Does enhanced recovery improve the survival rates of patients 3 years after undergoing surgery to remove a tumor in the colon?

  • P. Viannay
  • A. Hamy
  • R. Jaouen
  • F. X. Caroli-Bosc
  • C. Luel
  • S. Vasseur
  • M. Levaillant
  • J. F. Hamel
  • Aurélien VenaraEmail author
Original Article



The advantages of enhanced recovery programs (ERP) after colorectal surgery for morbidity and length of stay are well known. On a longer term, evidence is much more limited. The aim of this study is to determine the impact of ERP on survival after 3 years of follow-up, following colorectal cancer surgery.


All the patients undergoing resection for colorectal cancer between the years 2010 and 2014 were included. Patients were classified according to their compliance with the ERP (< 70 or ≥ 70%).


Among the 206 patients included during the period, 129 were male (62.6%). The 3-year overall survival rate was 70.4% (145 patients) and relapse-free survival was 59.2% (122 patients). The survival after 3 years was influenced by the initial metastatic status (p < 0.0001), operative morbidity (p < 0.001), and the presence of peritumoral emboli (p = 0.006). However, the compliance with the ERP ≥ 70% did not influence overall survival (p = 0.63), nor relapse-free survival (p = 0.93). The same observations were found among the “at-risk” population (synchronous metastasis and postoperative complication).


The ERP does not seem to influence the 3-year relapse-free survival after colorectal resection for cancer.


Enhanced recovery Colorectal cancer Global survival Disease-free survival 


Author’s contribution

A Venara and P Viannay made substantial contributions to the conception and design of this work, acquisition and interpretation of data and drafted the manuscript. They gave their final approval of the version to be published and their agreement to be held accountable for all aspects of the work.

A Hamy, R Jaouen, C Luel, FX Caroli-Bosc, and S Vasseur made substantial contributions to the acquisition and interpretation of data and critically revised the manuscript, as well as giving their final approval of the version to be published and their agreement to be held accountable for all aspects of the work.

M Levaillant and JF Hamel made substantial contributions to the interpretation and analysis of data and drafted the manuscript, as well as giving his final approval of the version to be published and his agreement to be held accountable for all aspects of the work.

Compliance with ethical standards

Conflict of interest

P Viannay, A Hamy, R Jaouen, FX Caroli-Bosc, C Luel, S Vasseur, M Levaillant, JF Hamel, and A Venara have no conflicts of interest or financial ties related to this work to disclose.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • P. Viannay
    • 1
    • 2
  • A. Hamy
    • 1
    • 2
    • 3
  • R. Jaouen
    • 1
    • 2
  • F. X. Caroli-Bosc
    • 2
    • 3
    • 4
  • C. Luel
    • 2
  • S. Vasseur
    • 2
  • M. Levaillant
    • 5
  • J. F. Hamel
    • 2
    • 5
  • Aurélien Venara
    • 1
    • 2
    • 3
    • 6
    Email author
  1. 1.Department of Visceral and Endocrinal SurgeryCHU AngersAngers Cedex 9France
  2. 2.Département de MédecineUFR Santé d’AngersAngersFrance
  3. 3.EA HIFIHAngersFrance
  4. 4.Department of Digestive and Liver DiseaseCHU AngersAngers Cedex 9France
  5. 5.Department of BiostatisticsCHU AngersAngers Cedex 9France
  6. 6.UMR INSERM 1235, TENSUniversité de NantesNantesFrance

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