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Resting vector volume measured before ileostomy reversal may be a predictor of major fecal incontinence in patients with mid or low rectal cancer: a longitudinal cohort study using a prospective clinical database

  • Min Hyun Kim
  • Myong Hun Ihn
  • Jung Rae Cho
  • Myung Jo Kim
  • Sung Il Kang
  • Heung-Kwon Oh
  • Duck-Woo Kim
  • Sung-Bum KangEmail author
Original Article
  • 16 Downloads

Abstract

Purpose

Despite a high incidence of fecal incontinence following sphincter-preservation surgery (SPS), there are no definitive factors measured before ileostomy reversal that predict fecal incontinence. We investigated whether vector volume anorectal manometry before ileostomy reversal predicts major fecal incontinence following SPS in patients with mid or low rectal cancer.

Methods

This longitudinal prospective cohort study comprised 173 patients who underwent vector volume anorectal manometry before ileostomy reversal. The Fecal Incontinence Severity Index was measured 1 year after the primary SPS and classified as major incontinence (FISI score ≥ 25) or continent/minor incontinence (FISI score < 25). Multivariable logistic regression analysis was used to identify predictors of major incontinence.

Results

Ninety-two patients (53.1%) had major incontinence. Although tumor stage, location, and neoadjuvant chemoradiotherapy were comparable, the major incontinence group had lower resting pressure (28.4 vs. 34.3 mmHg, P = 0.027), greater asymmetry at rest (39.1% vs. 34.1%, P = 0.002) and squeezing (34.2% vs. 31.4%, P = 0.046), shorter sphincter length (3.3 vs. 3.7 cm, P = 0.034), and lower resting vector volume (143,601 vs. 278,922 mmHg2 mm, P < 0.001) compared with the continent/minor incontinence group. Resting vector volume was the only independent predictor of major incontinence (odds ratio = 0.675 per 100,000 mmHg2 mm, 95% confidence interval, 0.532–0.823; P = 0.006).

Conclusions

This study revealed that resting vector volume before ileostomy reversal may predict major fecal incontinence. We suggest that the physiology of the anorectum should be discussed with patients before ileostomy reversal in patients at high risk of fecal incontinence.

Keywords

Anorectal manometry Ileostomy reversal Fecal incontinence 

Notes

Compliance with ethical standards

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

384_2019_3293_MOESM1_ESM.pdf (219 kb)
ESM 1 (PDF 219 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Min Hyun Kim
    • 1
  • Myong Hun Ihn
    • 2
  • Jung Rae Cho
    • 1
  • Myung Jo Kim
    • 1
  • Sung Il Kang
    • 1
  • Heung-Kwon Oh
    • 1
  • Duck-Woo Kim
    • 1
  • Sung-Bum Kang
    • 1
    Email author
  1. 1.Department of SurgerySeoul National University Bundang HospitalSeongnam-siSouth Korea
  2. 2.Department of SurgerySoonchunhyang University Gumi HospitalGumiSouth Korea

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