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Time-saving polyp detection in colon capsule endoscopy: evaluation of a novel software algorithm

  • Johannes HausmannEmail author
  • Jan-Peter Linke
  • Jörg G. Albert
  • Johannes Masseli
  • Andrea Tal
  • Alica Kubesch
  • Natalie Filmann
  • Michael Philipper
  • Michael Farnbacher
Original Article
  • 31 Downloads

Abstract

Background

Colon capsule endoscopy (CCE) is a reliable method to detect colonic polyps in the well-prepared colon. As CCE evaluation can be time consuming, a new software algorithm might aid in reducing evaluation time.

Objectives

The aim of the study was to evaluate whether it is feasible to reliably detect colon polyps in CCE videos with a new software algorithm the “collage mode” (Rapid 8 Software, Covidien/Medtronic®).

Methods

Twenty-nine CCE videos were randomly presented to three experienced and to three inexperienced investigators. Videos were evaluated by applying the collage mode. Investigation time was documented and the results (≥one polyp vs. no polyp) were compared with the findings of two highly experienced central readers who read the CCE videos in the standard mode beforehand.

Results

It took a median time of 9.8, 3.5, and 7.5 vs. 4.3, 4.6 and 12.5 min for experienced vs. inexperienced investigators to review the CCE videos. For detecting ≥one polyp vs. no polyp, sensitivity of 93.3%, 73.3%, and 93.3% was observed for the experienced and sensitivity of 46.7%, 33.3%, and 93.3% for the inexperienced CCE readers.

Conclusion

Collage mode might allow for a quick review of CCE videos with a high polyp detection rate for experienced CCE readers. Future prospective studies should include CCE collage mode for rapid polyp detection to further prove the feasibility of practical colon polyp detection by CCE and possibly support the role of CCE as a screening tool in CRC prevention.

Keywords

Colon capsule endoscopy Polyp Colonoscopy Endoscopy Capsule endoscopy Adenoma 

Notes

Author contributions

The authors have contributed to the manuscript by planning the study (JH, JPL JA, NF, MK, MF), collecting the data (JH, JPL, JA, JM, AT, MP, MK, MF), analysis and interpretation of data (JH, JA, NF, MF), and preparation (JH, JA, AK) and revision of the manuscript (all authors).

Compliance with ethical standards

Approval for this study was obtained by the local ethics committee of the university hospital Frankfurt prior to the beginning of the study (file number 189/14).

Conflict of interest

Jörg Albert, Michael Farnbacher, Johannes Hausmann, Michael Philipper, and Andrea Tal report lecturer fees from Covidien/Medtronic® all outside of the submitted work.

References

  1. 1.
    Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386CrossRefGoogle Scholar
  2. 2.
    Skinner CS, Gupta S, Halm EA, Wright S, McCallister K, Bishop W, Santini N, Mayorga C, Agrawal D, Moran B, Sanders JM, Singal AG (2016) Development of the Parkland-UT Southwestern Colonoscopy Reporting System (CoRS) for evidence-based colon cancer surveillance recommendations. J Am Med Inform Assoc 23(2):402–406CrossRefGoogle Scholar
  3. 3.
    Kerrison RS, McGregor LM, Marshall S, Isitt J, Counsell N et al (2017) Improving uptake of flexible sigmoidoscopy screening: a randomized trial of nonparticipant reminders in the English Screening Programme. Endoscopy 49(1):35–43Google Scholar
  4. 4.
    Lee YJ, Kim ES, Choi JH, Lee KI, Park KS et al (2015) Impact of reinforced education by telephone and short message service on the quality of bowel preparation: a randomized controlled study. Endoscopy 47(11):1018–1027CrossRefGoogle Scholar
  5. 5.
    Greenspan M, Chehl N, Shawron K, Barnes L, Li H, Avery E, Sims S, Losurdo J, Mobarhan S, Melson J (2015) Patient non-adherence and cancellations are higher for screening colonoscopy compared with surveillance colonoscopy. Dig Dis Sci 60(10):2930–2936CrossRefGoogle Scholar
  6. 6.
    Partin MR, Gravely A, Gellad ZF, Nugent S, Burgess JF Jr et al (2016) Factors associated with missed and cancelled colonoscopy appointments at veterans health administration facilities. Clin Gastroenterol Hepatol 14(2):259–267CrossRefGoogle Scholar
  7. 7.
    Shafer LA, Walker JR, Waldman C, Yang C, Michaud V, Bernstein CN, Hathout L, Park J, Sisler J, Restall G, Wittmeier K, Singh H (2018) Factors associated with anxiety about colonoscopy: the preparation, the procedure, and the anticipated findings. Dig Dis Sci 63(3):610–618CrossRefGoogle Scholar
  8. 8.
    Rex DK, Adler SN, Aisenberg J, Burch WC Jr, Carretero C et al (2015) Accuracy of capsule colonoscopy in detecting colorectal polyps in a screening population. Gastroenterology 148(5):948–957.e2CrossRefGoogle Scholar
  9. 9.
    Spada C, Hassan C, Munoz-Navas M, Neuhaus H, Deviere J, Fockens P, Coron E, Gay G, Toth E, Riccioni ME, Carretero C, Charton JP, van Gossum A, Wientjes CA, Sacher-Huvelin S, Delvaux M, Nemeth A, Petruzziello L, de Frias CP, Mayershofer R, Aminejab L, Dekker E, Galmiche JP, Frederic M, Johansson GW, Cesaro P, Costamagna G (2011) Second-generation colon capsule endoscopy compared with colonoscopy. Gastrointest Endosc 74(3):581–589.e1CrossRefGoogle Scholar
  10. 10.
    Spada C, Hassan C, Galmiche JP, Neuhaus H, Dumonceau JM et al (2012) Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 44(5):527–536CrossRefGoogle Scholar
  11. 11.
    Farnbacher MJ, Krause HH, Hagel AF, Raithel M, Neurath MF, Schneider T (2014) QuickView video preview software of colon capsule endoscopy: reliability in presenting colorectal polyps as compared to normal mode reading. Scand J Gastroenterol 49(3):339–346CrossRefGoogle Scholar
  12. 12.
    Shiotani A, Honda K, Kawakami M, Kimura Y, Yamanaka Y, Fujita M, Matsumoto H, Tarumi KI, Manabe N, Haruma K (2012) Analysis of small-bowel capsule endoscopy reading by using Quickview mode: training assistants for reading may produce a high diagnostic yield and save time for physicians. J Clin Gastroenterol 46(10):e92–e95CrossRefGoogle Scholar
  13. 13.
    Brechmann T, Schmiegel W, Klute L, Rosch T, Pox C (2016) Feasibility of a colon capsule overnight procedure followed by colonoscopy. Z Gastroenterol 54(2):146–151CrossRefGoogle Scholar
  14. 14.
    Leighton JA, Rex DK (2011) A grading scale to evaluate colon cleansing for the PillCam COLON capsule: a reliability study. Endoscopy 43(2):123–127CrossRefGoogle Scholar
  15. 15.
    Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159–174CrossRefGoogle Scholar
  16. 16.
    Jemal A, Clegg LX, Ward E, Ries LAG, Wu X, Jamison PM, Wingo PA, Howe HL, Anderson RN, Edwards BK (2004) Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer 101(1):3–27CrossRefGoogle Scholar
  17. 17.
    Kobaek-Larsen M, Kroijer R, Dyrvig A-K, Buijs MM, Steele RJC, Qvist N, Baatrup G (2018) Back-to-back colon capsule endoscopy and optical colonoscopy in colorectal cancer screening individuals. Color Dis 20(6):479–485CrossRefGoogle Scholar
  18. 18.
    Pioche M, Ganne C, Gincul R, de LA, Marsot J et al (2018) Colon capsule versus computed tomography colonography for colorectal cancer screening in patients with positive fecal occult blood test who refuse colonoscopy: a randomized trial. Endoscopy 50(8):761–769CrossRefGoogle Scholar
  19. 19.
    Saito Y, Saito S, Oka S, Kakugawa Y, Matsumoto M, Aihara H, Watari I, Aoyama T, Nouda S, Kuramoto T, Watanabe K, Ohmiya N, Higuchi K, Goto H, Arakawa T, Tanaka S, Tajiri H (2015) Evaluation of the clinical efficacy of colon capsule endoscopy in the detection of lesions of the colon: prospective, multicenter, open study. Gastrointest Endosc 82(5):861–869CrossRefGoogle Scholar
  20. 20.
    Alvarez-Urturi C, Fernandez-Esparrach G, Ibanez IA, Rodriguez De Miguel C, Dedeu JM et al (2017) Accuracy of colon capsule endoscopy in detecting colorectal polyps in individuals with familial colorectal cancer: could we avoid colonoscopies. Gastroenterol Res Pract 2017:1507914CrossRefGoogle Scholar
  21. 21.
    Otani I, Oka S, Tanaka S, Iio S, Tsuboi A, Kunihara S, Hiyama Y, Chayama K (2019) Diagnostic yield of colon capsule endoscopy in detection of superficial colorectal lesions. Digestion:1–8Google Scholar
  22. 22.
    Alarcon-Fernandez O, Ramos L, Adrian-de-Ganzo Z, Gimeno-Garcia AZ, Nicolas-Perez D et al (2013) Effects of colon capsule endoscopy on medical decision making in patients with incomplete colonoscopies. Clin Gastroenterol Hepatol 11(5):534–40.e1CrossRefGoogle Scholar
  23. 23.
    Triantafyllou K, Viazis N, Tsibouris P, Zacharakis G, Kalantzis C, Karamanolis DG, Ladas SD (2014) Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice. Gastrointest Endosc 79(2):307–316CrossRefGoogle Scholar
  24. 24.
    Baltes P, Bota M, Albert J, Philipper M, Horster H-G et al (2018) PillCamColon2 after incomplete colonoscopy - a prospective multicenter study. World J Gastroenterol 24(31):3556–3566CrossRefGoogle Scholar
  25. 25.
    Spada C, Hassan C, Barbaro B, Iafrate F, Cesaro P, Petruzziello L, Minelli Grazioli L, Senore C, Brizi G, Costamagna I, Alvaro G, Iannitti M, Salsano M, Ciolina M, Laghi A, Bonomo L, Costamagna G (2015) Colon capsule versus CT colonography in patients with incomplete colonoscopy. A prospective, comparative trial. Gut 64(2):272–281CrossRefGoogle Scholar
  26. 26.
    Rondonotti E, Borghi C, Mandelli G, Radaelli F, Paggi S, Amato A, Imperiali G, Terreni N, Lenoci N, Terruzzi V, Baccarin A, Martegani A, Spinzi G (2014) Accuracy of capsule colonoscopy and computed tomographic colonography in individuals with positive results from the fecal occult blood test. Clin Gastroenterol Hepatol 12(8):1303–1310CrossRefGoogle Scholar
  27. 27.
    Eliakim R, Yassin K, Niv Y, Metzger Y, Lachter J, Gal E, Sapoznikov B, Konikoff F, Leichtmann G, Fireman Z, Kopelman Y, Adler S (2009) Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy. Endoscopy 41(12):1026–1031CrossRefGoogle Scholar
  28. 28.
    Tal AO, Vermehren J, Albert JG (2014) Colon capsule endoscopy: current status and future directions. World J Gastroenterol 20(44):16596–16602CrossRefGoogle Scholar
  29. 29.
    Buijs MM, Kroijer R, Kobaek-Larsen M, Spada C, Fernandez-Urien I, Steele RJC, Baatrup G (2018) Intra and inter-observer agreement on polyp detection in colon capsule endoscopy evaluations. United European Gastroenterol J 6(10):1563–1568CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Johannes Hausmann
    • 1
    Email author
  • Jan-Peter Linke
    • 1
    • 2
  • Jörg G. Albert
    • 1
    • 3
  • Johannes Masseli
    • 1
  • Andrea Tal
    • 1
  • Alica Kubesch
    • 1
  • Natalie Filmann
    • 4
  • Michael Philipper
    • 5
  • Michael Farnbacher
    • 6
  1. 1.Department of Internal Medicine 1University Hospital FrankfurtFrankfurtGermany
  2. 2.Department of Internal MedicineHeilig-Geist-HospitalBingenGermany
  3. 3.Department of Internal Medicine, Robert-Bosch-HospitalStuttgartGermany
  4. 4.Institute of Biostatistics and Mathematical ModelingGoethe UniversityFrankfurtGermany
  5. 5.Gastroenterologische FacharztpraxisDüsseldorfGermany
  6. 6.Department of Internal Medicine 2Klinikum FürthFürthGermany

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