J, Fockens P, Coron E, Gay G, Toth E, Riccioni ME, Carretero C, Charton JP, van Gossum A, Wientjes CA, Sacher-Huvelin S, Delvaux M, Nemeth A, Petruzziello L, de Frias CP, Mayershofer R, Aminejab L, Dekker E, Galmiche JP, Frederic M, Johansson GW, Cesaro P, Costamagna G (2011) Second-generation colon capsule endoscopy compared with colonoscopy. Gastrointest Endosc 74(3):581–589.e1CrossRefGoogle Scholar
- 12.Shiotani A, Honda K, Kawakami M, Kimura Y, Yamanaka Y, Fujita M, Matsumoto H, Tarumi KI, Manabe N, Haruma K (2012) Analysis of small-bowel capsule endoscopy reading by using Quickview mode: training assistants for reading may produce a high diagnostic yield and save time for physicians. J Clin Gastroenterol 46(10):e92–e95CrossRefGoogle Scholar
- 19.Saito Y, Saito S, Oka S, Kakugawa Y, Matsumoto M, Aihara H, Watari I, Aoyama T, Nouda S, Kuramoto T, Watanabe K, Ohmiya N, Higuchi K, Goto H, Arakawa T, Tanaka S, Tajiri H (2015) Evaluation of the clinical efficacy of colon capsule endoscopy in the detection of lesions of the colon: prospective, multicenter, open study. Gastrointest Endosc 82(5):861–869CrossRefGoogle Scholar
- 20.Alvarez-Urturi C, Fernandez-Esparrach G, Ibanez IA, Rodriguez De Miguel C, Dedeu JM et al (2017) Accuracy of colon capsule endoscopy in detecting colorectal polyps in individuals with familial colorectal cancer: could we avoid colonoscopies. Gastroenterol Res Pract 2017:1507914CrossRefGoogle Scholar
- 21.Otani I, Oka S, Tanaka S, Iio S, Tsuboi A, Kunihara S, Hiyama Y, Chayama K (2019) Diagnostic yield of colon capsule endoscopy in detection of superficial colorectal lesions. Digestion:1–8Google Scholar
- 25.Spada C, Hassan C, Barbaro B, Iafrate F, Cesaro P, Petruzziello L, Minelli Grazioli L, Senore C, Brizi G, Costamagna I, Alvaro G, Iannitti M, Salsano M, Ciolina M, Laghi A, Bonomo L, Costamagna G (2015) Colon capsule versus CT colonography in patients with incomplete colonoscopy. A prospective, comparative trial. Gut 64(2):272–281CrossRefGoogle Scholar
- 26.Rondonotti E, Borghi C, Mandelli G, Radaelli F, Paggi S, Amato A, Imperiali G, Terreni N, Lenoci N, Terruzzi V, Baccarin A, Martegani A, Spinzi G (2014) Accuracy of capsule colonoscopy and computed tomographic colonography in individuals with positive results from the fecal occult blood test. Clin Gastroenterol Hepatol 12(8):1303–1310CrossRefGoogle Scholar